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Kv5.1

Family: Voltage-gated potassium channels

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Ion Selectivity and Conductance
Tissue Distribution
Functional Assays
Physiological Functions
General Comments
References
Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 494 2p25 KCNF1 potassium voltage-gated channel, subfamily F, member 1 4
Mouse 6 1 505 12 A1.1 Kcnf1 potassium voltage-gated channel, subfamily F, member 1
Rat 6 1 505 6q16 Kcnf1 potassium voltage-gated channel, subfamily F, member 1
Previous and Unofficial Names
KH1
IK8
KCNF
Kv5.1
potassium voltage-gated channel, subfamily F, member 1
LOC382571
Gm1182
Database Links
Ensembl ENSG00000162975 (Hs), ENSMUSG00000051726 (Mm), ENSRNOG00000024310 (Rn)
Entrez Gene 3754 (Hs), 382571 (Mm), 298908 (Rn)
GeneCards KCNF1 (Hs)
GenitoUrinary Development Molecular Anatomy Project Kcnf1 (Mm)
HomoloGene 1685 (Hs)
Human Protein Reference Database 04808 (Hs)
InterPro Q9H3M0 (Hs), Q7TSH7 (Mm)
KEGG Gene hsa:3754 (Hs), mmu:382571 (Mm), rno:298908 (Rn)
OMIM 603787 (Hs)
PharmGKB Gene PA30033 (Hs)
PhosphoSitePlus Q9H3M0 (Hs), Q7TSH7 (Mm)
Protein Ontology (PRO) PRO:000000724 (Hs)
RefSeq Nucleotide NM_002236 (Hs), NM_201531 (Mm), NM_001169104 (Rn)
RefSeq Protein NP_002227 (Hs), NP_963289 (Mm), NP_001162575 (Rn)
TreeFam ENSG00000162975 (Hs), ENSMUSG00000051726 (Mm), ENSRNOG00000024310 (Rn)
UniGene Hs. 23735 (Hs)
UniProt Q9H3M0 (Hs), Q7TSH7 (Mm)
Wikipedia Kv5.1
Potassium channels
Search for 3D structures on the PDB
Search by keyword: Voltage-gated potassium channels Kv5.1 Search by accession number: Q7TSH7, Q9H3M0
Ion Selectivity and Conductance
Species:  None
Macroscopic current rectification:  Modifier
References: 
Tissue Distribution
Urinary bladder smooth muscle myocytes.
Species:  Mouse
Technique:  RT-PCR
References:  5
Brain: deeper cortical laters, piriform cortex, olfactory tubercule, medial habenular nucleus, medial amygdaloid nuclei, lateral amygdaloid area > hippocampus, dentate gyrus, zona incerta.
Species:  Rat
Technique:  In situ hybridisation
References:  1,6
Heart.
Species:  Rat
Technique:  Northern Blot
References:  1,6
Skeletal muscle.
Species:  Rat
Technique:  Northern Blot
References:  1,6
Liver, kidney, pancreas.
Species:  Rat
Technique:  Northern Blot
References:  1,6
Functional Assays
Voltage-clamp of KV2.1 and KV5.1 heteromultimers expressed in Xenopus oocytes.
Species:  Rat
Tissue:  Xenopus laevis oocytes.
Response measured:  Modulation of KV2.1 deactivation and inactivation.
References:  2
Physiological Functions
Modifies the gating properties of KV2.1 and KV2.2 channels.
Species:  Rat
Tissue:  Heteromultimers with KV2 subunits.
References:  2-3
General Comments
KV5.1 has no function on its own, but has important modulatory actions on KV2 channels [2-3].

REFERENCES

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1. Drewe, JA; Verma, S; Frech, G; Joho, RH. (1992) Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies. J. Neurosci., 12 (2): 538-48. [PMID:1740690]

2. Kramer, JW; Post, MA; Brown, AM; Kirsch, GE. (1998) Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 alpha-subunits. Am. J. Physiol., 274 (6 Pt 1): C1501-10. [PMID:9696692]

3. Salinas, M; Duprat, F; Heurteaux, C; Hugnot, JP; Lazdunski, M. (1997) New modulatory alpha subunits for mammalian Shab K+ channels. J. Biol. Chem., 272 (39): 24371-9. [PMID:9305895]

4. Su, K; Kyaw, H; Fan, P; Zeng, Z; Shell, BK; Carter, KC; Li, Y. (1997) Isolation, characterization, and mapping of two human potassium channels. Biochem. Biophys. Res. Commun., 241 (3): 675-81. [PMID:9434767]

5. Thorneloe, KS; Nelson, MT. (2003) Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current. J. Physiol. (Lond.), 549 (Pt 1): 65-74. [PMID:12679374]

6. Verma-Kurvari, S; Border, B; Joho, RH. (1997) Regional and cellular expression patterns of four K+ channel mRNAs in the adult rat brain. Brain Res. Mol. Brain Res., 46 (1-2): 54-62. [PMID:9191078]

To cite this database page, please use the following:

K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv5.1. Last modified on 01/07/2010. Accessed on 22/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=555.


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