IUPHAR DATABASE | 1H. Liver X receptor-like receptors

Annotated and expert reviewed. Please contact us if you can help with updates.

Liver X receptor-α

Systematic Nomenclature: NR1H3

Family: 1H. Liver X receptor-like receptors

Contents:

Gene and Protein Information

Previous and Unofficial Names

Database Links

Selected 3D Structures

Physiological Consequences of Altering Gene Expression

Phenotypes, Alleles and Disease Models

Clinically-Relevant Mutations and Pathophysiology

References

Gene and Protein Information
Species	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	447	11p11.2	NR1H3	nuclear receptor subfamily 1, group H, member 3	39
Mouse	445	2 40.4 cM	Nr1h3	nuclear receptor subfamily 1, group H, member 3	1
Rat	445	3q24	Nr1h3	nuclear receptor subfamily 1, group H, member 3	2

Previous and Unofficial Names
LXRα
LXR-a
RLD-1
Oxysterols receptor α
liver X receptor-alpha
LXRalpha
liver X receptor alpha
nuclear orphan receptor LXR-alpha
nuclear receptor subfamily 1, group H, member 3
oxysterols receptor LXR-alpha
LXR alpha
Unr1
AU018371

Previous and Unofficial Names

LXRα

LXR-a

RLD-1

Oxysterols receptor α

liver X receptor-alpha

LXRalpha

liver X receptor alpha

nuclear orphan receptor LXR-alpha

nuclear receptor subfamily 1, group H, member 3

oxysterols receptor LXR-alpha

LXR alpha

Unr1

AU018371

Database Links
ChEMBL Target	11269 (Hs)
Ensembl	ENSG00000025434 (Hs), ENSMUSG00000002108 (Mm), ENSRNOG00000013172 (Rn)
Entrez Gene	10062 (Hs), 22259 (Mm), 58852 (Rn)
GeneCards	NR1H3 (Hs)
GenitoUrinary Development Molecular Anatomy Project	Nr1h3 (Mm)
HomoloGene	21165 (Hs)
Human Protein Reference Database	07211 (Hs)
InterPro	Q13133 (Hs), Q9Z0Y9 (Mm), Q62685 (Rn)
KEGG Gene	hsa:10062 (Hs), mmu:22259 (Mm), rno:58852 (Rn)
NURSA Receptor	1H3
OMIM	602423 (Hs)
Orphanet Gene	ORPHA123908 (Hs)
PharmGKB Gene	PA31751 (Hs)
PhosphoSitePlus	Q13133 (Hs), Q9Z0Y9 (Mm), Q62685 (Rn)
RefSeq Nucleotide	NM_001130102 (Hs), NM_013839 (Mm), NM_001177730 (Mm), NM_031627 (Rn)
RefSeq Protein	NP_005684 (Hs), NP_038867 (Mm), NP_113815 (Rn)
TreeFam	ENSG00000025434 (Hs), ENSMUSG00000002108 (Mm), ENSRNOG00000013172 (Rn)
UniProt	Q13133 (Hs), Q9Z0Y9 (Mm), Q62685 (Rn)
	1H. Liver X receptor-like receptors

Selected 3D Structures

Image of receptor 3D structure from RCSB PDB

Description:	Heteromeric complex of the ligand binding domain of hLXR-alpha receptor and hRXR-alpha
PDB Id:	1UHL
Ligand:	T0901317
Resolution:	2.9Å
Species:	Human
References:	35

Search for other structures on the PDB

Search by keyword: Liver X receptor-α

Search by accession number: Q13133, Q62685, Q9Z0Y9

Natural/Endogenous Ligand(s)
Comments: A series of oxysterols are natural ligands

Potency order (Human)
20S-hydroxycholesterol, 22R-hydroxycholesterol, 24(S)-hydroxycholesterol > 25-hydroxycholesterol, 27-hydroxycholesterol [21]

Potency order (Human)

20S-hydroxycholesterol, 22R-hydroxycholesterol, 24(S)-hydroxycholesterol > 25-hydroxycholesterol, 27-hydroxycholesterol [21]

Agonists

Key to terms and symbols

View all chemical structures

Click column headers to sort

Ligand	Sp.	Action	Affinity	Units	Reference
L-783483	Hs	Agonist	7.9	pK_d	26
acetyl-podocarpic dimer	Hs	Agonist	9.0	pEC₅₀	34
T0901317	Hs	Agonist	7.3	pEC₅₀	31
27-hydroxycholesterol	Hs	Agonist	7.1	pEC₅₀	9
GW3965	Hs	Agonist	6.7	pEC₅₀	6
24(S), 25-epoxycholesterol	Hs	Agonist	5.4	pEC₅₀	13,21
24(S)-hydroxycholesterol	Hs	Agonist	5.4	pEC₅₀	21
paxilline	Hs	Agonist	5.4	pEC₅₀	3
22R-hydroxycholesterol	Hs	Agonist	5.3	pEC₅₀	14

Agonist Comments

Other oxysterols were also identified as endogenous ligands by Janowski et al[14].
Activity of endogenous LXR agonists is compared in Janowski et al[13].
Efficacy value for ligand 27-hydroxycholesterol was determined in vitro.

DNA Binding

Structure:	RXR partner
HRE core sequence:	AGGTCANNNNAGGTCA
Response element:	DR4, Other - see comments

DNA Binding Comments

RXR binds the 5’ half-site while LXR binds the 3’ half-site of DR4 HREs

Co-binding Partners
Name	Interaction	Effect	Reference
Retinoid X receptor-α	Physical, Functional	Required for transactivation	39
SHP	Physical, Functional	Represses transactivation	4
LRH-1	Functional	Competence factor	25

Main Co-regulators
Name	Activity	Specific	Ligand dependent	AF-2 dependent	Comments	References
EP300	Co-activator	No	Yes	No	Overexpression increased transactivation of the ABCA1 promoter	12
NCOA1	Co-activator	No	Yes	No	p160 family: Overexpression increased transactivation of the ABCA1 promoter	12
TRRAP	Co-activator	No	Yes	No	Overexpression increased transactivation of LXRE, RNAi decreased expression of LXR regulated genes	36
NCOA2	Co-activator	No	Yes	No	Interaction determined by affinity pull-down	33
PPARGC1A	Co-activator	No	Yes	No	Overexpression increased transactivation of the CETP promoter	27
PPARGC1B	Co-activator	No	Yes	No	Overexpression increased transactivation of LXRE Viral transduction increased expression of LXR genes	22
NCOR1	Co-repressor	No	Yes	No	Interaction determined in mammalian two-hybrid LXR alpha>beta. Overexpression decreased transactivation of LXRE	10
NCOR2	Co-repressor	No	Yes	No	Interaction determined in mammalian two-hybrid LXR alpha>beta	10

Main Target Genes
Name	Species	Effect	Technique	Comments	References
CETP	Human	Activated	Transient transfection, EMSA		24
ABCA1	Human	Activated	Transient transfection, EMSA		7,29
ABCG1	Human	Activated	Transient transfection, EMSA		17,37
SREBF1	Human	Activated	Transient transfection, EMSA		29
APOE	Human	Activated	Transient transfection, EMSA		20
APOD	Human	Activated	Transient transfection, EMSA		11
LPL	Human	Activated	Transient transfection, EMSA		40
PLTP	Human	Activated	Transient transfection, EMSA		5,18
NR1H3	Human	Activated	Transient transfection, EMSA		19
FAS	Human	Activated	Transient transfection, EMSA		15
SLC2A4	Human	Activated	Transient transfection, EMSA		8
ApoCI/IV/II	Human	Activated	Transient transfection		25
Cyp7a1	Mouse	Activated	Transient transfection, EMSA		21
Vegfa	Mouse	Activated			38

Tissue Distribution

Liver, small intestine, kidney, adipose, macrophages, spleen, adrenal

Expression level:	High
Species:	Rat
Technique:	Northern blot
References:	39

Tissue Distribution Comments

Mouse expression determined by Northern in [23]

Physiological Consequences of Altering Gene Expression

Knockout mice: display an inability to tolerate dietary cholesterol; accumulation of hepatic cholesteryl esters resulting in hepatomegaly; accumulation of macrophage cholesterol; increased serum LDL; decreased serum HDL, VLDL, and triglycerides.

Species:	Mouse
Tissue:
Technique:	Knock-out
References:	28,30-32

Knock out mice: are resistant to obesity when challenged with a diet containing high fat and cholesterol.

Species:	Mouse
Tissue:
Technique:	Knockout
References:	16

Phenotypes, Alleles and Disease Models

Mouse data from MGI

Click here to show/hide data

Allele	Composition & genetic background	Accession	Phenotype Id	Phenotype	Reference
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0002182	abnormal astrocyte morphology	PMID: 12368482
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0005365	abnormal bile salt homeostasis	PMID: 9630215
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0009278	abnormal bone marrow cell physiology	PMID: 12193651
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0010152	abnormal brain ependyma morphology	PMID: 12368482
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0004950	abnormal brain vasculature morphology	PMID: 12368482
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0000822	abnormal brain ventricle morphology	PMID: 12368482
Nr1h3^tm1.1Gstr	Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462	MP:0003191	abnormal cellular cholesterol metabolism	PMID: 11238557
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0005537	abnormal cerebral aqueduct morphology	PMID: 12368482
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0005278	abnormal cholesterol homeostasis	PMID: 12368482
Nr1h3^tm1Dgen	Nr1h3^tm1Dgen/Nr1h3^tm1Dgen Not Specified	MGI:1352462	MP:0005278	abnormal cholesterol homeostasis	PMID: 16614371
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0000820	abnormal choroid plexus morphology	PMID: 12368482
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0002679	abnormal corpus luteum	PMID: 19325005
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0001119	abnormal female reproductive system morphology	PMID: 17166844
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0003699	abnormal female reproductive system physiology	PMID: 17166844
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0000828	abnormal fourth ventricle morphology	PMID: 12368482
Nr1h3^tm1Dgen	Nr1h3^tm1Dgen/Nr1h3^tm1Dgen Not Specified	MGI:1352462	MP:0002139	abnormal hepatobiliary system physiology	PMID: 16614371
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0000823	abnormal lateral ventricle morphology	PMID: 12368482
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0002786	abnormal Leydig cell morphology	PMID: 17341595
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0002118	abnormal lipid homeostasis	PMID: 12368482
Nr1h3^tm1Dgen	Nr1h3^tm1Dgen/Nr1h3^tm1Dgen Not Specified	MGI:1352462	MP:0002118	abnormal lipid homeostasis	PMID: 16614371
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0002446	abnormal macrophage morphology	PMID: 12193651
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0001145	abnormal male reproductive system morphology	PMID: 17166844
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0003698	abnormal male reproductive system physiology	PMID: 17166844
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0009229	abnormal median eminence morphology	PMID: 12368482
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0000920	abnormal myelination	PMID: 12368482
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0003871	abnormal myelin sheath morphology	PMID: 12368482
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0008256	abnormal myometrium morphology	PMID: 17166844
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0003507	abnormal ovary physiology	PMID: 19325005
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0002907	abnormal parturition	PMID: 17166844
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0002216	abnormal seminiferous tubule morphology	PMID: 17341595
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0002784	abnormal Sertoli cell morphology	PMID: 17341595
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0002685	abnormal spermatogonia proliferation	PMID: 17341595
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0009688	abnormal spinal cord central canal morphology	PMID: 12368482
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0000836	abnormal substantia nigra morphology	PMID: 12368482
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0009648	abnormal superovulation	PMID: 19325005
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0000826	abnormal third ventricle morphology	PMID: 12368482
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0009671	abnormal uterus physiology	PMID: 17166844
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0008934	absent choroid plexus	PMID: 12368482
Nr1h3^tm1Djm\|Tg(APPswe,PSEN1dE9)85Dbo	Nr1h3^tm1Djm/Nr1h3^tm1Djm,Tg(APPswe,PSEN1dE9)85Dbo/0 involves: 129S6/SvEvTac * C3H * C57BL/6	MGI:1352462 MGI:3525178	MP:0003329	amyloid beta deposits	PMID: 17563384
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0003354	astrocytosis	PMID: 12368482
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0002773	decreased circulating luteinizing hormone level	PMID: 17341595
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0002773	decreased circulating luteinizing hormone level	PMID: 17341595
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0002780	decreased circulating testosterone level	PMID: 17341595
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0002780	decreased circulating testosterone level	PMID: 17341595
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0008948	decreased neuron number	PMID: 12368482
Nr1h3^tm1Wexi	Nr1h3^tm1Wexi/Nr1h3^tm1Wexi involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:1352462	MP:0008734	decreased susceptibility to endotoxin shock	PMID: 19717840
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0004852	decreased testis weight	PMID: 17341595
Nr1h3^tm1.1Gstr	Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462	MP:0000599	enlarged liver	PMID: 11238557
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0004832	enlarged ovary	PMID: 19325005
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0002628	hepatic steatosis	PMID: 9630215
Nr1h3^tm1Wexi	Nr1h3^tm1Wexi/Nr1h3^tm1Wexi involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:1352462	MP:0002628	hepatic steatosis	PMID: 19717840
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0000755	hindlimb paralysis	PMID: 17166844
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0000740	impaired smooth muscle contractility	PMID: 17166844
Nr1h3^tm1.1Gstr	Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462	MP:0002941	increased circulating alanine transaminase level	PMID: 11238557
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0002941	increased circulating alanine transaminase level	PMID: 9630215
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0005343	increased circulating aspartate transaminase level	PMID: 9630215
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0005178	increased circulating cholesterol level	PMID: 9630215
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0005182	increased circulating estradiol level	PMID: 19325005
Nr1h3^tm1.1Gstr	Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462	MP:0000182	increased circulating LDL cholesterol level	PMID: 11238557
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0000182	increased circulating LDL cholesterol level	PMID: 9630215
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0001846	increased inflammatory response	PMID: 19325005
Nr1h3^tm1.1Gstr	Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462	MP:0010027	increased liver cholesterol level	PMID: 11238557
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0010027	increased liver cholesterol level	PMID: 9630215
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac	MGI:1352462 MGI:1352463	MP:0010027	increased liver cholesterol level	PMID: 10968783
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0002981	increased liver weight	PMID: 9630215
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0004778	increased macrophage derived foam cell number	PMID: 12368482
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0009763	increased sensitivity to induced morbidity/mortality	PMID: 12524534
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0009763	increased sensitivity to induced morbidity/mortality	PMID: 12524534
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0002412	increased susceptibility to bacterial infection	PMID: 12524534
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0002412	increased susceptibility to bacterial infection	PMID: 12524534
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0003070	increased vascular permeability	PMID: 19325005
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0001915	intracranial hemorrhage	PMID: 12368482
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0003103	liver degeneration	PMID: 9630215
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0008280	male germ cell apoptosis	PMID: 17341595
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0008280	male germ cell apoptosis	PMID: 17341595
Nr1h2^tm1.1Gstr\|Nr1h3^tm1.1Gstr	Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr,Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462 MGI:1352463	MP:0003224	neuron degeneration	PMID: 12368482
Nr1h3^tm1Gstr	Nr1h3^tm1Gstr/Nr1h3^tm1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462	MP:0002169	no abnormal phenotype detected	PMID: 11238557
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0002016	ovary cysts	PMID: 19325005
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0004834	ovary hemorrhage	PMID: 19325005
Nr1h3^tm1.1Gstr	Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:1352462	MP:0000603	pale liver	PMID: 11238557
Nr1h3^tm1Djm	Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462	MP:0000603	pale liver	PMID: 9630215
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0008028	pregnancy-related premature death	PMID: 17166844
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0001922	reduced male fertility	PMID: 17341595
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0001154	seminiferous tubule degeneration	PMID: 17341595
Nr1h2^tm1Djm\|Nr1h3^tm1Djm	Nr1h2^tm1Djm/Nr1h2^tm1Djm,Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	MGI:1352462 MGI:1352463	MP:0003205	testicular atrophy	PMID: 17341595

Clinically-Relevant Mutations and Pathophysiology

Disease:	Amyotrophic lateral sclerosis
Orphanet:	803
References:

Mutations not determined

REFERENCES

Show »« Hide

1. Alberti, S; Steffensen, KR; Gustafsson, JA. (2000) Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta. Gene, 243 (1-2): 93-103. [PMID:10675617]

2. Apfel, R; Benbrook, D; Lernhardt, E; Ortiz, MA; Salbert, G; Pfahl, M. (1994) A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol. Cell. Biol., 14 (10): 7025-35. [PMID:7935418]

3. Bramlett, KS; Houck, KA; Borchert, KM; Dowless, MS; Kulanthaivel, P; Zhang, Y; Beyer, TP; Schmidt, R; Thomas, JS; Michael, LF; Barr, R; Montrose, C; Eacho, PI; Cao, G; Burris, TP. (2003) A natural product ligand of the oxysterol receptor, liver X receptor. J. Pharmacol. Exp. Ther., 307 (1): 291-6. [PMID:12893846]

4. Brendel, C; Schoonjans, K; Botrugno, OA; Treuter, E; Auwerx, J. (2002) The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity. Mol. Endocrinol., 16 (9): 2065-76. [PMID:12198243]

5. Cao, G; Beyer, TP; Yang, XP; Schmidt, RJ; Zhang, Y; Bensch, WR; Kauffman, RF; Gao, H; Ryan, TP; Liang, Y; Eacho, PI; Jiang, XC. (2002) Phospholipid transfer protein is regulated by liver X receptors in vivo. J. Biol. Chem., 277 (42): 39561-5. [PMID:12177004]

6. Collins, JL; Fivush, AM; Watson, MA; Galardi, CM; Lewis, MC; Moore, LB; Parks, DJ; Wilson, JG; Tippin, TK; Binz, JG; Plunket, KD; Morgan, DG; Beaudet, EJ; Whitney, KD; Kliewer, SA; Willson, TM. (2002) Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J. Med. Chem., 45 (10): 1963-6. [PMID:11985463]

7. Costet, P; Luo, Y; Wang, N; Tall, AR. (2000) Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J. Biol. Chem., 275 (36): 28240-5. [PMID:10858438]

8. Dalen, KT; Ulven, SM; Bamberg, K; Gustafsson, JA; Nebb, HI. (2003) Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha. J. Biol. Chem., 278 (48): 48283-91. [PMID:12970362]

9. Fu, X; Menke, JG; Chen, Y; Zhou, G; MacNaul, KL; Wright, SD; Sparrow, CP; Lund, EG. (2001) 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J. Biol. Chem., 276 (42): 38378-87. [PMID:11504730]

10. Hu, X; Li, S; Wu, J; Xia, C; Lala, DS. (2003) Liver X receptors interact with corepressors to regulate gene expression. Mol. Endocrinol., 17 (6): 1019-26. [PMID:12663743]

11. Hummasti, S; Laffitte, BA; Watson, MA; Galardi, C; Chao, LC; Ramamurthy, L; Moore, JT; Tontonoz, P. (2004) Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target. J. Lipid Res., 45 (4): 616-25. [PMID:14703507]

12. Huuskonen, J; Fielding, PE; Fielding, CJ. (2004) Role of p160 coactivator complex in the activation of liver X receptor. Arterioscler. Thromb. Vasc. Biol., 24 (4): 703-8. [PMID:14764426]

13. Janowski, BA; Grogan, MJ; Jones, SA; Wisely, GB; Kliewer, SA; Corey, EJ; Mangelsdorf, DJ. (1999) Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc. Natl. Acad. Sci. U.S.A., 96 (1): 266-71. [PMID:9874807]

14. Janowski, BA; Willy, PJ; Devi, TR; Falck, JR; Mangelsdorf, DJ. (1996) An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature, 383 (6602): 728-31. [PMID:8878485]

15. Joseph, SB; Laffitte, BA; Patel, PH; Watson, MA; Matsukuma, KE; Walczak, R; Collins, JL; Osborne, TF; Tontonoz, P. (2002) Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J. Biol. Chem., 277 (13): 11019-25. [PMID:11790787]

16. Kalaany, NY; Gauthier, KC; Zavacki, AM; Mammen, PP; Kitazume, T; Peterson, JA; Horton, JD; Garry, DJ; Bianco, AC; Mangelsdorf, DJ. (2005) LXRs regulate the balance between fat storage and oxidation. Cell Metab., 1 (4): 231-44. [PMID:16054068]

17. Kennedy, MA; Venkateswaran, A; Tarr, PT; Xenarios, I; Kudoh, J; Shimizu, N; Edwards, PA. (2001) Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein. J. Biol. Chem., 276 (42): 39438-47. [PMID:11500512]

18. Laffitte, BA; Joseph, SB; Chen, M; Castrillo, A; Repa, J; Wilpitz, D; Mangelsdorf, D; Tontonoz, P. (2003) The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions. Mol. Cell. Biol., 23 (6): 2182-91. [PMID:12612088]

19. Laffitte, BA; Joseph, SB; Walczak, R; Pei, L; Wilpitz, DC; Collins, JL; Tontonoz, P. (2001) Autoregulation of the human liver X receptor alpha promoter. Mol. Cell. Biol., 21 (22): 7558-68. [PMID:11604492]

20. Laffitte, BA; Repa, JJ; Joseph, SB; Wilpitz, DC; Kast, HR; Mangelsdorf, DJ; Tontonoz, P. (2001) LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc. Natl. Acad. Sci. U.S.A., 98 (2): 507-12. [PMID:11149950]

21. Lehmann, JM; Kliewer, SA; Moore, LB; Smith-Oliver, TA; Oliver, BB; Su, JL; Sundseth, SS; Winegar, DA; Blanchard, DE; Spencer, TA; Willson, TM. (1997) Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem., 272 (6): 3137-40. [PMID:9013544]

22. Lin, J; Yang, R; Tarr, PT; Wu, PH; Handschin, C; Li, S; Yang, W; Pei, L; Uldry, M; Tontonoz, P; Newgard, CB; Spiegelman, BM. (2005) Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell, 120 (2): 261-73. [PMID:15680331]

23. Lu, TT; Repa, JJ; Mangelsdorf, DJ. (2001) Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J. Biol. Chem., 276 (41): 37735-8. [PMID:11459853]

24. Luo, Y; Tall, AR. (2000) Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element. J. Clin. Invest., 105 (4): 513-20. [PMID:10683381]

25. Mak, PA; Laffitte, BA; Desrumaux, C; Joseph, SB; Curtiss, LK; Mangelsdorf, DJ; Tontonoz, P; Edwards, PA. (2002) Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. J. Biol. Chem., 277 (35): 31900-8. [PMID:12032151]

26. Menke, JG; Macnaul, KL; Hayes, NS; Baffic, J; Chao, YS; Elbrecht, A; Kelly, LJ; Lam, MH; Schmidt, A; Sahoo, S; Wang, J; Wright, SD; Xin, P; Zhou, G; Moller, DE; Sparrow, CP. (2002) A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). Endocrinology, 143 (7): 2548-58. [PMID:12072387]

27. Oberkofler, H; Schraml, E; Krempler, F; Patsch, W. (2003) Potentiation of liver X receptor transcriptional activity by peroxisome-proliferator-activated receptor gamma co-activator 1 alpha. Biochem. J., 371 (Pt 1): 89-96. [PMID:12470296]

28. Peet, DJ; Turley, SD; Ma, W; Janowski, BA; Lobaccaro, JM; Hammer, RE; Mangelsdorf, DJ. (1998) Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell, 93 (5): 693-704. [PMID:9630215]

29. Repa, JJ; Liang, G; Ou, J; Bashmakov, Y; Lobaccaro, JM; Shimomura, I; Shan, B; Brown, MS; Goldstein, JL; Mangelsdorf, DJ. (2000) Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev., 14 (22): 2819-30. [PMID:11090130]

30. Repa, JJ; Turley, SD; Lobaccaro, JA; Medina, J; Li, L; Lustig, K; Shan, B; Heyman, RA; Dietschy, JM; Mangelsdorf, DJ. (2000) Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science, 289 (5484): 1524-9. [PMID:10968783]

31. Schultz, JR; Tu, H; Luk, A; Repa, JJ; Medina, JC; Li, L; Schwendner, S; Wang, S; Thoolen, M; Mangelsdorf, DJ; Lustig, KD; Shan, B. (2000) Role of LXRs in control of lipogenesis. Genes Dev., 14 (22): 2831-8. [PMID:11090131]

32. Schuster, GU; Parini, P; Wang, L; Alberti, S; Steffensen, KR; Hansson, GK; Angelin, B; Gustafsson, JA. (2002) Accumulation of foam cells in liver X receptor-deficient mice. Circulation, 106 (9): 1147-53. [PMID:12196343]

33. Song, C; Kokontis, JM; Hiipakka, RA; Liao, S. (1994) Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors. Proc. Natl. Acad. Sci. U.S.A., 91 (23): 10809-13. [PMID:7971966]

34. Sparrow, CP; Baffic, J; Lam, MH; Lund, EG; Adams, AD; Fu, X; Hayes, N; Jones, AB; Macnaul, KL; Ondeyka, J; Singh, S; Wang, J; Zhou, G; Moller, DE; Wright, SD; Menke, JG. (2002) A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux. J. Biol. Chem., 277 (12): 10021-7. [PMID:11790770]

35. Svensson, S; Ostberg, T; Jacobsson, M; Norström, C; Stefansson, K; Hallén, D; Johansson, IC; Zachrisson, K; Ogg, D; Jendeberg, L. (2003) Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation. EMBO J., 22 (18): 4625-33. [PMID:12970175]

36. Unno, A; Takada, I; Takezawa, S; Oishi, H; Baba, A; Shimizu, T; Tokita, A; Yanagisawa, J; Kato, S. (2005) TRRAP as a hepatic coactivator of LXR and FXR function. Biochem. Biophys. Res. Commun., 327 (3): 933-8. [PMID:15649435]

37. Venkateswaran, A; Repa, JJ; Lobaccaro, JM; Bronson, A; Mangelsdorf, DJ; Edwards, PA. (2000) Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. J. Biol. Chem., 275 (19): 14700-7. [PMID:10799558]

38. Walczak, R; Joseph, SB; Laffitte, BA; Castrillo, A; Pei, L; Tontonoz, P. (2004) Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors. J. Biol. Chem., 279 (11): 9905-11. [PMID:14699103]

39. Willy, PJ; Umesono, K; Ong, ES; Evans, RM; Heyman, RA; Mangelsdorf, DJ. (1995) LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev., 9 (9): 1033-45. [PMID:7744246]

40. Zhang, Y; Repa, JJ; Gauthier, K; Mangelsdorf, DJ. (2001) Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta. J. Biol. Chem., 276 (46): 43018-24. [PMID:11562371]

To cite this database page, please use the following:

1H. Liver X receptor-like receptors: Liver X receptor-α. Last modified on 01/03/2012. Accessed on 21/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=602.

1H. Liver X receptor-like receptors
	Introduction
	Contributors
	References
	Farnesoid X receptor
	Farnesoid X receptor-β
	Liver X receptor-α
	Liver X receptor-β