IUPHAR DATABASE OF RECEPTORS AND ION CHANNELS

Welcome to the official database of the IUPHAR Committee on Receptor Nomenclature and Drug Classification.

Detailed, peer-reviewed pharmacological, functional and pathophysiological information on human, mouse and rat G Protein-Coupled Receptors, Voltage- and Ligand-Gated Ion Channels, Nuclear Hormone Receptors and selected Enzymes, including all Protein Kinases.

Database content:

There should be some charts here, you may need to enable JavaScript!

* Orphans are defined as proteins having similarity to receptors but whose endogenous ligands have not yet been conclusively identified.

[Cite the database] [About]

Please give us your feedback! Take our quick survey.

Latest news:

New kinase database under development
- NC-IUPHAR is expanding the enzyme section of the database to include all the human protein kinases and selected lipid kinases. The first version of the database contains the genomic and structural information, as well as data from a DiscoveRx KINOMEscan^® screening assay of 72 approved and experimental drug inhibitors. Future versions will contain annotation of clinically relevant drugs and kinases, additional screening data, tools to visualise and explore the inhibitor activities across the kinome, and more.
NC-IUPHAR Annual Report 2012-13
- The latest NC-IUPHAR Annual Report is available to download as a PDF here.

Recent database updates (April 2013) include:

GPCR updates:
- Complement peptide receptor pages and introduction, Hydroxycarboxylic acid receptor pages and introduction, Neuromedin U receptor pages and introduction, Parathyroid hormone receptor pages, Neuropeptide S receptor page and introduction, Tachykinin receptor pages and introduction, Thyrotropin-releasing hormone receptor pages and introduction, and the Somatostatin receptor 2 (sst₂ receptor) page.
LGIC updates:
- Full annotation is now available for the P2X1 and P2X2 subunits.
Other features:
- Family lists have been reorganised into sections on receptors, ion channels and enzymes, with the families arranged in an expandable "tree" format. Some targets may appear in more than one section of the database; for example, Receptor Tyrosine Kinases are listed as both enzymes and receptors.
- Target pages now link to PhosphoSitePlus^® (comprehensive information and tools for the study of protein post-translational modifications), HPRD (Human Protein Reference Database: curated information on domain architecture, post-translational modifications, interaction networks and disease association) and GUDMAP (GenitoUrinary Development Molecular Anatomy Project: a molecular atlas of gene expression for the developing organs of the GenitoUrinary (GU) tract).

Stay up to date:

@IUPHARDB

Like us on Facebook

Subscribe to our mailing list

IUPHAR Database of Receptors and Ion Channels

Useful links:

	BPS/IUPHAR Guide To PHARMACOLOGY - A FREE online portal to quantitative information on drug targets and the prescription medicines and experimental drugs that act on them from the BJP Guide to Receptors and Channels (GRAC) and IUPHAR-DB.
	genenames.org - A curated repository of HGNC-approved gene nomenclature
	Publisher of NC-IUPHAR nomenclature reports and reviews
	Publisher of NC-IUPHAR reviews and featured articles

Recent Twitter activity:

Recent Facebook activity:

Sorry, this content is unavailable until you click to accept cookies from this site.

We welcome all questions, comments and suggestions - Email us: curators@iuphar-db.org

These pages are best viewed with Firefox

Page last updated 1st Apr 2013