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P2RY10

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Antagonists
Tissue Distribution
Expression Datasets
Biologically Significant Variants
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 339 Xq21.1 P2RY10 purinergic receptor P2Y, G-protein coupled, 10
Mouse 7 328 X D P2ry10 purinergic receptor P2Y, G-protein coupled 10
Rat 7 388 Xq31 P2ry10 purinergic receptor P2Y, G-protein coupled, 10
Previous and Unofficial Names
purinergic receptor P2Y, G-protein coupled, 10
P2Y-like receptor
P2Y10
purinergic receptor
P2Y-like
LOC317219
MGC189289
P2ry10_predicted
RGD1561912
RGD1561912_predicted
purinergic receptor P2Y, G-protein coupled 10
purinergic receptor P2Y, G-protein coupled 10 (predicted)
similar to purinergic receptor P2Y, G-protein coupled 10
similar to purinergic receptor P2Y, G-protein coupled 10 (predicted)
5830408N17Rik
Database Links
Ensembl ENSG00000078589 (Hs), ENSMUSG00000050921 (Mm), ENSRNOG00000037839 (Rn)
Entrez Gene 27334 (Hs), 78826 (Mm), 317219 (Rn)
GeneCards P2RY10 (Hs)
GenitoUrinary Development Molecular Anatomy Project P2ry10 (Mm)
HomoloGene 8717 (Hs)
Human Protein Reference Database 06670 (Hs)
InterPro O00398 (Hs), Q7TMT1 (Mm)
KEGG Gene hsa:27334 (Hs), mmu:78826 (Mm), rno:317219 (Rn)
OMIM 300529 (Hs)
PharmGKB Gene PA134873055 (Hs)
PhosphoSitePlus O00398 (Hs), Q8BFU7 (Mm)
Protein Ontology (PRO) PRO:000001652 (Hs)
RefSeq Nucleotide NM_014499 (Hs), NM_172435 (Mm), NM_001177682 (Rn)
RefSeq Protein NP_055314 (Hs), NP_766023 (Mm), NP_001171153 (Rn)
TreeFam ENSG00000078589 (Hs), ENSMUSG00000050921 (Mm), ENSRNOG00000037839 (Rn)
UniGene Hs. 296433 (Hs)
UniProt O00398 (Hs), Q7TMT1 (Mm)
Wikipedia P2RY10
Orphan and other 7TM receptors
Natural/Endogenous Ligand(s)
LPA
sphingosine 1-phosphate
Comments: Proposed ligands, single publication
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
sphingosine 1-phosphate Hs Agonist 7.3 pEC50 2
LPA Hs Agonist 6.9 pEC50 2
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
dioctanoy​lglycerol​ pyrophos​phate Hs Antagonist - - 2
JTE-013 Hs Antagonist - - 2
Tissue Distribution
Platelets
Expression level:  High
Species:  Human
Technique:  Q-RT-PCR (Microarray analysis) and Western Blotting
References:  1
placenta, uterus, prostate, brain, lung, and skeletal muscle
Expression level:  High
Species:  Mouse
Technique:  RT-PCR
References:  2
B-cells
Expression level:  High
Species:  Mouse
Technique:  Northern blot, subtractive hybridisation
References:  3
Tissue Distribution Comments
RT-PCR analyses with mouse tissues demonstrated that the P2Y10 gene was expressed in uterus, prostate, brain, lung and skeletal muscle, but not in testis, liver, or kidney, [2].
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
N3H
SNP accession:  rs6618868 
Type:  Naturally occurring SNPs.
Species:  Human
References: 

REFERENCES

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1. Amisten, S; Braun, OO; Bengtsson, A; Erlinge, D. (2008) Gene expression profiling for the identification of G-protein coupled receptors in human platelets. Thromb. Res., 122 (1): 47-57. [PMID:17920662]

2. Murakami, M; Shiraishi, A; Tabata, K; Fujita, N. (2008) Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem. Biophys. Res. Commun., 371 (4): 707-12. [PMID:18466763]

3. Rao, S; Garrett-Sinha, LA; Yoon, J; Simon, MC. (1999) The Ets factors PU.1 and Spi-B regulate the transcription in vivo of P2Y10, a lymphoid restricted heptahelical receptor. J. Biol. Chem., 274 (48): 34245-52. [PMID:10567398]

To cite this database page, please use the following:

Chido Mpamhanga.
Class A Orphans: P2RY10. Last modified on 05/11/2012. Accessed on 24/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=165.


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