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Kv11.2

Family: Voltage-gated potassium channels

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Ion Selectivity and Conductance
Voltage Dependence
Activators
Gating Inhibitors
Pore Blockers
Tissue Distribution
Physiological Functions
Biologically Significant Variants
References
Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 994 17q23.3 KCNH6 potassium voltage-gated channel, subfamily H (eag-related), member 6
Mouse 6 1 950 11 E1 Kcnh6 potassium voltage-gated channel, subfamily H (eag-related), member 6
Rat 6 1 950 10q32.1 Kcnh6 potassium voltage-gated channel, subfamily H (eag-related), member 6
Previous and Unofficial Names
erg2
KCNH6
Kv11.2
HERG2
ERG-2
Eag-related gene member 2
eag-related protein 2
ether-a-go-go-related gene potassium channel 2
ether-a-go-go-related protein 2
potassium voltage-gated channel subfamily H member 6
voltage-gated potassium channel subunit Kv11.2
m-erg2
Database Links
DrugBank Target 514 (Hs)
Ensembl ENSG00000173826 (Hs), ENSMUSG00000001901 (Mm), ENSRNOG00000008078 (Rn)
Entrez Gene 81033 (Hs), 192775 (Mm), 116745 (Rn)
GeneCards KCNH6 (Hs)
GenitoUrinary Development Molecular Anatomy Project Kcnh6 (Mm)
HomoloGene 32740 (Hs)
Human Protein Reference Database 16294 (Hs)
InterPro Q9H252 (Hs), O54853 (Rn)
KEGG Gene hsa:81033 (Hs), mmu:192775 (Mm), rno:116745 (Rn)
OMIM 608168 (Hs)
PharmGKB Gene PA38722 (Hs)
PhosphoSitePlus Q9H252 (Hs), O54853 (Rn)
Protein Ontology (PRO) PRO:000000795 (Hs)
RefSeq Nucleotide NM_173092 (Hs), NM_030779 (Hs), NM_001037712 (Mm), NM_053937 (Rn)
RefSeq Protein NP_775115 (Hs), NP_110406 (Hs), NP_001032801 (Mm), NP_446389 (Rn)
TreeFam ENSG00000173826 (Hs), ENSMUSG00000001901 (Mm), ENSRNOG00000008078 (Rn)
UniGene Hs. 608168 (Hs)
UniProt Q9H252 (Hs), O54853 (Rn)
Wikipedia Kv11.2
Potassium channels
Search for 3D structures on the PDB
Search by keyword: Voltage-gated potassium channels Kv11.2 Search by accession number: Q9H252, O54853
Ion Selectivity and Conductance
Species:  Rat
Macroscopic current rectification:  Ik
References:  6,8
Voltage Dependence
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -3.5 4.0 6 Xenopus laevis oocyte Rat
Inactivation  - 100.0 6
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  - 428.0 8 CHO cells. Rat
Inactivation  - -
Comments  Data for heteromultimers of Kv11.2 and Kv11.3 [8]
Associated subunits (Human)
minK
Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Affinity Units Concentration range (M) Holding voltage (mV) Reference
NS1643 Hs 4.9 pEC50 - - 1
Activator Comments
NS1643: Negative shift of activation curve, slows inactivation. These effects are distinct from those of the same compound on Kv11.1 [1]
Gating inhibitors
Key to terms and symbols Click column headers to sort
Ligand Sp. Affinity Units Concentration range (M) Holding voltage (mV) Reference
ErgTx-1 Rn 8.5 pKd - - 6
BeKm-1 Rn 8.1 pKd - - 6
Gating Inhibitor Comments
For a review of toxin sensitivity among Kv11 channels, see [7]
Pore Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Affinity Units Concentration range (M) Holding voltage (mV) Reference
E4031 Rn 6.9 pKd - - 6
Tissue Distribution
Transiently expressed in the developing embryonic spinal cord, largely within GABAergic neurons
Species:  Mouse
Technique:  Immunocytochemistry, immunofluorescence
References:  2
Pancreatic islet cells
Species:  Rat
Technique:  quantitative RT-PCR, immunocytochemistry, electrophysiology
References:  5
The celiac ganglia (CG), the superior mesenteric ganglia (SMG), retina
Species:  Rat
Technique:  In situ hybridisation
References:  6
Tissue Distribution Comments
Kv11.1, Kv11.2 and Kv11.3 are broadly expressed in the nervous system [6,9]. In the developing embryonic spinal cord, they regulate nascent spinal motor rhythms [3]. All are expressed in the adult brain in largely overlapping distributions and largely in neuron somata [4].
Physiological Functions
Kv11.2 (and Kv11.3) regulate nascent spinal motor rhythms in developing mouse spinal cord
Species:  Mouse
Tissue:  Organotypic slice cultures of spinal cord and dorsal root ganglia (DRG)
References:  3
All Kv11 transcripts are found in pancreatic islet cells and are under differential spatial and circadian regulation
Species:  Rat
Tissue:  Pancreatic Islet cells
References:  5
Biologically Significant Variants
Kv11.2 isoform 2
Nucleotide accession:  NM_173092 
Protein accession:  NP_775115 
Amino acids:  905
Type:  Splice variant
Species:  Human
References: 
Kv11.2 isoform 1
Nucleotide accession:  NM_030779 
Protein accession:  NP_110406 
Amino acids:  994
Type:  Splice variant
Species:  Human
References: 

REFERENCES

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1. Elmedyb, P; Olesen, SP; Grunnet, M. (2007) Activation of ERG2 potassium channels by the diphenylurea NS1643. Neuropharmacology, 53 (2): 283-94. [PMID:17610913]

2. Furlan, F; Guasti, L; Avossa, D; Becchetti, A; Cilia, E; Ballerini, L; Arcangeli, A. (2005) Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro. Neuroscience, 135 (4): 1179-92. [PMID:16165280]

3. Furlan, F; Taccola, G; Grandolfo, M; Guasti, L; Arcangeli, A; Nistri, A; Ballerini, L. (2007) ERG conductance expression modulates the excitability of ventral horn GABAergic interneurons that control rhythmic oscillations in the developing mouse spinal cord. J. Neurosci., 27 (4): 919-28. [PMID:17251434]

4. Guasti, L; Cilia, E; Crociani, O; Hofmann, G; Polvani, S; Becchetti, A; Wanke, E; Tempia, F; Arcangeli, A. (2005) Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits. J. Comp. Neurol., 491 (2): 157-74. [PMID:16127690]

5. Mühlbauer, E; Bazwinsky, I; Wolgast, S; Klemenz, A; Peschke, E. (2007) Circadian changes of ether-a-go-go-related-gene (Erg) potassium channel transcripts in the rat pancreas and beta-cell. Cell. Mol. Life Sci., 64 (6): 768-80. [PMID:17322986]

6. Shi, W; Wymore, RS; Wang, HS; Pan, Z; Cohen, IS; McKinnon, D; Dixon, JE. (1997) Identification of two nervous system-specific members of the erg potassium channel gene family. J. Neurosci., 17 (24): 9423-32. [PMID:9390998]

7. Wanke, E; Restano-Cassulini, R. (2007) Toxins interacting with ether-à-go-go-related gene voltage-dependent potassium channels. Toxicon, 49 (2): 239-48. [PMID:17097705]

8. Wimmers, S; Bauer, CK; Schwarz, JR. (2002) Biophysical properties of heteromultimeric erg K+ channels. Pflugers Arch., 445 (3): 423-30. [PMID:12466946]

9. Wymore, RS; Gintant, GA; Wymore, RT; Dixon, JE; McKinnon, D; Cohen, IS. (1997) Tissue and species distribution of mRNA for the IKr-like K+ channel, erg. Circ. Res., 80 (2): 261-8. [PMID:9012748]

To cite this database page, please use the following:

K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv11.2. Last modified on 01/07/2010. Accessed on 20/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=573.


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