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MRGPRX3

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Transduction Mechanisms
Biologically Significant Variants
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 322 11p15.1 MRGPRX3 MAS-related GPR, member X3
Structural Information Comments
Mrgprx3 is a pseudogene in mouse
Previous and Unofficial Names
MrgA
Mrgpra
MRGX3
Mrga10
SNSR1
SNSR2
Sensory neuron-specific G protein-coupled receptor 1/2
MAS-related GPR, member X3
Database Links
Ensembl
Entrez Gene
GeneCards
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProt
Wikipedia
Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
References:  2
Biologically Significant Variants
N169D
SNP accession:  rs4274188 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
C82R
SNP accession:  rs12291017 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
General Comments
Of the eight human Mas-related GPCRs (MRGs), four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) have clear orthologues in rodents, whereas the cluster of genes including human MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 is found only in primates and is replaced in rodents with a family of genes (>25 in mice, ~10 in rats) which have no obvious human counterparts [3]. Certain rodent MRGs have been reported to respond to adenine [1] and to RF-amide peptides including neuropeptide FF [4-5] but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [6-7].

REFERENCES

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: MRGPRX3. Last modified on 05/11/2012. Accessed on 20/06/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=158.


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