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OPN5

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Transduction Mechanisms
Tissue Distribution
Expression Datasets
Clinically-Relevant Mutations and Pathophysiology
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 354 6p12.3 OPN5 opsin 5 1,7
Mouse 7 377 17 B3 Opn5 opsin 5 1,7
Rat 7 534 9q12 Opn5 opsin 5
Previous and Unofficial Names
opsin 5
transmembrane protein 13
neuropsin
dJ402H5.1
GPR136
PGR12
OPN5
PGR14
G-protein coupled receptor 136
Transmembrane protein 13
Neuropsin
opsin-5
G-protein coupled receptor PGR12
TMEM13
G protein-coupled receptor 136
Database Links
Ensembl ENSG00000124818 (Hs), ENSMUSG00000043972 (Mm), ENSRNOG00000012689 (Rn)
Entrez Gene 221391 (Hs), 353344 (Mm), 316259 (Rn)
GeneCards OPN5 (Hs)
GenitoUrinary Development Molecular Anatomy Project Opn5 (Mm)
HomoloGene 72341 (Hs)
Human Protein Reference Database 12358 (Hs)
InterPro Q6U736 (Hs), Q6VZZ7 (Mm), Q7TQN6 (Rn)
KEGG Gene hsa:221391 (Hs), mmu:353344 (Mm), rno:316259 (Rn)
OMIM 609042 (Hs)
PharmGKB Gene PA134942887 (Hs)
PhosphoSitePlus Q6U736 (Hs), Q6VZZ7 (Mm)
Protein Ontology (PRO) PRO:000001180 (Hs)
RefSeq Nucleotide NM_181744 (Hs), NM_181753 (Mm), NM_181772 (Rn)
RefSeq Protein NP_859528 (Hs), NP_861418 (Mm), NP_861437 (Rn)
TreeFam ENSG00000124818 (Hs), ENSMUSG00000043972 (Mm), ENSRNOG00000012689 (Rn)
UniGene Hs. 213717 (Hs)
UniProt Q6U736 (Hs), Q6VZZ7 (Mm), Q7TQN6 (Rn)
Wikipedia OPN5
Orphan and other 7TM receptors
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family
Comments:  Evidence indicates OPN5 triggers a UV-sensitive Gi-mediated signalling pathway in mammalian tissues [4].
References:  4
Tissue Distribution
Retina, brain, testis
Species:  Human
Technique:  RT-PCR
References:  7
Eye, brain, testis
Species:  Mouse
Technique:  RT-PCR
References:  7
Retina (non-rod non-cone retinal neurons), brain, outer ears (epidermal and muscle cells)
Species:  Mouse
Technique:  Immunohistochemistry
References:  4
Retina (inner plexiform layer, inner nuclear layer)
Species:  Rat
Technique:  Immunohistochemistry
References:  6
Tissue Distribution Comments
The human Müller cell line MIO-M1 expresses OPN5 [2].
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Clinically-Relevant Mutations and Pathophysiology Comments
Association studies suggested that genetic variation of OPN5 may contribute to the molecular mechanisms of bipolar disorder, and some aspects of memory and intelligence [3].
General Comments
OPN5 has been identified as a deep brain photoreceptor in birds [5]. Human and mouse OPN5 have a maximum UV absorption at 380nm, indicating that the receptor is the first human opsin with a peak sensitivity in the UV region [4].
Available Assays
DiscoveRx PathHunter® CHO-K1 OPN5 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0704C2
DiscoveRx PathHunter® eXpress OPN5 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0704E2CP1

REFERENCES

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1. Fornai, F; Lenzi, P; Gesi, M; Ferrucci, M; Lazzeri, G; Busceti, CL; Ruffoli, R; Soldani, P; Ruggieri, S; Alessandri, MG; et al.. (2003) Fine structure and biochemical mechanisms underlying nigrostriatal inclusions and cell death after proteasome inhibition. J. Neurosci., 23 (26): 8955-66. [PMID:14523098]

2. Hollborn, M; Ulbricht, E; Rillich, K; Dukic-Stefanovic, S; Wurm, A; Wagner, L; Reichenbach, A; Wiedemann, P; Limb, GA; Bringmann, A; et al.. (2011) The human Müller cell line MIO-M1 expresses opsins. Mol. Vis., 17: 2738-50. [PMID:22065927]

3. Izumi, A; Iijima, Y; Noguchi, H; Numakawa, T; Okada, T; Hori, H; Kato, T; Tatsumi, M; Kosuga, A; Kamijima, K; et al.. (2008) Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions. Neuropsychopharmacology, 33 (13): 3237-45. [PMID:18354391]

4. Kojima, D; Mori, S; Torii, M; Wada, A; Morishita, R; Fukada, Y. (2011) UV-sensitive photoreceptor protein OPN5 in humans and mice. PLoS ONE, 6 (10): e26388. [PMID:22043319]

5. Nakane, Y; Ikegami, K; Ono, H; Yamamoto, N; Yoshida, S; Hirunagi, K; Ebihara, S; Kubo, Y; Yoshimura, T. (2010) A mammalian neural tissue opsin (Opsin 5) is a deep brain photoreceptor in birds. Proc. Natl. Acad. Sci. U.S.A., 107 (34): 15264-8. [PMID:20679218]

6. Nieto, PS; Valdez, DJ; Acosta-Rodríguez, VA; Guido, ME. (2011) Expression of novel opsins and intrinsic light responses in the mammalian retinal ganglion cell line RGC-5. Presence of OPN5 in the rat retina. PLoS ONE, 6 (10): e26417. [PMID:22022612]

7. Tarttelin, EE; Bellingham, J; Hankins, MW; Foster, RG; Lucas, RJ. (2003) Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. FEBS Lett., 554 (3): 410-6. [PMID:14623103]

To cite this database page, please use the following:

Amy E. Monaghan.
Class A Orphans: OPN5. Last modified on 31/10/2012. Accessed on 24/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=161.


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