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GPR171

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Expression Datasets
Biologically Significant Variants
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 319 3q25.1 GPR171 G protein-coupled receptor 171 1
Mouse 7 319 3 D Gpr171 G protein-coupled receptor 171
Rat 7 326 2q31 Gpr171 G protein-coupled receptor 171
Previous and Unofficial Names
H963
F730001G15Rik
GPR171
G-protein coupled receptor 171
G protein-coupled receptor 171
G-protein coupled receptor H963
platelet activating receptor homolog
probable G-protein coupled receptor 171
LOC688737
similar to G protein-coupled receptor 171
Database Links
Ensembl ENSG00000174946 (Hs), ENSMUSG00000050075 (Mm), ENSRNOG00000025297 (Rn)
Entrez Gene 29909 (Hs), 229323 (Mm), 688737 (Rn)
GeneCards GPR171 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr171 (Mm)
HomoloGene 36330 (Hs)
Human Protein Reference Database 17071 (Hs)
InterPro O14626 (Hs), Q8CIF3 (Mm)
KEGG Gene hsa:29909 (Hs), mmu:229323 (Mm), rno:688737 (Rn)
PharmGKB Gene PA134948560 (Hs)
PhosphoSitePlus O14626 (Hs), Q8BG55 (Mm)
Protein Ontology (PRO) PRO:000001518 (Hs)
RefSeq Nucleotide NM_013308 (Hs), NM_173398 (Mm), NM_001109510 (Rn)
RefSeq Protein NP_013308 (Hs), NP_775574 (Mm), NP_001102980 (Rn)
TreeFam ENSG00000174946 (Hs), ENSMUSG00000050075 (Mm), ENSRNOG00000025297 (Rn)
UniGene Hs. 549152 (Hs)
UniProt O14626 (Hs), Q8CIF3 (Mm)
Wikipedia GPR171
Orphan and other 7TM receptors
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
A35S
SNP accession:  s77381566 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
I285V
SNP accession:  rs3732756 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
Q88K
SNP accession:  rs77205427 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
General Comments
GPR171 is excluded as a candidate gene of Usher syndrome Type 3 [2].
Available Assays
DiscoveRx PathHunter® CHO-K1 GPR171 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0415C2A
DiscoveRx PathHunter® eXpress GPR171 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0415E2ACP1

REFERENCES

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1. Jacobs, KA; Collins-Racie, LA; Colbert, M; Duckett, M; Golden-Fleet, M; Kelleher, K; Kriz, R; LaVallie, ER; Merberg, D; Spaulding, V; et al.. (1997) A genetic selection for isolating cDNAs encoding secreted proteins. Gene, 198 (1-2): 289-96. [PMID:9370294]

2. Joensuu, T; Hämäläinen, R; Yuan, B; Johnson, C; Tegelberg, S; Gasparini, P; Zelante, L; Pirvola, U; Pakarinen, L; Lehesjoki, AE; et al.. (2001) Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. Am. J. Hum. Genet., 69 (4): 673-84. [PMID:11524702]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: GPR171. Last modified on 05/11/2012. Accessed on 24/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=143.


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