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GPR135

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Tissue Distribution
Expression Datasets
Biologically Significant Variants
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 494 14q22.3 GPR135 G protein-coupled receptor 135
Mouse 7 457 12 C3 Gpr135 G protein-coupled receptor 135
Rat 7 457 6q24 Gpr135 G protein-coupled receptor 135
Previous and Unofficial Names
PAFR
HUMNPIIY20
GPR135
G-protein coupled receptor 135
probable G-protein coupled receptor 135
G protein-coupled receptor 135
Database Links
Ensembl ENSG00000181619 (Hs), ENSMUSG00000043398 (Mm), ENSRNOG00000004499 (Rn)
Entrez Gene 64582 (Hs), 238252 (Mm), 314213 (Rn)
GeneCards GPR135 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr135 (Mm)
HomoloGene 11211 (Hs)
Human Protein Reference Database 16263 (Hs)
InterPro Q8IZ08 (Hs), Q7TQP2 (Mm), Q7TQN7 (Rn)
KEGG Gene hsa:64582 (Hs), mmu:238252 (Mm), rno:314213 (Rn)
OMIM 607970 (Hs)
PharmGKB Gene PA134863427 (Hs)
PhosphoSitePlus Q8IZ08 (Hs), Q7TQP2 (Mm), Q7TQN7 (Rn)
Protein Ontology (PRO) PRO:000001505 (Hs)
RefSeq Nucleotide NM_022571 (Hs), NM_181752 (Mm), NM_181771 (Rn)
RefSeq Protein NP_072093 (Hs), NP_861417 (Mm), NP_861436 (Rn)
TreeFam ENSG00000181619 (Hs), ENSMUSG00000043398 (Mm), ENSRNOG00000004499 (Rn)
UniGene Hs. 647573 (Hs)
UniProt Q8IZ08 (Hs), Q7TQP2 (Mm), Q7TQN7 (Rn)
Wikipedia GPR135
Orphan and other 7TM receptors
Tissue Distribution
Neuron, stomach, eye, cervix, testis
Species:  Human
Technique:  Expressed sequence tag
References:  1
Pituitary
Species:  Human
Technique:  Northern Blot
References:  2
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Q5P
SNP accession:  rs1752428 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
V481A
SNP accession:  rs1752427 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
Available Assays
DiscoveRx PathHunter® CHO-K1 GPR135 (HUMNPIIY20) (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0431C2A
DiscoveRx PathHunter® eXpress GPR135 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0431E2ACP1

REFERENCES

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1. Fredriksson, R; Höglund, PJ; Gloriam, DE; Lagerström, MC; Schiöth, HB. (2003) Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett., 554 (3): 381-8. [PMID:14623098]

2. Vanti, W. B., Nguyen, T., Cheng, R., Lynch, K. R., George, S. R. and O'Dowd, B. F. (2003) Novel human G-protein-coupled receptors. Biochem Biophys Res Commun, 305: 67-71. [PMID:12732197]

To cite this database page, please use the following:

Amy E. Monaghan.
Class A Orphans: GPR135. Last modified on 05/11/2012. Accessed on 23/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=129.


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