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GluA1

Family: Ionotropic glutamate receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Biologically Significant Variants
References
Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 3 1 906 5q31.1 GRIA1 glutamate receptor, ionotropic, AMPA 1 4-5,8
Mouse 3 1 907 11 B1.3 Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) 6
Rat 3 1 907 10 Gria1 glutamate receptor, ionotropic, AMPA 1 1-2,7
Previous and Unofficial Names
GLUA1
GluR1
GluRA
GluR-A
GluR-K1
HBGR1
GluR2
AMPA-selective glutamate receptor 1
gluR-1
glutamate receptor 1
glutamate receptor A
glutamate receptor subunit GluR1
glutamate receptor, ionotropic, AMPA 1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
Glr-1
Glr1
HIPA1
2900051M01Rik
AI853806
Database Links
ChEMBL Target 11114 (Hs), 11861 (Mm), 100001 (Rn)
DrugBank Target 705 (Hs)
Ensembl ENSG00000155511 (Hs), ENSMUSG00000020524 (Mm)
Entrez Gene 2890 (Hs), 14799 (Mm), 50592 (Rn)
GeneCards GRIA1 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gria1 (Mm)
HomoloGene 20226 (Hs)
Human Protein Reference Database 00695 (Hs)
InterPro P42261 (Hs), P23818 (Mm), P19490 (Rn)
KEGG Gene hsa:2890 (Hs), mmu:14799 (Mm), rno:50592 (Rn)
OMIM 138248 (Hs)
PharmGKB Gene PA28966 (Hs)
PhosphoSitePlus P42261 (Hs), P23818 (Mm), P19490 (Rn)
RefSeq Nucleotide NM_001114183 (Hs), NM_000827 (Hs), NM_008165 (Mm), NM_001113325 (Mm), NM_031608 (Rn)
RefSeq Protein NP_000818 (Hs), NP_001107655 (Hs), NP_032191 (Mm), NP_001106796 (Mm), NP_113796 (Rn)
TreeFam ENSG00000155511 (Hs), ENSMUSG00000020524 (Mm)
UniGene Hs. 519693 (Hs)
UniProt P42261 (Hs), P23818 (Mm), P19490 (Rn)
Ionotropic glutamate receptors
Search for 3D structures on the PDB
Search by keyword: Ionotropic glutamate receptors GluA1 Search by accession number: P23818, P19490, P42261
Natural/Endogenous Ligand(s)
glutamate
Biologically Significant Variants
‘flop’ isoform
Nucleotide accession:  NM_000827 
Protein accession:  NP_000818 
Type:  Splice variant.
Species:  Human
References:  4-5,8
‘flip’ isoform
Nucleotide accession:  NM_001114183 
Protein accession:  NP_001107655 
Type:  Splice variant.
Species:  Human
References:  3-5,8
‘flop’ isoform
Nucleotide accession:  NM_031608 
Protein accession:  NP_113796 
Type:  Splice variant.
Species:  Rat
References:  1-2,7
‘flip’ isoform
Nucleotide accession:  NM_001113325 
Protein accession:  NP_001106796 
Type:  Splice variant.
Species:  Mouse
References:  6
‘flop’ isoform
Nucleotide accession:  NM_008165 
Protein accession:  NP_032191 
Type:  Splice variant.
Species:  Mouse
References:  6
Biologically Significant Variant Comments
GluA1 exists as alternatively spliced ‘flip’ and ‘flop’ isoforms which differ with respect to a cassette of 35 amino acids in the extracellular loop between M3 and M4 [2] [7]. Tetrameric receptors assembled from the ‘flop’ isoform recover from desensitization at a slower rate than those formed from the ‘flip’ isoform, but have comparable rates of desensitization onset [3].

REFERENCES

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1. Hollmann, M; O'Shea-Greenfield, A; Rogers, SW; Heinemann, S. (1989) Cloning by functional expression of a member of the glutamate receptor family. Nature, 342 (6250): 643-8. [PMID:2480522]

2. Keinänen, K; Wisden, W; Sommer, B; Werner, P; Herb, A; Verdoorn, TA; Sakmann, B; Seeburg, PH. (1990) A family of AMPA-selective glutamate receptors. Science, 249 (4968): 556-60. [PMID:2166337]

3. Mosbacher, J; Schoepfer, R; Monyer, H; Burnashev, N; Seeburg, PH; Ruppersberg, JP. (1994) A molecular determinant for submillisecond desensitization in glutamate receptors. Science, 266 (5187): 1059-62. [PMID:7973663]

4. Potier, MC; Spillantini, MG; Carter, NP. (1992) The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. DNA Seq., 2 (4): 211-8. [PMID:1320959]

5. Puckett, C; Gomez, CM; Korenberg, JR; Tung, H; Meier, TJ; Chen, XN; Hood, L. (1991) Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. Proc. Natl. Acad. Sci. U.S.A., 88 (17): 7557-61. [PMID:1652753]

6. Sakimura, K; Bujo, H; Kushiya, E; Araki, K; Yamazaki, M; Yamazaki, M; Meguro, H; Warashina, A; Numa, S; Mishina, M. (1990) Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. FEBS Lett., 272 (1-2): 73-80. [PMID:1699805]

7. Sommer, B; Keinänen, K; Verdoorn, TA; Wisden, W; Burnashev, N; Herb, A; Köhler, M; Takagi, T; Sakmann, B; Seeburg, PH. (1990) Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science, 249 (4976): 1580-5. [PMID:1699275]

8. Sun, W; Ferrer-Montiel, AV; Schinder, AF; McPherson, JP; Evans, GA; Montal, M. (1992) Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. Proc. Natl. Acad. Sci. U.S.A., 89 (4): 1443-7. [PMID:1311100]

To cite this database page, please use the following:

John A. Peters, Stephane Peineau, Graham L Collingridge, Robert J. Wenthold.
Ionotropic glutamate receptors: GluA1. Last modified on 10/01/2012. Accessed on 24/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=444.


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