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GPR22

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Transduction Mechanisms
Tissue Distribution
Expression Datasets
Physiological Functions
Physiological Consequences of Altering Gene Expression
Phenotypes, Alleles and Disease Models
Clinically-Relevant Mutations and Pathophysiology
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 433 7q22-q31.1 GPR22 G protein-coupled receptor 22 5
Mouse 7 432 12 A3 Gpr22 G protein-coupled receptor 22
Rat 7 - 6q16 Gpr22 G protein-coupled receptor 22
Previous and Unofficial Names
Gpr22_predicted
LOC298944
G protein-coupled receptor 22
G protein-coupled receptor 22 (predicted)
probable G-protein coupled receptor 22
2900068K05Rik
AW061316
Database Links
Ensembl ENSG00000172209 (Hs), ENSMUSG00000044067 (Mm), ENSRNOG00000008423 (Rn)
Entrez Gene 2845 (Hs), 73010 (Mm), 298944 (Rn)
GeneCards GPR22 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr22 (Mm)
HomoloGene 18420 (Hs)
Human Protein Reference Database 03552 (Hs)
InterPro Q99680 (Hs), Q8BZL4 (Mm), D4A3U0 (Rn)
KEGG Gene hsa:2845 (Hs), mmu:73010 (Mm), rno:298944 (Rn)
OMIM 601910 (Hs)
PharmGKB Gene PA28865 (Hs)
PhosphoSitePlus Q99680 (Hs), Q8BZL4 (Mm)
Protein Ontology (PRO) PRO:000001523 (Hs)
RefSeq Nucleotide NM_005295 (Hs), NM_175191 (Mm), NM_001106722 (Rn)
RefSeq Protein NP_005286 (Hs), NP_780400 (Mm), NP_001100192 (Rn)
TreeFam ENSG00000172209 (Hs), ENSMUSG00000044067 (Mm), ENSRNOG00000008423 (Rn)
UniGene Hs. 657277 (Hs)
UniProt Q99680 (Hs), Q8BZL4 (Mm), D4A3U0 (Rn)
Wikipedia GPR22
Orphan and other 7TM receptors
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Adenylate cyclase inhibition
References:  1
Tissue Distribution
Frontal cortex, caudate, putamen, thalamus
Species:  Human
Technique:  Northern blot
References:  5
Brain (cerebellum, cerebral cortex, amygdala), heart
Species:  Human
Technique:  Microarray analysis, Affymetrix GeneChip platform
References:  4
Brain (accumbens, amygdala, cerebellum, cortex, hippocampus), heart (myocardial enrichment)
Species:  Human
Technique:  Northern blot, RT-PCR
References:  1
Brain, heart
Species:  Mouse
Technique:  Northern blot, In situ hybridisation
References:  1
Articular cartilidge of knee
Species:  Mouse
Technique:  Immunohistochemistry
References:  3
Brain, heart (cardiomyocytes, coronory arteries)
Species:  Rat
Technique:  Northern blot, Immunohistochemistry
References:  1
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Functions Comments
Myocardial mRNA expression reduced following aortic banding suggesting a protective role in the hemodynamic stress response associated with increased afterload [1].
Physiological Consequences of Altering Gene Expression
Increased succeptibility to functional decompensation following aortic banding
Species:  Mouse
Tissue:  Heart
Technique:  Gene knockout
References:  1
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr22tm1.1Jwad Gpr22tm1.1Jwad/Gpr22tm1.1Jwad
involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL		 MGI:1920260  MP:0004485 increased response of heart to induced stress PMID: 18539757 
Gpr22tm1Jwad Gpr22tm1Jwad/Gpr22tm1Jwad
involves: 129/Sv * C57BL/6 * SJL		 MGI:1920260  MP:0002169 no abnormal phenotype detected PMID: 18539757 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Osteoarthritis
Role:  Genomewide association studies (GWAS) has linked a locus on chromosome 7q22, including GPR22,/i>, with osteoarthritis. GPR22 positive chodrocyte-like cells have been found in osteophytes in instability-induced osteoarthritis.
References:  2-3,6
Mutations not determined

REFERENCES

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1. Adams, JW; Wang, J; Davis, JR; Liaw, C; Gaidarov, I; Gatlin, J; Dalton, ND; Gu, Y; Ross, J; Behan, D; Chien, K; Connolly, D. (2008) Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Am. J. Physiol. Heart Circ. Physiol., 295 (2): H509-21. [PMID:18539757]

2. Evangelou, E; Valdes, AM; Kerkhof, HJ; Styrkarsdottir, U; Zhu, Y; Meulenbelt, I; Lories, RJ; Karassa, FB; Tylzanowski, P; Bos, SD; et al.. (2011) Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann. Rheum. Dis., 70 (2): 349-55. [PMID:21068099]

3. Kerkhof, HJ; Lories, RJ; Meulenbelt, I; Jonsdottir, I; Valdes, AM; Arp, P; Ingvarsson, T; Jhamai, M; Jonsson, H; Stolk, L; Thorleifsson, G; Zhai, G; Zhang, F; Zhu, Y; van der Breggen, R; Carr, A; Doherty, M; Doherty, S; Felson, DT; Gonzalez, A; Halldorsson, BV; Hart, DJ; Hauksson, VB; Hofman, A; Ioannidis, JP; Kloppenburg, M; Lane, NE; Loughlin, J; Luyten, FP; Nevitt, MC; Parimi, N; Pols, HA; Rivadeneira, F; Slagboom, EP; Styrkársdóttir, U; Tsezou, A; van de Putte, T; Zmuda, J; Spector, TD; Stefansson, K; Uitterlinden, AG; van Meurs, JB. (2010) A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum., 62 (2): 499-510. [PMID:20112360]

4. Lee, J., Hever, A., Willhite, D., Zlotnik, A. and Hevezi, P. (2005) Effects of RNA degradation on gene expression analysis of human postmortem tissues. FASEB J, 19: 1356-1358. [PMID:15955843]

5. O'Dowd, BF; Nguyen, T; Jung, BP; Marchese, A; Cheng, R; Heng, HH; Kolakowski, LF; Lynch, KR; George, SR. (1997) Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes. Gene, 187 (1): 75-81. [PMID:9073069]

6. Valdes, AM; Spector, TD. (2010) The genetic epidemiology of osteoarthritis. Curr Opin Rheumatol, 22 (2): 139-43. [PMID:20090528]

To cite this database page, please use the following:

Amy E. Monaghan.
Class A Orphans: GPR22. Last modified on 31/07/2012. Accessed on 24/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=93.


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