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isopentenyl-diphosphate Δ-isomerase 2

Family: Lanosterol biosynthesis pathway

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Selected 3D Structures
Enzyme Reaction
Cofactors
Tissue Distribution
References
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 227 10p15.3 IDI2 isopentenyl-diphosphate delta isomerase 2
Mouse - 227 13 A1; 13 Idi2 isopentenyl-diphosphate delta isomerase 2
Rat - 227 17q12.1 Idi2 isopentenyl-diphosphate delta isomerase 2
Previous and Unofficial Names
IPPI2
LOC502143
RGD1559783
RGD1559783_predicted
isopentenyl-diphosphate delta isomerase 2
similar to isopentenyl diphosphate delta-isomerase type 2 (predicted)
Database Links
BRENDA 5.3.3.2
Ensembl ENSG00000148377 (Hs), ENSMUSG00000033520 (Mm), ENSRNOG00000032121 (Rn)
Entrez Gene 91734 (Hs), 320581 (Mm), 502143 (Rn)
ExplorEnz 5.3.3.2
GeneCards IDI2 (Hs)
GenitoUrinary Development Molecular Anatomy Project Idi2 (Mm)
Human Protein Reference Database 17127 (Hs)
InterPro Q9BXS1 (Hs), Q8BFZ6 (Mm)
KEGG BRITE Hierarchy 5.3.3.2
KEGG Gene hsa:91734 (Hs), mmu:320581 (Mm), rno:502143 (Rn)
PharmGKB Gene PA134935136 (Hs)
PhosphoSitePlus Q9BXS1 (Hs)
RefSeq Nucleotide NM_033261 (Hs), NM_177197 (Mm), NM_001192008 (Rn)
RefSeq Protein NP_150286 (Hs), NP_796171 (Mm), NP_001178937 (Rn)
TreeFam ENSG00000148377 (Hs), ENSMUSG00000033520 (Mm), ENSRNOG00000032121 (Rn)
UniGene Hs. 591325 (Hs), 9270 (Hs)
UniProt Q9BXS1 (Hs), Q8BFZ6 (Mm)
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Structure of Human Isopentenyl-diphosphate Delta-isomerase 2
PDB Id:  2PNY
Resolution:  1.81Å
Species:  Human
References: 
Search for other structures on the PDB
Search by keyword: Lanosterol biosynthesis pathway isopentenyl-diphosphate Δ-isomerase 2 Search by accession number: Q9BXS1, Q8BFZ6
Enzyme Reaction
EC Number: 5.3.3.2 isopentenyl diphosphate = dimethylallyl diphosphate
Cofactors
Cofactor Species Comments Reference
Mg2+ Human Enzyme activity increases with increasing Mg2+ up to 20mM. 3-4
Mn2+ Human Activity increases up to a concentration of 100 micromolar Mn2+ then sharply decreases. 2-3
Tissue Distribution Comments
Highly expressed in skeletal muscle [1-2].

REFERENCES

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1. Breitling, R; Laubner, D; Clizbe, D; Adamski, J; Krisans, SK. (2003) Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication. J. Mol. Evol., 57 (3): 282-91. [PMID:14629038]

2. Clizbe, DB; Owens, ML; Masuda, KR; Shackelford, JE; Krisans, SK. (2007) IDI2, a second isopentenyl diphosphate isomerase in mammals. J. Biol. Chem., 282 (9): 6668-76. [PMID:17202134]

3. Hahn, FM; Xuan, JW; Chambers, AF; Poulter, CD. (1996) Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization. Arch. Biochem. Biophys., 332 (1): 30-4. [PMID:8806705]

4. Zhang, C; Liu, L; Xu, H; Wei, Z; Wang, Y; Lin, Y; Gong, W. (2007) Crystal structures of human IPP isomerase: new insights into the catalytic mechanism. J. Mol. Biol., 366 (5): 1437-46. [PMID:17137593]

To cite this database page, please use the following:

Helen E. Benson.
Lanosterol biosynthesis pathway: isopentenyl-diphosphate Δ-isomerase 2. Last modified on 01/04/2013. Accessed on 26/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=64704.


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