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GPR174

Family: Class A Orphans

This receptor has a proposed ligand; see the Latest Pairings page for more information.

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Expression Datasets
Gene Expression and Pathophysiology
Biologically Significant Variants
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 333 Xq13.3 GPR174 G protein-coupled receptor 174
Mouse 7 335 X D Gpr174 G protein-coupled receptor 174
Rat 7 335 Xq31 Gpr174 G protein-coupled receptor 174
Previous and Unofficial Names
FKSG79
RGD1564689
Gpr174_predicted
LOC302373
RGD1564689_predicted
G protein-coupled receptor 174
G protein-coupled receptor 174 (predicted)
probable G-protein coupled receptor 174
similar to putative purinergic receptor FKSG79
similar to putative purinergic receptor FKSG79 (predicted)
LOC213439
Gm376
Database Links
Ensembl ENSG00000147138 (Hs), ENSMUSG00000073008 (Mm), ENSRNOG00000032970 (Rn)
Entrez Gene 84636 (Hs), 213439 (Mm), 302373 (Rn)
GeneCards GPR174 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr174 (Mm)
HomoloGene 13059 (Hs)
Human Protein Reference Database 06512 (Hs)
InterPro Q9BXC1 (Hs), Q3U507 (Mm)
KEGG Gene hsa:84636 (Hs), mmu:213439 (Mm), rno:302373 (Rn)
PharmGKB Gene PA134971573 (Hs)
PhosphoSitePlus Q9BXC1 (Hs), Q3U507 (Mm)
Protein Ontology (PRO) PRO:000001640 (Hs)
RefSeq Nucleotide NM_032553 (Hs), NM_001033251 (Mm), NM_001106938 (Rn)
RefSeq Protein NP_115942 (Hs), NP_001028423 (Mm), NP_001100408 (Rn)
TreeFam ENSG00000147138 (Hs), ENSMUSG00000073008 (Mm), ENSRNOG00000032970 (Rn)
UniGene Hs. 326713 (Hs)
UniProt Q9BXC1 (Hs), Q3U507 (Mm)
Wikipedia GPR174
Orphan and other 7TM receptors
Agonist Comments
GPR174 has been shown to be activated by lysophosphatidylserine [1,3].
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Gene Expression and Pathophysiology Comments
GPR174 is found to be overexpressed in subcutaneous metastases [2].
Biologically Significant Variants
S162P
SNP accession:  rs3827440 
Type:  Naturally occurring SNPs.
Species:  Human
References: 

REFERENCES

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1. Inoue, A; Ishiguro, J; Kitamura, H; Arima, N; Okutani, M; Shuto, A; Higashiyama, S; Ohwada, T; Arai, H; Makide, K; et al.. (2012) TGFα shedding assay: an accurate and versatile method for detecting GPCR activation. Nat. Methods, 9 (10): 1021-9. [PMID:22983457]

2. Qin, Y; Verdegaal, EM; Siderius, M; Bebelman, JP; Smit, MJ; Leurs, R; Willemze, R; Tensen, CP; Osanto, S. (2010) Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target. Pigment Cell Melanoma Res,  [Epub ahead of print]. [PMID:20880198]

3. Sugita, K; Yamamura, C; Tabata, K; Fujita, N. (2013) Expression of orphan G-protein coupled receptor GPR174 in CHO cells induced morphological changes and proliferation delay via increasing intracellular cAMP. Biochem. Biophys. Res. Commun., 430 (1): 190-5. [PMID:23178570]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: GPR174. Last modified on 07/03/2013. Accessed on 20/06/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=145.


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