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K2P1.1

Family: Two-P potassium channels

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
References
Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 1 336 1q42-43 KCNK1 potassium channel, subfamily K, member 1 1,3-4
Mouse 4 1 336 8 E2 Kcnk1 potassium channel, subfamily K, member 1 2
Rat 4 1 336 19q12 Kcnk1 potassium channel, subfamily K, member 1
Previous and Unofficial Names
KCNK1
TWIK-1
hOHO
K2P1.1
DPK
Twik
inward rectifying potassium channel protein TWIK-1
potassium channel subfamily K member 1
putative potassium channel TWIK
rTWIK
AI788889
Database Links
DrugBank Target 172 (Hs)
Ensembl ENSG00000135750 (Hs), ENSMUSG00000033998 (Mm), ENSRNOG00000019937 (Rn)
Entrez Gene 3775 (Hs), 16525 (Mm), 59324 (Rn)
GeneCards KCNK1 (Hs)
GenitoUrinary Development Molecular Anatomy Project Kcnk1 (Mm)
HomoloGene 1691 (Hs)
Human Protein Reference Database 03447 (Hs)
InterPro O00180 (Hs), O08581 (Mm), Q9Z2T2 (Rn)
KEGG Gene hsa:3775 (Hs), mmu:16525 (Mm), rno:59324 (Rn)
OMIM 601745 (Hs)
PharmGKB Gene PA219 (Hs)
PhosphoSitePlus O00180 (Hs), O08581 (Mm)
Protein Ontology (PRO) PRO:000002071 (Hs)
RefSeq Nucleotide NM_002245 (Hs), NM_008430 (Mm), NM_021688 (Rn)
RefSeq Protein NP_002236 (Hs), NP_032456 (Mm), NP_067720 (Rn)
TreeFam ENSG00000135750 (Hs), ENSMUSG00000033998 (Mm), ENSRNOG00000019937 (Rn)
UniGene Hs. 208544 (Hs)
UniProt O00180 (Hs), O08581 (Mm), Q9Z2T2 (Rn)
Wikipedia K2P1.1
Potassium channels
Search for 3D structures on the PDB
Search by keyword: Two-P potassium channels K2P1.1 Search by accession number: O00180, Q9Z2T2, O08581

REFERENCES

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1. Lesage, F; Guillemare, E; Fink, M; Duprat, F; Lazdunski, M; Romey, G; Barhanin, J. (1996) TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J., 15 (5): 1004-11. [PMID:8605869]

2. Lesage, F; Lauritzen, I; Duprat, F; Reyes, R; Fink, M; Heurteaux, C; Lazdunski, M. (1997) The structure, function and distribution of the mouse TWIK-1 K+ channel. FEBS Lett., 402 (1): 28-32. [PMID:9013852]

3. Lesage, F; Mattéi, M; Fink, M; Barhanin, J; Lazdunski, M. (1996) Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43. Genomics, 34 (1): 153-5. [PMID:8661042]

4. Orias, M; Velázquez, H; Tung, F; Lee, G; Desir, GV. (1997) Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments. Am. J. Physiol., 273 (4 Pt 2): F663-6. [PMID:9362344]

To cite this database page, please use the following:

Leigh Daniel Plant, Douglas A. Bayliss, Donghee Kim, Florian Lesage, Steve A.N. Goldstein.
Two-P potassium channels: K2P1.1. Last modified on 11/02/2011. Accessed on 25/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=513.


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