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Kir3.3

Family: Inwardly rectifying potassium channels

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Associated Proteins
Ion Selectivity and Conductance
Activators
Tissue Distribution
Physiological Functions
Phenotypes, Alleles and Disease Models
Clinically-Relevant Mutations and Pathophysiology
References
Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 1 393 1q21-23 KCNJ9 potassium inwardly-rectifying channel, subfamily J, member 9 5
Mouse 2 1 393 1 H3 Kcnj9 potassium inwardly-rectifying channel, subfamily J, member 9 4
Rat 2 1 393 13q24 Kcnj9 potassium inwardly-rectifying channel, subfamily J, member 9 1
Previous and Unofficial Names
GIRK3
Kir3.3
G protein-activated inward rectifier potassium channel 3
GIRK-3
inward rectifier K(+) channel Kir3.3
inwardly rectifier K(+) channel Kir3.3
potassium channel, inwardly rectifying subfamily J member 9
potassium inwardly-rectifying channel, subfamily J, member 9
1700085N21Rik
Database Links
Ensembl ENSG00000162728 (Hs), ENSMUSG00000038026 (Mm), ENSRNOG00000007645 (Rn)
Entrez Gene 3765 (Hs), 16524 (Mm), 116560 (Rn)
GeneCards KCNJ9 (Hs)
GenitoUrinary Development Molecular Anatomy Project Kcnj9 (Mm)
HomoloGene 37989 (Hs)
Human Protein Reference Database 02959 (Hs)
InterPro Q92806 (Hs), P48543 (Mm), Q63511 (Rn)
KEGG Gene hsa:3765 (Hs), mmu:16524 (Mm), rno:116560 (Rn)
OMIM 600932 (Hs)
PharmGKB Gene PA30051 (Hs)
PhosphoSitePlus Q92806 (Hs), P48543 (Mm), Q63511 (Rn)
Protein Ontology (PRO) PRO:000002004 (Hs)
RefSeq Nucleotide NM_004983 (Hs), NM_008429 (Mm), NM_053834 (Rn)
RefSeq Protein NP_004974 (Hs), NP_032455 (Mm), NP_446286 (Rn)
TreeFam ENSG00000162728 (Hs), ENSMUSG00000038026 (Mm), ENSRNOG00000007645 (Rn)
UniGene Hs. 66726 (Hs)
UniProt Q92806 (Hs), P48543 (Mm), Q63511 (Rn)
Wikipedia Kir3.3
Potassium channels
Search for 3D structures on the PDB
Search by keyword: Inwardly rectifying potassium channels Kir3.3 Search by accession number: Q63511, P48543, Q92806
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
Kir3.2 2
Kir3.1 3
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
Not determined
Ion Selectivity and Conductance
Species:  Mouse
Rank order:  K+
References:  2-3
Ion Selectivity and Conductance Comments
Kir3.3 forms functional heteromers with Kir3.2 (31pS, [2]) and Kir3.1 (39pS, [3]).
Activator Comments
Kir3.3 is activated by Gβγ subunits (pEC50 = 7.96 [3]).
Tissue Distribution
Pituitary, small intestine, testis, brain, fat, kidney, skeletal muscle, smooth muscle, pancreas.
Species:  Human
Technique:  RT-PCR
References:  6
Brain > skeletal muscle.
Species:  Mouse
Technique:  Northern Blot
References:  4
Brain (neocortex, olfactory system, hippocampus, thalamus > cerebellum, midbrain nuclei, brainstem nuclei, hypothalamus, amygdala, caudate putamen)
Species:  Rat
Technique:  In situ hybridisation
References:  1
Physiological Functions
Receptor-dependent hyperpolarisation of membrane potential.
Species:  None
Tissue: 
References:  1-3
Phenotypes, Alleles and Disease Models Mouse data from MGI

Click here to show/hide data

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Kcnj9tm1Kwn Kcnj9tm1Kwn/Kcnj9tm1Kwn
involves: 129X1/SvJ		 MGI:108007  MP:0003635 abnormal synaptic transmission PMID: 12040038 
Kcnj6tm1Stf|Kcnj9tm1Kwn Kcnj6tm1Stf/Kcnj6tm1Stf,Kcnj9tm1Kwn/Kcnj9tm1Kwn
involves: 129S1/Sv * 129X1/SvJ		 MGI:104781  MGI:108007  MP:0003635 abnormal synaptic transmission PMID: 12040038 
Kcnj6tm1Stf|Kcnj9tm1Kwn Kcnj6tm1Stf/Kcnj6tm1Stf,Kcnj9tm1Kwn/Kcnj9tm1Kwn
involves: 129S1/Sv * 129X1/SvJ		 MGI:104781  MGI:108007  MP:0002083 premature death PMID: 12040038 
Kcnj6tm1Stf|Kcnj9tm1Kwn Kcnj6tm1Stf/Kcnj6tm1Stf,Kcnj9tm1Kwn/Kcnj9tm1Kwn
involves: 129S1/Sv * 129X1/SvJ		 MGI:104781  MGI:108007  MP:0002064 seizures PMID: 12040038 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Candidate gene for type II diabetes mellitus.
OMIM:  125853
References:  6
Mutations not determined

REFERENCES

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1. Dissmann, E; Wischmeyer, E; Spauschus, A; Pfeil, DV; Karschin, C; Karschin, A. (1996) Functional expression and cellular mRNA localization of a G protein-activated K+ inward rectifier isolated from rat brain. Biochem. Biophys. Res. Commun., 223 (2): 474-9. [PMID:8670306]

2. Jelacic, TM; Kennedy, ME; Wickman, K; Clapham, DE. (2000) Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. J. Biol. Chem., 275 (46): 36211-6. [PMID:10956667]

3. Jelacic, TM; Sims, SM; Clapham, DE. (1999) Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3. J. Membr. Biol., 169 (2): 123-9. [PMID:10341034]

4. Lesage, F; Duprat, F; Fink, M; Guillemare, E; Coppola, T; Lazdunski, M; Hugnot, JP. (1994) Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. FEBS Lett., 353 (1): 37-42. [PMID:7926018]

5. Lesage, F; Fink, M; Barhanin, J; Lazdunski, M; Mattéi, MG. (1995) Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23. Genomics, 29 (3): 808-9. [PMID:8575783]

6. Vaughn, J; Wolford, JK; Prochazka, M; Permana, PA. (2000) Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3). Biochem. Biophys. Res. Commun., 274 (2): 302-9. [PMID:10913335]

To cite this database page, please use the following:

John P. Adelman, David E. Clapham, Hiroshi Hibino, Atsushi Inanobe, Lily Y. Jan, Andreas Karschin, Yoshihiro Kubo, Yoshihisa Kurachi, Michel Lazdunski, Takashi Miki, Colin G. Nichols, Wade L. Pearson, Susumu Seino, Carol A. Vandenberg.
Inwardly rectifying potassium channels: Kir3.3. Last modified on 01/07/2010. Accessed on 24/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=436.


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