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TAAR2

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Transduction Mechanisms
Tissue Distribution
Expression Datasets
Clinically-Relevant Mutations and Pathophysiology
Biologically Significant Variants
References
Gene and Protein Information
class A G protein-coupled receptor: probable pseudogene
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 351 6q23.2 TAAR2 trace amine associated receptor 2 5
Mouse 7 339 10 A4 Taar2 trace amine-associated receptor 2
Rat 7 339 1p12 Taar2 trace amine-associated receptor 2
Previous and Unofficial Names
GPR58
TA2
trace amine associated receptor 2
TAA2
G protein-coupled receptor 58
Gpr58_predicted
LOC294121
Taar2
G protein-coupled receptor 58 (predicted)
G-protein coupled receptor 58
taR-2
trace amine receptor 2
trace amine-associated receptor 2
Gm225
Database Links
Ensembl ENSG00000146378 (Hs), ENSMUSG00000059763 (Mm), ENSRNOG00000025951 (Rn)
Entrez Gene 9287 (Hs), 209512 (Mm), 294121 (Rn)
GeneCards TAAR2 (Hs)
GenitoUrinary Development Molecular Anatomy Project Taar2 (Mm)
HomoloGene 75029 (Hs)
Human Protein Reference Database 06887 (Hs)
InterPro Q9P1P5 (Hs), Q5QD17 (Mm), Q5QD25 (Rn)
KEGG Gene hsa:9287 (Hs), mmu:209512 (Mm), rno:294121 (Rn)
OMIM 604849 (Hs)
PharmGKB Gene PA28903 (Hs)
PhosphoSitePlus Q9P1P5 (Hs), Q5QD17 (Mm), Q5QD25 (Rn)
Protein Ontology (PRO) PRO:000001712 (Hs)
RefSeq Nucleotide NM_001033080 (Hs), NM_001007266 (Mm), NM_001008512 (Rn)
RefSeq Protein NP_001028252 (Hs), NP_001007267 (Mm), NP_001008512 (Rn)
TreeFam ENSG00000146378 (Hs), ENSMUSG00000059763 (Mm), ENSRNOG00000025951 (Rn)
UniGene Hs. 272382 (Hs)
UniProt Q9P1P5 (Hs), Q5QD17 (Mm), Q5QD25 (Rn)
Wikipedia TAAR2
Orphan and other 7TM receptors
Rank order of potency
β-phenylethylamine > tryptamine  [2]
Primary Transduction Mechanisms
Comments:  TAAR2 is found to be coexpressed with Gα proteins. However, the transduction pathway of TAAR2 is yet to be determined.
References:  6
Tissue Distribution
Cells of Grueneberg ganglion
Species:  Mouse
Technique:  in situ hybridisation
References:  3
Olfactory epithelium
Species:  Mouse
Technique:  RT-PCR and in situ hybridisation.
References:  6
Mucosal layer of gastrointestinal tract, predominantly in duodenum.
Species:  Mouse
Technique:  RT-PCR
References:  4
Heart
Species:  Rat
Technique: 
References:  7
Tissue Distribution Comments
No TAAR2 mRNAs were detected by Northern blot analysis in the pons, thalamus, hypothalamus, hippocampus, caudate, putamen, frontal cortex, basal forebrain, midbrain and liver [5].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Clinically-Relevant Mutations and Pathophysiology
Role:  A SNP nonsense mutation in the TAAR2 gene has been associated with schizophrenia.
References:  1
Mutations not determined
Biologically Significant Variants
R43Q
SNP accession:  rs73775147 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
S130F
SNP accession:  rs61731216 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
G60C, low frequency (<10% in tested population)
SNP accession:  rs61731216 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
W168Ter found in 10-15% of Asian population
SNP accession:  rs8192646 
Type:  Naturally occurring SNPs.
Species:  Human
References: 

REFERENCES

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1. Bly, M. (2005) Examination of the trace amine-associated receptor 2 (TAAR2). Schizophr. Res., 80 (2-3): 367-8. [PMID:15993565]

2. Borowsky, B., Adham, N., Jones, K. A., Raddatz, R., Artymyshyn, R., Ogozalek, K. L., Durkin, M. M., Lakhlani, P. P., Bonini, J. A., Pathirana, S., Boyle, N., Pu, X., Kouranova, E., Lichtblau, H., Ochoa, F. Y., Branchek, T. A. and Gerald, C. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci U S A, 98: 8966-8971. [PMID:11459929]

3. Fleischer, J; Schwarzenbacher, K; Breer, H. (2007) Expression of trace amine-associated receptors in the Grueneberg ganglion. Chem. Senses, 32 (6): 623-31. [PMID:17556730]

4. Ito, J; Ito, M; Nambu, H; Fujikawa, T; Tanaka, K; Iwaasa, H; Tokita, S. (2009) Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice. Cell Tissue Res., 338 (2): 257-69. [PMID:19763624]

5. Lee, DK; Lynch, KR; Nguyen, T; Im, DS; Cheng, R; Saldivia, VR; Liu, Y; Liu, IS; Heng, HH; Seeman, P; George, SR; O'Dowd, BF; Marchese, A. (2000) Cloning and characterization of additional members of the G protein-coupled receptor family. Biochim. Biophys. Acta, 1490 (3): 311-23. [PMID:10684976]

6. Liberles, S. D. and Buck, L. B. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

7. Zucchi, R., Chiellini, G., Scanlan, T. S. and Grandy, D. K. (2006) Trace amine-associated receptors and their ligands. Br J Pharmacol, 149: 967-978. [PMID:17088868]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: TAAR2. Last modified on 05/11/2012. Accessed on 26/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=167.


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