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Kv9.1
Family: Voltage-gated potassium channels
| Gene and Protein Information |
| Species |
TM |
P Loops |
AA |
Chromosomal Location |
Gene Symbol |
Gene Name |
Reference |
| Human |
6 |
1 |
526 |
20q12 |
KCNS1
|
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
|
3 |
| Mouse |
6 |
1 |
497 |
2 H3 |
Kcns1
|
K+ voltage-gated channel, subfamily S, 1
|
|
| Rat |
6 |
1 |
497 |
3q42 |
Kcns1
|
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
|
|
| Previous and Unofficial Names |
| Kv9.1 |
| K+ voltage-gated channel, subfamily S, 1 |
| delayed-rectifier K(+) channel alpha subunit 1 |
| potassium voltage-gated channel subfamily S member 1 |
| potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 |
| voltage-gated potassium channel subunit Kv9.1 |
| Database Links |
|
Ensembl
|
ENSG00000124134 (Hs), ENSMUSG00000040164 (Mm), ENSRNOG00000013681 (Rn)
|
|
Entrez Gene
|
3787 (Hs), 16538 (Mm), 117023 (Rn)
|
|
GeneCards
|
KCNS1 (Hs)
|
|
GenitoUrinary Development Molecular Anatomy Project
|
Kcns1 (Mm)
|
|
HomoloGene
|
20517 (Hs)
|
|
Human Protein Reference Database
|
04214 (Hs)
|
|
InterPro
|
Q96KK3 (Hs), O35173 (Mm), O88758 (Rn)
|
|
KEGG Gene
|
hsa:3787 (Hs), mmu:16538 (Mm), rno:117023 (Rn)
|
|
OMIM
|
602905 (Hs)
|
|
PharmGKB Gene
|
PA30078 (Hs)
|
|
PhosphoSitePlus
|
Q96KK3 (Hs), O35173 (Mm), O88758 (Rn)
|
|
Protein Ontology (PRO)
|
PRO:000000798 (Hs)
|
|
RefSeq Nucleotide
|
NM_002251 (Hs), NM_008435 (Mm), NM_053954 (Rn)
|
|
RefSeq Protein
|
NP_002242 (Hs), NP_032461 (Mm), NP_446406 (Rn)
|
|
TreeFam
|
ENSG00000124134 (Hs), ENSMUSG00000040164 (Mm), ENSRNOG00000013681 (Rn)
|
|
UniGene Hs.
|
117780 (Hs)
|
|
UniProt
|
Q96KK3 (Hs), O35173 (Mm), O88758 (Rn)
|
|
Wikipedia
|
Kv9.1
|
|
Potassium channels
|
| Search for 3D structures on the PDB |
|
Search by keyword:
Voltage-gated potassium channels Kv9.1
|
Search by accession number: O88758, O35173, Q96KK3
|
| Associated Proteins |
| Heteromeric Pore-forming Subunits |
| Name |
References |
| Kv2 |
3 |
|
| Auxiliary Subunits |
| Name |
References |
| Not determined |
|
| Other Associated Proteins |
| Name |
References |
| Not determined |
|
| Ion Selectivity and Conductance |
| Species: |
None |
| Macroscopic current rectification: |
Modifiers/ Silencer |
| References: |
|
|
| Ion Selectivity and Conductance Comments |
| Electrically silent on its own. |
| Tissue Distribution
|
| Infant brain, adult brain (frontal cortex), lens epithelium, melanocytes |
| Species: |
Human |
| Technique: |
RT-PCR |
| References: |
3 |
|
|
| Main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei, cerebellum. |
| Species: |
Mouse |
| Technique: |
Northern Blot, in situ hybridization |
| References: |
2 |
|
|
| Brain |
| Species: |
Rat |
| Technique: |
Northern Blot |
| References: |
4 |
|
|
| Tissue Distribution Comments |
| A very similar localization of Kv9 and Kv2 subunits has been observed at the cellular level in granular cells of the olfactory bulb, Purkinje and granular cells of the cerebellum, pyramidal cells of the hippocampus, and in granular cells of the dentate gyrus [2] |
| Physiological Functions
|
| Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium current. Kv9.1 modulates the activity of Kv2.1 and Kv2.2 α subunits by changing kinetics and levels of expression and by shifting the half-inactivation potential to more polarised values, and enhances the single-channel conductance of Kv2.1. |
| Species: |
Mouse |
| Tissue: |
COS m6 cells |
| References: |
1-2 |
|
|
|
General Comments
|
|
The human Kv9.1 gene is composed of a minimum of 5 exons, with at least 2 alternatively spliced exons in the 5' - untranslated region [1-4].
|
REFERENCES
Show »« Hide
1. Richardson, FC; Kaczmarek, LK. (2000) Modification of delayed rectifier potassium currents by the Kv9.1 potassium channel subunit.
Hear. Res., 147 (1-2): 21-30.
[PMID:10962170]
2. Salinas, M; Duprat, F; Heurteaux, C; Hugnot, JP; Lazdunski, M. (1997) New modulatory alpha subunits for mammalian Shab K+ channels.
J. Biol. Chem., 272 (39): 24371-9.
[PMID:9305895]
3. Shepard, AR; Rae, JL. (1999) Electrically silent potassium channel subunits from human lens epithelium.
Am. J. Physiol., 277 (3 Pt 1): C412-24.
[PMID:10484328]
4. Stocker, M; Kerschensteiner, D. (1998) Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain.
Biochem. Biophys. Res. Commun., 248 (3): 927-34.
[PMID:9704029]
To cite this database page, please use the following:
K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv9.1. Last modified on 01/07/2010. Accessed on 24/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=567.
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