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TAAR3

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Tissue Distribution
Expression Datasets
References
Gene and Protein Information
class A G protein-coupled receptor: probable pseudogene
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 343 6q23-24 TAAR3 trace amine associated receptor 3 (gene/pseudogene) 1
Mouse 7 343 10 A4 Taar3 trace amine-associated receptor 3
Rat 7 342 1p12 Taar3 trace amine-associated receptor 3
Previous and Unofficial Names
trace amine associated receptor 3
GPR57
G protein-coupled receptor 57
taR-3
trace amine receptor 3
trace amine-associated receptor 3
Database Links
Ensembl ENSG00000179073 (Hs), ENSMUSG00000069708 (Mm), ENSRNOG00000025982 (Rn)
Entrez Gene 9288 (Hs), 493809 (Mm), 494319 (Rn)
GeneCards TAAR3 (Hs)
GenitoUrinary Development Molecular Anatomy Project Taar3 (Mm)
HomoloGene 79458 (Hs)
InterPro Q9P1P4 (Hs), Q5QD16 (Mm), Q5QD24 (Rn)
KEGG Gene hsa:9288 (Hs), mmu:493809 (Mm), rno:494319 (Rn)
PharmGKB Gene PA28902 (Hs)
PhosphoSitePlus Q9P1P4 (Hs), Q5QD16 (Mm), Q5QD24 (Rn)
Protein Ontology (PRO) PRO:000001713 (Hs)
RefSeq Nucleotide NM_003967 (Hs), NM_001008429 (Mm), NM_001009532 (Rn)
RefSeq Protein NP_001008429 (Mm), NP_001009532 (Rn)
TreeFam ENSG00000179073 (Hs), ENSMUSG00000069708 (Mm), ENSRNOG00000025982 (Rn)
UniGene Hs. 679662 (Hs)
UniProt Q9P1P4 (Hs), Q5QD16 (Mm), Q5QD24 (Rn)
Wikipedia TAAR3
Orphan and other 7TM receptors
Natural/Endogenous Ligand(s)
Comments: probable pseudogene.
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
isoamylamine Mm Full agonist 5.0 pEC50 2
Agonist Comments
Cyclohexylamine has been shown to be an agonist at this receptor in mice [2]. It has been shown that the agonists of murine TAAR3 do not activate intact primate and mammalian orthologs [3].
Tissue Distribution
Olfactory epithelium
Species:  Mouse
Technique:  In situ hybridisation and RT-PCR.
References:  2
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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REFERENCES

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1. Lee, DK; Lynch, KR; Nguyen, T; Im, DS; Cheng, R; Saldivia, VR; Liu, Y; Liu, IS; Heng, HH; Seeman, P; George, SR; O'Dowd, BF; Marchese, A. (2000) Cloning and characterization of additional members of the G protein-coupled receptor family. Biochim. Biophys. Acta, 1490 (3): 311-23. [PMID:10684976]

2. Liberles, S. D. and Buck, L. B. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

3. Stäubert, C; Böselt, I; Bohnekamp, J; Römpler, H; Enard, W; Schöneberg, T. (2010) Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS ONE, 5 (6): e11133. [PMID:20559446]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: TAAR3. Last modified on 25/07/2012. Accessed on 21/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=168.


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