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GPR25

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Tissue Distribution
Expression Datasets
Biologically Significant Variants
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 361 1q32.1 GPR25 G protein-coupled receptor 25 1
Mouse 7 367 1 E4 Gpr25 G protein-coupled receptor 25
Rat 7 345 13q13 Gpr25 G protein-coupled receptor 25
Previous and Unofficial Names
GPR25
G-protein coupled receptor 25
probable G-protein coupled receptor 25
Gpr25_predicted
LOC363993
G protein-coupled receptor 25
G protein-coupled receptor 25 (predicted)
LOC383563
Gm1300
Database Links
Ensembl ENSG00000170128 (Hs), ENSMUSG00000052759 (Mm), ENSRNOG00000008603 (Rn)
Entrez Gene 2848 (Hs), 383563 (Mm), 363993 (Rn)
GeneCards GPR25 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr25 (Mm)
HomoloGene 3872 (Hs)
Human Protein Reference Database 03707 (Hs)
InterPro O00155 (Hs), P0C5I1 (Mm)
KEGG Gene hsa:2848 (Hs), mmu:383563 (Mm), rno:363993 (Rn)
OMIM 602174 (Hs)
PharmGKB Gene PA28868 (Hs)
PhosphoSitePlus O00155 (Hs), P0C5I1 (Mm)
Protein Ontology (PRO) PRO:000001524 (Hs)
RefSeq Nucleotide NM_005298 (Hs), NM_001101516 (Mm)
RefSeq Protein NP_005289 (Hs), NP_001094986 (Mm)
TreeFam ENSG00000170128 (Hs), ENSMUSG00000052759 (Mm), ENSRNOG00000008603 (Rn)
UniGene Hs. 534316 (Hs)
UniProt O00155 (Hs), P0C5I1 (Mm)
Wikipedia GPR25
Orphan and other 7TM receptors
Tissue Distribution Comments
Northern blot analysis of poly(A)+ mRNA extracted from human tissues revealed no expression of GPR25 in liver and brain regions examined (basal forebrain, frontal cortex, thalamus, hypothalamus, amygdala, caudate, putamen, hippocampus, midbrain, medulla, cerebellum and pituitary) [1].
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
S360C, low frequency (<10% in all tested populations)
SNP accession:  rs200080169 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
Available Assays
DiscoveRx PathHunter® CHO-K1 GPR25 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0368C2A
DiscoveRx PathHunter® eXpress GPR25 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0368E2ACP2

REFERENCES

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1. Jung, BP; Nguyen, T; Kolakowski, LF; Lynch, KR; Heng, HH; George, SR; O'Dowd, BF. (1997) Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1. Biochem. Biophys. Res. Commun., 230 (1): 69-72. [PMID:9020062]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: GPR25. Last modified on 02/11/2012. Accessed on 22/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=95.


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