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TAAR5

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Tissue Distribution
Expression Datasets
Biologically Significant Variants
References
Gene and Protein Information
class A G protein-coupled receptor: probable pseudogene
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 337 6q23 TAAR5 trace amine associated receptor 5 4
Mouse 7 337 10 A4 Taar5 trace amine-associated receptor 5
Rat 7 337 1p12 Taar5 trace amine-associated receptor 5
Previous and Unofficial Names
Putative neurotransmitter receptor
PNR
MGC138414
MGC138416
RP11-295F4.5
TAAR5
Trace amine receptor
Trace amine receptor 5
trace amine-associated receptor 5
TaR-5
trace amine associated receptor 5
LOC215854
Gm227
Database Links
Ensembl ENSG00000135569 (Hs), ENSMUSG00000069706 (Mm), ENSRNOG00000039869 (Rn)
Entrez Gene 9038 (Hs), 215854 (Mm), 294123 (Rn)
GeneCards TAAR5 (Hs)
GenitoUrinary Development Molecular Anatomy Project Taar5 (Mm)
HomoloGene 20850 (Hs)
Human Protein Reference Database 08459 (Hs)
InterPro O14804 (Hs), Q5QD14 (Mm), Q5QD23 (Rn)
KEGG Gene hsa:9038 (Hs), mmu:215854 (Mm), rno:294123 (Rn)
OMIM 607405 (Hs)
PharmGKB Gene PA142670843 (Hs)
PhosphoSitePlus O14804 (Hs), Q5QD14 (Mm), Q5QD23 (Rn)
Protein Ontology (PRO) PRO:000001679 (Hs)
RefSeq Nucleotide NM_003967 (Hs), NM_001009574 (Mm), NM_001009650 (Rn)
RefSeq Protein NP_003958 (Hs), NP_001009574 (Mm), NP_001009650 (Rn)
TreeFam ENSG00000135569 (Hs), ENSMUSG00000069706 (Mm), ENSRNOG00000039869 (Rn)
UniGene Hs. 248198 (Hs)
UniProt O14804 (Hs), Q5QD14 (Mm), Q5QD23 (Rn)
Wikipedia TAAR5
Orphan and other 7TM receptors
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
trimethylamine Mm Full agonist 6.52 pEC50 2
dimethylethylamine Mm Full agonist 6.15 pEC50 5
Agonist Comments
It is reported that mTAAR5 responded to N-methylpiperidine [2]. Staubert et al. show that the agonists of murine TAAR5 do not activate intact primate and mammalian orthologs [3].
Tissue Distribution
Skeletal muscle, amydgala, hippocampus, caudate nucleus, thalamus, hypothalamus, substantia nigra.
Species:  Human
Technique:  Northern blot
References:  4
Grueneberg ganglion (nasal septum, nasal cavity and nasal roof)
Species:  Mouse
Technique:  RT-PCR and in situ hybridisation
References:  1
Olfactory epithelium
Species:  Mouse
Technique:  RT-PCR
References:  2
Tissue Distribution Comments
No transcripts of TAAR5 were detected by Northern blot analysis in corpus callosum, subthalamic nucleus, lung, heart, pancreas, adult liver, lymph node, bone marrow, thymus, placenta, spleen and fetal liver [4].
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
R330C
SNP accession:  rs35839363 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
D131A, low frequency (<10% in tested population), but likely to be significant functionally as this is the D of the common DRY motif
SNP accession:  rs74571137 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
T272M, low frequency (<10% in tested population)
SNP accession:  rs34746740 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
Available Assays
DiscoveRx PathHunter® CHO-K1 TAAR5 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0718C2
DiscoveRx PathHunter® eXpress TAAR5 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0718E2CP1

REFERENCES

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1. Fleischer, J; Schwarzenbacher, K; Breer, H. (2007) Expression of trace amine-associated receptors in the Grueneberg ganglion. Chem. Senses, 32 (6): 623-31. [PMID:17556730]

2. Liberles, S. D. and Buck, L. B. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

3. Stäubert, C; Böselt, I; Bohnekamp, J; Römpler, H; Enard, W; Schöneberg, T. (2010) Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS ONE, 5 (6): e11133. [PMID:20559446]

4. Zeng, Z; Fan, P; Rand, E; Kyaw, H; Su, K; Madike, V; Carter, KC; Li, Y. (1998) Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain. Biochem. Biophys. Res. Commun., 242 (3): 575-8. [PMID:9464258]

5. Zucchi, R., Chiellini, G., Scanlan, T. S. and Grandy, D. K. (2006) Trace amine-associated receptors and their ligands. Br J Pharmacol, 149: 967-978. [PMID:17088868]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: TAAR5. Last modified on 16/01/2013. Accessed on 18/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=170.


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