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GPR173

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Tissue Distribution
Expression Datasets
Gene Expression and Pathophysiology
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 373 Xp11 GPR173 G protein-coupled receptor 173
Mouse 7 373 X F2 Gpr173 G-protein coupled receptor 173
Rat 7 373 Xq21 Gpr173 G-protein coupled receptor 173
Previous and Unofficial Names
SREB3
Super conserved receptor expressed in brain 3
GPR173
G-protein coupled receptor 173
probable G-protein coupled receptor 173
G protein coupled receptor 173
3230401K02Rik
Database Links
Ensembl ENSG00000184194 (Hs), ENSMUSG00000056679 (Mm), ENSRNOG00000003272 (Rn)
Entrez Gene 54328 (Hs), 70771 (Mm), 64021 (Rn)
GeneCards GPR173 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr173 (Mm)
HomoloGene 10354 (Hs)
Human Protein Reference Database 02220 (Hs)
InterPro Q9NS66 (Hs), Q6PI62 (Mm), Q9JJH2 (Rn)
KEGG Gene hsa:54328 (Hs), mmu:70771 (Mm), rno:64021 (Rn)
OMIM 300253 (Hs)
PharmGKB Gene PA134896710 (Hs)
PhosphoSitePlus Q9NS66 (Hs), Q6PI62 (Mm), Q9JJH2 (Rn)
Protein Ontology (PRO) PRO:000001639 (Hs)
RefSeq Nucleotide NM_018969 (Hs), NM_027543 (Mm), NM_022255 (Rn)
RefSeq Protein NP_061842 (Hs), NP_081819 (Mm), NP_071591 (Rn)
TreeFam ENSG00000184194 (Hs), ENSMUSG00000056679 (Mm), ENSRNOG00000003272 (Rn)
UniGene Hs. 661815 (Hs)
UniProt Q9NS66 (Hs), Q6PI62 (Mm), Q9JJH2 (Rn)
Wikipedia GPR173
Orphan and other 7TM receptors
Tissue Distribution
Brain, ovary, small intestine
Species:  Human
Technique:  Northern blot
References:  2
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Gene Expression and Pathophysiology Comments
GPR173 was coexpressed with GPER, PTHR1 and SSTR1 in liver depression and spleen deficiency syndrome (LDSDS) [1].
General Comments
GPR173 belongs to the SREB (Super conserved Receptor Expressed in Brain) family of GPCRs [2].
Available Assays
DiscoveRx PathHunter® HEK 293 GPR173 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0380C1A
DiscoveRx PathHunter® CHO-K1 GPR173 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0380C2A
DiscoveRx PathHunter® eXpress GPR173 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0380E2ACP1

REFERENCES

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1. Guo, Z; Yu, S; Guan, Y; Li, YY; Lu, YY; Zhang, H; Su, SB. (2012) Molecular Mechanisms of Same TCM Syndrome for Different Diseases and Different TCM Syndrome for Same Disease in Chronic Hepatitis B and Liver Cirrhosis. Evid Based Complement Alternat Med, 2012: 120350. [PMID:22693527]

2. Matsumoto, M; Saito, T; Takasaki, J; Kamohara, M; Sugimoto, T; Kobayashi, M; Tadokoro, M; Matsumoto, S; Ohishi, T; Furuichi, K. (2000) An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Biochem. Biophys. Res. Commun., 272 (2): 576-82. [PMID:10833454]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: GPR173. Last modified on 01/08/2012. Accessed on 19/06/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=144.


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