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GPR160

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Expression Datasets
Functional Assays
Clinically-Relevant Mutations and Pathophysiology
Biologically Significant Variants
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 338 3q26.2-q27 GPR160 G protein-coupled receptor 160
Mouse 7 336 3 B Gpr160 G protein-coupled receptor 160
Rat 7 336 2q24 Gpr160 G protein-coupled receptor 160
Previous and Unofficial Names
GPCR150
GPCR1
G protein-coupled receptor 160
probable G-protein coupled receptor 160
1700025D19Rik
Database Links
Ensembl ENSG00000173890 (Hs), ENSMUSG00000037661 (Mm), ENSRNOG00000009487 (Rn)
Entrez Gene 26996 (Hs), 71862 (Mm), 499588 (Rn)
GeneCards GPR160 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr160 (Mm)
HomoloGene 8659 (Hs)
Human Protein Reference Database 17069 (Hs)
InterPro Q9UJ42 (Hs), Q3U3F9 (Mm), Q66H29 (Rn)
KEGG Gene hsa:26996 (Hs), mmu:71862 (Mm), rno:499588 (Rn)
PharmGKB Gene PA134936972 (Hs)
PhosphoSitePlus Q9UJ42 (Hs), Q3U3F9 (Mm), Q66H29 (Rn)
Protein Ontology (PRO) PRO:000001516 (Hs)
RefSeq Nucleotide NM_014373 (Hs), NM_001134385 (Mm), NM_001025147 (Rn)
RefSeq Protein NP_055188 (Hs), NP_001127857 (Mm), NP_001020318 (Rn)
TreeFam ENSG00000173890 (Hs), ENSMUSG00000037661 (Mm), ENSRNOG00000009487 (Rn)
UniGene Hs. 231320 (Hs)
UniProt Q9UJ42 (Hs), Q3U3F9 (Mm), Q66H29 (Rn)
Wikipedia GPR160
Orphan and other 7TM receptors
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
miR-125b negatively regulates GPR160 expression in lymphoblastoid cell lines
Species:  Human
Tissue:  Lymphoblastoid cell line
Response measured:  Decreased expression
References:  2
Clinically-Relevant Mutations and Pathophysiology
Disease:  Nasopharangeal carcinoma
Comments:  Increased gene expression seen in nasopharangeal carcinoma identified by combined microarray and FISH analysis.
References:  3
Mutations not determined
Disease:  Metastatic melanoma
Comments:  Receptor overexpression observed in melanoma metastases.
References:  4
Mutations not determined
Disease:  Prostate cancer
Comments:  Gene associated with prostate cancer identified by microarray analysis.
References:  1,3
Mutations not determined
Biologically Significant Variants
L108F, low frequency (<10% in all tested populations)
SNP accession:  rs78780869 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
V65I, low frequency (<10% in all tested populations)
SNP accession:  rs61745703 
Type:  Naturally occurring SNPs.
Species:  Human
References: 

REFERENCES

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1. Dijkman, R; van Doorn, R; Szuhai, K; Willemze, R; Vermeer, MH; Tensen, CP. (2007) Gene-expression profiling and array-based CGH classify CD4+CD56+ hematodermic neoplasm and cutaneous myelomonocytic leukemia as distinct disease entities. Blood, 109 (4): 1720-7. [PMID:17068154]

2. Lee, JE; Hong, EJ; Nam, HY; Kim, JW; Han, BG; Jeon, JP. (2011) MicroRNA signatures associated with immortalization of EBV-transformed lymphoblastoid cell lines and their clinical traits. Cell Prolif., 44 (1): 59-66. [PMID:21199010]

3. Mudipalli, A; Owen, RD; Preston, RJ. (2005) The effect of arsenicals on ultraviolet-radiation-induced growth arrest and related signaling events in human keratinocytes. Int. J. Oncol., 27 (3): 769-78. [PMID:16077927]

4. Qin, Y; Verdegaal, EM; Siderius, M; Bebelman, JP; Smit, MJ; Leurs, R; Willemze, R; Tensen, CP; Osanto, S. (2010) Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target. Pigment Cell Melanoma Res,  [Epub ahead of print]. [PMID:20880198]

To cite this database page, please use the following:

Amy E. Monaghan.
Class A Orphans: GPR160. Last modified on 05/11/2012. Accessed on 19/06/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=140.


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