image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing. 

GPR142

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Tissue Distribution
Expression Datasets
Clinically-Relevant Mutations and Pathophysiology
Biologically Significant Variants
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 462 17q23 GPR142 G protein-coupled receptor 142 1,3
Mouse 7 365 11 E2 Gpr142 G protein-coupled receptor 142 1,3
Rat 7 499 10q32.2 Gpr142 G protein-coupled receptor 142
Previous and Unofficial Names
PGR2
KIF19
GPR142
G-protein coupled receptor 142
G-protein coupled receptor PGR2
probable G-protein coupled receptor 142
AXOR103
LOC501735
RGD1559926
RGD1559926_predicted
G protein-coupled receptor 142
similar to G protein-coupled receptor 142
similar to G protein-coupled receptor 142 (predicted)
Database Links
Ensembl ENSG00000196169 (Hs), ENSMUSG00000034677 (Mm), ENSRNOG00000024446 (Rn)
Entrez Gene 350383 (Hs), 217302 (Mm), 303661 (Rn)
GeneCards GPR142 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr142 (Mm)
HomoloGene 18770 (Hs)
Human Protein Reference Database 16424 (Hs)
InterPro Q7Z601 (Hs), Q7TQN9 (Mm), F1LWD8 (Rn)
KEGG Gene hsa:350383 (Hs), mmu:217302 (Mm), rno:303661 (Rn)
OMIM 609046 (Hs)
PharmGKB Gene PA134891802 (Hs)
PhosphoSitePlus Q7Z601 (Hs), Q7TQN9 (Mm)
Protein Ontology (PRO) PRO:000001508 (Hs)
RefSeq Nucleotide NM_181790 (Hs), NM_181749 (Mm), XM_001081645 (Rn)
RefSeq Protein NP_861455 (Hs), NP_861414 (Mm), XP_001081645 (Rn)
TreeFam ENSG00000196169 (Hs), ENSMUSG00000034677 (Mm), ENSRNOG00000024446 (Rn)
UniGene Hs. 574368 (Hs)
UniProt Q7Z601 (Hs), Q7TQN9 (Mm), F1LWD8 (Rn)
Wikipedia GPR142
Orphan and other 7TM receptors
Agonist Comments
The high identity of 50% between GPR142 and GPR139 is suggestive of shared ligands [3].
Tissue Distribution
Spleen, liver, kidney, testis, brain
Species:  Mouse
Technique:  Multi-tissue cDNA panel (PCR)
References:  3
Brain (intense labeling of hippocampus, dentate gyrus, cerebral cortex, medial thalamic nuclei, anterior hypothalamic nuclei), thymus, liver, cartilage
Species:  Mouse
Technique:  In situ hybridization
References:  3
Tissue Distribution Comments
Embryonic expression of GPR142 suggests the receptor may play a role in brain, bone and blood formation [3].
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Clinically-Relevant Mutations and Pathophysiology
Comments:  Results from knockdown of a zebrafish GPCR ortholog previously determined to decrease fat content in C. Elegans support that future GPR142 antagonists may be effective non-toxic anti-obesity compounds.
References:  2
Mutations not determined
Biologically Significant Variants
R124Q, low frequency (<10% in all tested populations). SNP locates to amino terminal domain.
SNP accession:  rs73997706 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
General Comments
GPR142 exists in HEK-293 and CHO-K1 cell lines as a monomer [3].
Available Assays
DiscoveRx PathHunter® CHO-K1 GPR142 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0413C2A
DiscoveRx PathHunter® eXpress GPR142 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0413E2ACP1

REFERENCES

Show »

1. Fredriksson, R; Höglund, PJ; Gloriam, DE; Lagerström, MC; Schiöth, HB. (2003) Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett., 554 (3): 381-8. [PMID:14623098]

2. Jones, KS; Alimov, AP; Rilo, HL; Jandacek, RJ; Woollett, LA; Penberthy, WT. (2008) A high throughput live transparent animal bioassay to identify non-toxic small molecules or genes that regulate vertebrate fat metabolism for obesity drug development. Nutr Metab (Lond), 5: 23. [PMID:18752667]

3. Süsens, U; Hermans-Borgmeyer, I; Urny, J; Schaller, HC. (2006) Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development. Neuropharmacology, 50 (4): 512-20. [PMID:16378626]

To cite this database page, please use the following:

Amy E. Monaghan.
Class A Orphans: GPR142. Last modified on 05/11/2012. Accessed on 20/06/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=132.


Contact us | Print | Back to top | Help