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GPR151

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Tissue Distribution
Expression Datasets
Phenotypes, Alleles and Disease Models
Biologically Significant Variants
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 419 5q32 GPR151 G protein-coupled receptor 151
Mouse 7 422 18 B3 Gpr151 G protein-coupled receptor 151
Rat 7 421 18p11 Gpr151 G protein-coupled receptor 151
Previous and Unofficial Names
PGR7
GALR4
GALRL
GPCR-2037
galanin receptor 4
GPR151
G-protein coupled receptor 151
G protein-coupled receptor 151
G-protein coupled receptor PGR7
putative G-protein coupled receptor
probable G-protein coupled receptor 151
galanin receptor-like GPCR
AXOR40
nGPCR-2037
putative G protein-coupled receptor nGPCR-2037
C130082O03Rik
Database Links
Ensembl ENSG00000173250 (Hs), ENSMUSG00000042816 (Mm), ENSRNOG00000027103 (Rn)
Entrez Gene 134391 (Hs), 240239 (Mm), 307475 (Rn)
GeneCards GPR151 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr151 (Mm)
HomoloGene 18754 (Hs)
Human Protein Reference Database 17065 (Hs)
InterPro Q8TDV0 (Hs), Q7TSN6 (Mm), Q7TSN5 (Rn)
KEGG Gene hsa:134391 (Hs), mmu:240239 (Mm), rno:307475 (Rn)
PharmGKB Gene PA134975199 (Hs)
PhosphoSitePlus Q8TDV0 (Hs), Q7TSN6 (Mm), Q7TSN5 (Rn)
Protein Ontology (PRO) PRO:000001513 (Hs)
RefSeq Nucleotide NM_194251 (Hs), NM_181543 (Mm), NM_181633 (Rn)
RefSeq Protein NP_919227 (Hs), NP_853521 (Mm), NP_853664 (Rn)
TreeFam ENSG00000173250 (Hs), ENSMUSG00000042816 (Mm), ENSRNOG00000027103 (Rn)
UniGene Hs. 483732 (Hs)
UniProt Q8TDV0 (Hs), Q7TSN6 (Mm), Q7TSN5 (Rn)
Wikipedia GPR151
Orphan and other 7TM receptors
Natural/Endogenous Ligand(s)
Comments: aka PGR7
Agonist Comments
GPR151 responded to galanin with an EC50 value of 2 uM. This suggests that the endogenous ligand shares structural features with galanin [1].
Tissue Distribution
Spinal cord, brain, peripheral organs and tissues such as testis, liver, kidney and stomach
Species:  Human
Technique:  Northern blot
References:  1
Spinal cord, brain, peripheral organs and tissues such as testis, liver, kidney and stomach
Species:  Mouse
Technique:  Northern blot
References:  1
Central nervous system and habenular complex
Species:  Mouse
Technique:  in situ hybridisation
References:  1
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr151tm1Dgen Gpr151tm1Dgen/Gpr151tm1Dgen
involves: 129P2/OlaHsd * C57BL/6		 MGI:2441887  MP:0002169 no abnormal phenotype detected
Biologically Significant Variants
L251V
SNP accession:  rs7709485 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
A144V
SNP accession:  rs7713676 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
A133G, low frequency (<10% in all tested populations)
SNP accession:  rs77075718 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
P40L, low frequency (<10% in all tested populations)
SNP accession:  rs17104742 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
General Comments
Both human and mouse GPR151 lack the well-conserved D-R-Y motif downstream of the third transmembrane domain [1].
Available Assays
DiscoveRx PathHunter® CHO-K1 GPR151 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0381C2A

REFERENCES

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1. Ignatov, A; Hermans-Borgmeyer, I; Schaller, HC. (2004) Cloning and characterization of a novel G-protein-coupled receptor with homology to galanin receptors. Neuropharmacology, 46 (8): 1114-20. [PMID:15111018]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: GPR151. Last modified on 05/11/2012. Accessed on 20/06/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=137.


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