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Kv12.1
Family: Voltage-gated potassium channels
| Gene and Protein Information |
| Species |
TM |
P Loops |
AA |
Chromosomal Location |
Gene Symbol |
Gene Name |
Reference |
| Human |
6 |
1 |
1107 |
3p24.3 |
KCNH8
|
potassium voltage-gated channel, subfamily H (eag-related), member 8
|
|
| Mouse |
6 |
1 |
1102 |
17 C |
Kcnh8
|
potassium voltage-gated channel, subfamily H (eag-related), member 8
|
|
| Rat |
6 |
1 |
1102 |
9q11 |
Kcnh8
|
potassium voltage-gated channel, subfamily H (eag-related), member 8
|
|
| Previous and Unofficial Names |
| elk1 |
| elk3 |
| Kv12.1 |
| Ets-1 |
| ELK channel 3 |
| ELK1, member of ETS oncogene family |
| ether-a-go-go-like potassium channel 1 |
| ether-a-go-go-like potassium channel 3 |
| potassium voltage-gated channel subfamily H member 8 |
| potassium voltage-gated channel, subfamily H, member 8 |
| voltage-gated potassium channel subunit Kv12.1 |
| C130090D05Rik |
| Database Links |
|
Ensembl
|
ENSG00000183960 (Hs), ENSMUSG00000035580 (Mm), ENSMUSG00000073383 (Mm), ENSRNOG00000012711 (Rn)
|
|
Entrez Gene
|
131096 (Hs), 211468 (Mm), 246325 (Rn)
|
|
GeneCards
|
KCNH8 (Hs)
|
|
GenitoUrinary Development Molecular Anatomy Project
|
Kcnh8 (Mm)
|
|
HomoloGene
|
14332 (Hs)
|
|
Human Protein Reference Database
|
10006 (Hs)
|
|
InterPro
|
Q96L42 (Hs), P59111 (Mm), Q9QWS8 (Rn)
|
|
KEGG Gene
|
hsa:131096 (Hs), mmu:211468 (Mm), rno:246325 (Rn)
|
|
OMIM
|
608260 (Hs)
|
|
PharmGKB Gene
|
PA38724 (Hs)
|
|
PhosphoSitePlus
|
Q96L42 (Hs), P59111 (Mm)
|
|
Protein Ontology (PRO)
|
PRO:000000797 (Hs)
|
|
RefSeq Nucleotide
|
NM_144633 (Hs), NM_001031811 (Mm), NM_145095 (Rn)
|
|
RefSeq Protein
|
NP_653234 (Hs), NP_001026981 (Mm), NP_659563 (Rn)
|
|
TreeFam
|
ENSG00000183960 (Hs), ENSMUSG00000035580 (Mm), ENSMUSG00000073383 (Mm), ENSRNOG00000012711 (Rn)
|
|
UniGene Hs.
|
475656 (Hs)
|
|
UniProt
|
Q96L42 (Hs), P59111 (Mm), Q9QWS8 (Rn)
|
|
Wikipedia
|
Kv12.1
|
|
Potassium channels
|
| Search for 3D structures on the PDB |
|
Search by keyword:
Voltage-gated potassium channels Kv12.1
|
Search by accession number: Q9QWS8, P59111, Q96L42
|
| Ion Selectivity and Conductance |
| Species: |
Human |
| Macroscopic current rectification: |
Ik |
| References: |
3 |
|
| Voltage Dependence |
| |
V0.5 (mV) |
τ (msec) |
Reference |
Cell type |
Species |
| Activation |
9.0 |
- |
2 |
Xenopus laevis Oocytes |
Rat |
| Inactivation |
- |
- |
|
| Comments |
Voltage sensitivity is sensitive to internal pH:
V0.5=10mV at pH 7.7
V0.5=28mV at pH 6.6 [2] |
|
| |
V0.5 (mV) |
τ (msec) |
Reference |
Cell type |
Species |
| Activation |
-62.0 |
259.0 – 45.0 |
3 |
Xenopus laevis Oocytes |
Human |
| Inactivation |
- |
- |
|
| Deactivation |
- |
331.0 – 66.0 |
3 |
|
|
Associated subunits
(Human)
|
|
minK
|
| Tissue Distribution
|
| Primarily expressed in nervous system, especially prominent in the forebrain, cerebral cortex, hippocampus, amygdala, caudate, and nucleus accumbens. KCNH8 and KCNH3 genes also expressed together in the thalamus, substantia nigra, pons, and cerebellum; however the balance of expression level is shifted toward KCNH8. Expression very low in nonneuronal tissues. |
| Species: |
Human |
| Technique: |
RT-PCR |
| References: |
3 |
|
|
| Caudate / putamen, accumbens nuclei > cerebral cortex |
| Species: |
Rat |
| Technique: |
In situ hybridisation |
| References: |
1 |
|
|
| Functional Assays
|
| Voltage clamp of heterologously expressed Kv12.1 currents |
| Species: |
Human |
| Tissue: |
Xenopus laevis oocytes |
| Response measured: |
K+-selective channel, co-assembly with Kv12.2 and Kv12.3 |
| References: |
3 |
|
|
| Voltage clamp of heterologously expressed Kv12.1 currents |
| Species: |
Rat |
| Tissue: |
Xenopus laevis oocytes |
| Response measured: |
Slowly activating outward rectifier
|
| References: |
2 |
|
|
|
General Comments
|
|
The carboxy terminus contains a region with homology to cyclic nucleotide binding domains.
|
REFERENCES
Show »« Hide
1. Saganich, MJ; Machado, E; Rudy, B. (2001) Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain.
J. Neurosci., 21 (13): 4609-24.
[PMID:11425889]
2. Shi, W; Wang, HS; Pan, Z; Wymore, RS; Cohen, IS; McKinnon, D; Dixon, JE. (1998) Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia.
J. Physiol. (Lond.), 511 ( Pt 3): 675-82.
[PMID:9714851]
3. Zou, A; Lin, Z; Humble, M; Creech, CD; Wagoner, PK; Krafte, D; Jegla, TJ; Wickenden, AD. (2003) Distribution and functional properties of human KCNH8 (Elk1) potassium channels.
Am. J. Physiol., Cell Physiol., 285 (6): C1356-66.
[PMID:12890647]
To cite this database page, please use the following:
K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv12.1. Last modified on 01/07/2010. Accessed on 19/06/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=575.
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