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GPR146

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Expression Datasets
Biologically Significant Variants
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 333 7p22.3 GPR146 G protein-coupled receptor 146
Mouse 7 333 5 G1 Gpr146 G protein-coupled receptor 146
Rat 7 333 12q11 Gpr146 G protein-coupled receptor 146
Previous and Unofficial Names
PGR8
GPR146
G-protein coupled receptor 146
G-protein coupled receptor PGR8
AXOR120
LOC498153
RGD1560731
RGD1560731_predicted
G protein-coupled receptor 146
probable G-protein coupled receptor 146
similar to G protein-coupled receptor 146
similar to G protein-coupled receptor 146 (predicted)
BC003323
Database Links
Ensembl ENSG00000164849 (Hs), ENSMUSG00000044197 (Mm), ENSRNOG00000001288 (Rn)
Entrez Gene 115330 (Hs), 80290 (Mm), 498153 (Rn)
GeneCards GPR146 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr146 (Mm)
HomoloGene 36472 (Hs)
Human Protein Reference Database 17064 (Hs)
InterPro Q96CH1 (Hs), Q99LE2 (Mm)
KEGG Gene hsa:115330 (Hs), mmu:80290 (Mm), rno:498153 (Rn)
PharmGKB Gene PA134958088 (Hs)
PhosphoSitePlus Q96CH1 (Hs), Q99LE2 (Mm)
Protein Ontology (PRO) PRO:000001509 (Hs)
RefSeq Nucleotide NM_138445 (Hs), NM_030258 (Mm), NM_001109062 (Rn)
RefSeq Protein NP_612454 (Hs), NP_084534 (Mm), NP_001102532 (Rn)
TreeFam ENSG00000164849 (Hs), ENSMUSG00000044197 (Mm), ENSRNOG00000001288 (Rn)
UniGene Hs. 585007 (Hs)
UniProt Q96CH1 (Hs), Q99LE2 (Mm)
Wikipedia GPR146
Orphan and other 7TM receptors
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
G11E
SNP accession:  rs11761941 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
V266M, low frequency (<10% in all tested populations)
SNP accession:  rs55677825 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
General Comments
GPR146 is a member of Rhodopsin family of G-protein coupled receptors [1].
Available Assays
DiscoveRx PathHunter® CHO-K1 GPR146 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0365C2A
DiscoveRx PathHunter® eXpress GPR146 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0365E2ACP1

REFERENCES

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1. Gloriam, DE; Schiöth, HB; Fredriksson, R. (2005) Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Biochim. Biophys. Acta, 1722 (3): 235-46. [PMID:15777626]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: GPR146. Last modified on 05/11/2012. Accessed on 24/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=133.


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