Welcome to the official database of the IUPHAR
Committee on Receptor Nomenclature and Drug Classification.
Detailed, peer-reviewed pharmacological, functional and pathophysiological information on human, mouse and rat G Protein-Coupled Receptors, Voltage- and Ligand-Gated Ion Channels, Nuclear Hormone Receptors and selected Enzymes, including all Protein Kinases.
* Orphans are defined as proteins having similarity to receptors but whose endogenous ligands have not yet been conclusively identified.
[Cite the database] [About]
New kinase database under development
NC-IUPHAR Annual Report 2012-13
- NC-IUPHAR is expanding the enzyme section of the database to include all the human protein kinases and selected lipid kinases. The first version of the database contains the genomic and structural information, as well as data from a DiscoveRx KINOMEscan® screening assay of 72 approved and experimental drug inhibitors. Future versions will contain annotation of clinically relevant drugs and kinases, additional screening data, tools to visualise and explore the inhibitor activities across the kinome, and more.
- The latest NC-IUPHAR Annual Report is available to download as a PDF here.
Recent database updates (April 2013) include:
- Full annotation is now available for the P2X1 and P2X2 subunits.
- Family lists have been reorganised into sections on receptors, ion channels and enzymes, with the families arranged in an expandable "tree" format. Some targets may appear in more than one section of the database; for example, Receptor Tyrosine Kinases are listed as both enzymes and receptors.
- Target pages now link to PhosphoSitePlus® (comprehensive information and tools for the study of protein post-translational modifications), HPRD (Human Protein Reference Database: curated information on domain architecture, post-translational modifications, interaction networks and disease association) and GUDMAP (GenitoUrinary Development Molecular Anatomy Project: a molecular atlas of gene expression for the developing organs of the GenitoUrinary (GU) tract).
Stay up to date:
Recent Twitter activity:
Recent Facebook activity:
We welcome all questions, comments and suggestions - Email us: firstname.lastname@example.org
© IUPHAR 2013
These pages are best viewed with Firefox
Page last updated 1st Apr 2013
Contact us | Print | Back to top | Help