image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing. 

TAAR4P

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Transduction Mechanisms
Expression Datasets
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor: probable pseudogene
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - 6q23.2 TAAR4P trace amine associated receptor 4, pseudogene
Mouse 7 347 10 A4 Taar4 trace amine-associated receptor 4
Rat 7 347 1p12 Taar4 trace amine-associated receptor 4
Previous and Unofficial Names
Ta2
taR-2
taR-4
trace amine receptor 2
trace amine receptor 4
trace amine-associated receptor 4
trace-amine-associated receptor 4
Gm226
Database Links
Ensembl ENSMUSG00000069707 (Mm), ENSRNOG00000029877 (Rn)
Entrez Gene 503612 (Hs), 209513 (Mm), 294122 (Rn)
GeneCards TAAR4P (Hs)
GenitoUrinary Development Molecular Anatomy Project Taar4 (Mm)
InterPro Q5QD15 (Mm), Q923Y7 (Rn)
KEGG Gene hsa:503612 (Hs), mmu:209513 (Mm), rno:294122 (Rn)
RefSeq Nucleotide NM_001008499 (Mm), NM_175583 (Rn)
RefSeq Protein NP_001008499 (Mm), NP_783173 (Rn)
TreeFam ENSMUSG00000069707 (Mm), ENSRNOG00000029877 (Rn)
UniProt Q5QD15 (Mm), Q923Y7 (Rn)
Wikipedia TAAR4P
Orphan and other 7TM receptors
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
β-phenylethylamine Rn Partial agonist - - 3
naphazoline Mm Agonist - - 3
naphazoline Rn Partial agonist - - 3
xylometazoline Mm Full agonist - - 3
β-phenylethylamine Mm Agonist 6.0 pEC50 1
View species-specific agonist tables
Agonist Comments
Agonist activity for β-phenylethylamine, naphazoline and xylometazoline was measured by CRE-SEAP reporter gene assay [3]. See the reference for agonist activity data plotted against SEAP activity.
Primary Transduction Mechanisms
Transducer Effector/Response
Gs family Adenylate cyclase stimulation
References:  3
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
General Comments
The compound β-phenylethylamine is elevated in urine in stress responses in rodents and humans, indicating a role for TAAR4 in stress and social cues [1-2].

REFERENCES

Show »

1. Liberles, S. D. and Buck, L. B. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

2. Maguire, JJ; Parker, WA; Foord, SM; Bonner, TI; Neubig, RR; Davenport, AP. (2009) International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. Pharmacol. Rev., 61 (1): 1-8. [PMID:19325074]

3. Stäubert, C; Böselt, I; Bohnekamp, J; Römpler, H; Enard, W; Schöneberg, T. (2010) Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS ONE, 5 (6): e11133. [PMID:20559446]

To cite this database page, please use the following:

Amy E. Monaghan.
Class A Orphans: TAAR4P . Last modified on 15/10/2012. Accessed on 20/06/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=169.


Contact us | Print | Back to top | Help