image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing. 

GPR68

Family: Class A Orphans

See the Latest Pairings page for more information.

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Antagonists
Transduction Mechanisms
Tissue Distribution
Expression Datasets
Physiological Functions
Physiological Consequences of Altering Gene Expression
Phenotypes, Alleles and Disease Models
Gene Expression and Pathophysiology
Biologically Significant Variants
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 365 14q31 GPR68 G protein-coupled receptor 68 2,33
Mouse 7 365 12 E Gpr68 G protein-coupled receptor 68
Rat 7 375 6q32 Gpr68 G protein-coupled receptor 68
Previous and Unofficial Names
Sphingosylphosphorylcholine receptor
Ovarian cancer G-protein coupled receptor 1
OGR-1
GPR12A
MGC111379
OGR1
Gpr68_predicted
LOC314386
G protein-coupled receptor 68
G protein-coupled receptor 68 (predicted)
BB131428
Database Links
Ensembl ENSG00000119714 (Hs), ENSMUSG00000047415 (Mm), ENSRNOG00000027863 (Rn)
Entrez Gene 8111 (Hs), 238377 (Mm), 314386 (Rn)
GeneCards GPR68 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr68 (Mm)
HomoloGene 2603 (Hs)
Human Protein Reference Database 03241 (Hs)
InterPro Q15743 (Hs), Q8BFQ3 (Mm)
KEGG Gene hsa:8111 (Hs), mmu:238377 (Mm), rno:314386 (Rn)
OMIM 601404 (Hs)
PharmGKB Gene PA28911 (Hs)
PhosphoSitePlus Q15743 (Hs), Q8BFQ3 (Mm)
Protein Ontology (PRO) PRO:000001675 (Hs)
RefSeq Nucleotide NM_003485 (Hs), NM_175493 (Mm), NM_001108049 (Rn)
RefSeq Protein NP_003476 (Hs), NP_780702 (Mm), NP_001101519 (Rn)
TreeFam ENSG00000119714 (Hs), ENSMUSG00000047415 (Mm), ENSRNOG00000027863 (Rn)
UniGene Hs. 8882 (Hs)
UniProt Q15743 (Hs), Q8BFQ3 (Mm)
Wikipedia GPR68
Orphan and other 7TM receptors
Natural/Endogenous Ligand(s)
(lyso)phospholipid mediators
Agonist Comments
Gpr68 was previously identified as a receptor for sphingosyl phosphorylcholine (SPC) [31], but the original publication has been retracted [32]. SPC was later found to antagonise the proton-induced activation of the GPR68-mediated signaling pathways [18,25]. GPR68 is identified as a target of 3,5-disubstituted isoxazoles (Isx) [23].
Antagonist Comments
It has been reported by Wang et al. that psychosine antagonises pH responses by GPR68 [29].
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family
Gq/G11 family 		Adenylate cyclase inhibition
Phospholipase C stimulation
References:  14,16,30,34
Tissue Distribution
Spleen, testis, small intestine, peripheral blood leukocytes, brain, heart, lung, placenta and kidney. Not detected in thymus, prostate, ovary, colon, liver, skeletal muscle and pancreas.
Species:  Human
Technique:  Northen blot
References:  33
Osteosarcoma cells and primary osteoblast precursors
Species:  Human
Technique:  RT-PCR
References:  15
Abundantly expressed in lung. Also present in the placenta, spleen and testis.
Species:  Human
Technique:  Northen blot
References:  2
Aortic smooth muscle cells
Species:  Human
Technique:  RT-PCR
References:  14,27
Human cerebellar granule cell tumor cell line and primary human medulloblastoma tissue
Species:  Human
Technique:  RT-PCR
References:  7
Differentiated HL-60 neutrophil-like cells and human neutrophils
Species:  Human
Technique:  RT-PCR
References:  20
Human thyroid cancer cells (FRO cells) and normal human thyroid cells
Species:  Human
Technique:  RT-PCR
References:  1
Expressed in the αβ Jurkat and the γδ PEER T cell lines, the B cell lines RAJI and DAUDI, the myelogenous cell line K562 and IL-2-activated NK cells. Absent in CD16- and CD16+ resting NK cells.
Species:  Human
Technique:  RT-PCR
References:  9
Expressed in IL-12-and IL-15-activated NK cells, but not in IFN-α-activated cells.
Species:  Human
Technique:  RT-PCR
References:  9
Airway smooth muscle
Species:  Human
Technique:  RT-PCR
References:  8,24
Newborn myocardium, postnatal and injury-activated subepicardium, myocardial infarction-spared cardiomyocytes
Species:  Mouse
Technique:  Immunohistochemistry
References:  23
Peritoneal macrophage
Species:  Mouse
Technique:  RT-PCR
References:  17
Dorsal root ganglion, and mostly expressed in small-diameter neurons
Species:  Mouse
Technique:  in situ hybridisation
References:  6
Cuboidal/columar epithelial cells covering the large airways of the lung and vascular smooth muscles surrounding blood vessel in the lung.
Species:  Mouse
Technique:  Immunohistochemistry
References:  13
Thymocytes
Species:  Mouse
Technique:  RT-PCR
References:  29
Proximal tubules and collecting duct of mouse neuphron
Species:  Mouse
Technique:  RT-PCR
References:  19
Primary calvarial cells
Species:  Mouse
Technique:  RT-PCR
References:  5
Lung, testis, heart, brain, spleen, thymus, brown fat, small intestine, colon, peripheral blood leukocytes, macrophages, stomach, ovary, white fat and prostate. Not detected in liver, kidney and skeletal muscle.
Species:  Mouse
Technique:  RT-PCR
References:  13
Spleen, bladder, heart, small intestine, kidney, liver, lung, skeletal muscle, stomach, testis, cerebrum, brain stem, cerebellum, spinal cord, dorsal root ganglion, trigeminal ganglion.
Species:  Mouse
Technique:  RT-PCR
References:  6
Osteoclast
Species:  Rat
Technique:  Immunofluorescence
References:  10
Osteoblasts, osteocytes, chondrocytes of hypertrophic cartilage, epithelial cells of the lung, intestine, renal tubuli, skeletal myocytes, hepatocytes
Species:  Rat
Technique:  immunohistochemistry
References:  15
Tissue Distribution Comments
GPR68 was expressed early during mouse osteoclast differentiation in vivo and in vitro [34]. GPR68 was strongly regulated in vivo after 2 days of colony stimulating factor-1 treatment [34]. High levels of GPR68 mRNA were detected by microarray, RT-PCR and immunoblotting when mouse bone marrow mononuclear cells and RAW 264.7 pre-osteoclast-like cells were treated with RANKL to induce osteoclast differentiation [10,34].
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Physiological Functions
Involved in acidic pH-stimulated connective tissue growth factor (CTGF) production in human airway smooth muscle cells.
Species:  Human
Tissue:  Airway smooth muscle cells
References:  16
Acts as pH sensor and mediates calcium release from the bone during metabolic acidosis.
Species:  Mouse
Tissue:  Bone cells
References:  4-5
Acts as a proton-sensing receptor stimulating inositol phosphate formation and subsequently intracellular calcium mobilisation.
Species:  Human
Tissue:  HEK293 cells
References:  15
Involved in acidification-stimulated IL-6 production and Ca2+ mobilisation in human airway smooth muscle cells.
Species:  Human
Tissue:  Airway smooth muscle cells
References:  8
Regulate osteoblastic COX-2 inductiona and PGE2 production in response to acidic pH via GPR68/Gq/phospholipase C/protein kinase C pathway.
Species:  Human
Tissue:  Osteoblatic cell line
References:  28
Regulate the activity of two proton transport system, NHE3 and H+-ATPase.
Species:  Mouse
Tissue:  Proximal tubules
References:  19
Physiological Functions Comments
GPR68 transciently increases intracellular calcium, mediates SPC-induced ERK1/2 activation and inhibits cellular proliferation [3]. GPR68 causes cAMP accumulation and inositol phosphate production upon stimulation by extracellular acidification [18].
Physiological Consequences of Altering Gene Expression
Overexpression of GPR68 enhances SPC-induced activation of ERK1/2.
Species:  Human
Tissue:  HEK 293 cells
Technique:  Gene knockout
References:  3
Expression of GPR68 in vitro inhibits cell migration via Gi activation and the secretion of a hydrophobic factor.
Species:  Human
Tissue:  PC3 cells (Human prostate cancer cells)
Technique:  Gene overexpression
References:  14
Reduction of metastases was observed in mice when PC3 cells with expression of exogenous GPR68 were injected into mice.
Species:  Mouse
Tissue:  Prostate cancer cell
Technique:  Gene overexpression
References:  14
Overpression of GPR68 in human ovarian cancer cells inhibits cell proliferation and migration, but enhances cell adhesion to the extracellular matrix.
Species:  Human
Tissue:  HEY cells (human ovarian carcinoma cell line)
Technique:  Gene overexpression
References:  22
The acid-induced inositol phosphate production, [Ca2+]i increase, cAMP accumulation and prostaglandin I2 production in human aortic smooth muscle cells were inhibited by GPT68 siRNA.
Species:  Human
Tissue:  Aortic smooth muscle cells
Technique:  RNA interference
References:  26
RANKL-induced differentiation of both mouse bone marrow mononuclear cells and RAW 264.7 pre-osteoclast-like cells is inhibited in vitro.
Species:  Mouse
Tissue:  Bone marrow cells and pre-osteoclast-like cells
Technique:  RNA interference and and anti-GPR immunofluorescence
References:  34
Acid-induced rise of [Ca2+]i was inhibited in osteoclast-like cells.
Species:  Mouse
Tissue:  RAW 264.7 cell
Technique:  RNA interference
References:  21
Small interfering RNA directed against GPR68 inhibits acidification-induced PGI2 production, COX-2 induction and MAPK phosphatase-1 expression in human aortic smooth muscle cells.
Species:  Human
Tissue:  Aortic smooth muscle cells
Technique:  RNA interference
References:  14
Mice with GPR68 knockout show upregulated expression of Pyk2 and a significant increase in sodium-hydrogen antiporter (NHE) activity.
Species:  Mouse
Tissue:  Proximal tubules
Technique:  Gene knockout
References:  19
Proton-induced COX-2 protein expression and PGE2 production were markedly inhibited in osteoblast with GPR68 knockdown.
Species:  Human
Tissue:  Osteoblastic cell line
Technique:  RNA interference
References:  28
Reduced osteoblasts and decreased melanoma cell tumorigenesis were observed in Gpr68 deficient mice.
Species:  Mouse
Tissue: 
Technique:  Gene knockouts
References:  13
Physiological Consequences of Altering Gene Expression Comments
Knockout of GPR68 in mouse macrophages did not affect the acidic pH-induced inhibitory action on cytokine production [17].
Phenotypes, Alleles and Disease Models Mouse data from MGI

Click here to show/hide data

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr68tm1.1Yaxu Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
involves: 129S4/SvJae * C57BL/6 * FVB/N		 MGI:2441763  MP:0002971 abnormal brown adipose tissue morphology PMID: 19479052 
Gpr68tm1Yaxu Gpr68tm1Yaxu/Gpr68tm1Yaxu
involves: C57BL/6		 MGI:2441763  MP:0002971 abnormal brown adipose tissue morphology PMID: 19479052 
Gpr68tm1.1Yaxu Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
involves: 129S4/SvJae * C57BL/6 * FVB/N		 MGI:2441763  MP:0002451 abnormal macrophage physiology PMID: 19479052 
Gpr68tm1Yaxu Gpr68tm1Yaxu/Gpr68tm1Yaxu
involves: C57BL/6		 MGI:2441763  MP:0002451 abnormal macrophage physiology PMID: 19479052 
Gpr68tm1.1Yaxu Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
B6.Cg-Gpr68		 MGI:2441763  MP:0008396 abnormal osteoclast differentiation PMID: 19479052 
Gpr68tm1.1Yaxu Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
involves: 129S4/SvJae * C57BL/6 * FVB/N		 MGI:2441763  MP:0008396 abnormal osteoclast differentiation PMID: 19479052 
Gpr68tm1Yaxu Gpr68tm1Yaxu/Gpr68tm1Yaxu
involves: C57BL/6		 MGI:2441763  MP:0008396 abnormal osteoclast differentiation PMID: 19479052 
Gpr68tm1.1Yaxu Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
B6.Cg-Gpr68		 MGI:2441763  MP:0001541 abnormal osteoclast physiology PMID: 19479052 
Gpr68tm1.1Yaxu Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
involves: 129S4/SvJae * C57BL/6 * FVB/N		 MGI:2441763  MP:0001541 abnormal osteoclast physiology PMID: 19479052 
Gpr68tm1Yaxu Gpr68tm1Yaxu/Gpr68tm1Yaxu
involves: C57BL/6		 MGI:2441763  MP:0001541 abnormal osteoclast physiology PMID: 19479052 
Gpr68tm1Yaxu Gpr68tm1Yaxu/Gpr68tm1Yaxu
involves: C57BL/6		 MGI:2441763  MP:0001780 decreased brown adipose tissue amount PMID: 19479052 
Gpr68tm1.1Yaxu Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
involves: 129S4/SvJae * C57BL/6 * FVB/N		 MGI:2441763  MP:0003884 decreased macrophage cell number PMID: 19479052 
Gpr68tm1Yaxu Gpr68tm1Yaxu/Gpr68tm1Yaxu
involves: C57BL/6		 MGI:2441763  MP:0000223 decreased monocyte cell number PMID: 19479052 
Gpr68tm1.1Yaxu Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
B6.Cg-Gpr68		 MGI:2441763  MP:0003447 decreased tumor growth/size PMID: 19479052 
Gpr68tm1.1Yaxu Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
involves: 129S4/SvJae * C57BL/6 * FVB/N		 MGI:2441763  MP:0003447 decreased tumor growth/size PMID: 19479052 
Gpr68tm1.1Yaxu Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
involves: 129S4/SvJae * C57BL/6 * FVB/N		 MGI:2441763  MP:0000005 increased brown adipose tissue amount PMID: 19479052 
Gpr68tm1.1Yaxu Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
involves: 129S4/SvJae * C57BL/6 * FVB/N		 MGI:2441763  MP:0000220 increased monocyte cell number PMID: 19479052 
Gpr68tm1Yaxu Gpr68tm1Yaxu/Gpr68tm1Yaxu
involves: C57BL/6		 MGI:2441763  MP:0003721 increased tumor growth/size PMID: 19479052 
Gene Expression and Pathophysiology Comments
GPR68 expression was shown to be fivefold lower in metastatic prostate cancers than primary prostate cancers [12]. Gene expression of GPR68 is changed in ASIC3 knockout mice [6]. GPR68 has been reported as a novel metastasis suppressor gene for prostate cancer [14].
Biologically Significant Variants
R53Q, low frequency (<10% in all tested populations)
SNP accession:  rs2230339 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
General Comments
GPR68 is fully activated at pH 6.8, but almost silent at pH 7.8 [15]. Several His residues that reside in the extracellular domain of GPR68 are shown to be responsible for the proton binding, pH-sensing activity of GPR68 [15]. GPR68 forms very weak homodimer and relatively weak heterodimers with other receptors (LPA and GPR4) [35]. GPR68 is coupled to IP3-mediated Cai signaling in osteoblasts [11].

REFERENCES

Show »

1. Afrasiabi, E; Blom, T; Ekokoski, E; Tuominen, RK; Törnquist, K. (2006) Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. Cell. Signal., 18 (10): 1671-8. [PMID:16490345]

2. An, S; Tsai, C; Goetzl, EJ. (1995) Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue. FEBS Lett., 375 (1-2): 121-4. [PMID:7498459]

3. Bektas, M; Barak, LS; Jolly, PS; Liu, H; Lynch, KR; Lacana, E; Suhr, KB; Milstien, S; Spiegel, S. (2003) The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner. Biochemistry, 42 (42): 12181-91. [PMID:14567679]

4. Frick, KK; Bushinsky, DA. (2010) Effect of metabolic and respiratory acidosis on intracellular calcium in osteoblasts. Am. J. Physiol. Renal Physiol., 299 (2): F418-25. [PMID:20504884]

5. Frick, KK; Krieger, NS; Nehrke, K; Bushinsky, DA. (2009) Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1. J. Bone Miner. Res., 24 (2): 305-13. [PMID:18847331]

6. Huang, CW; Tzeng, JN; Chen, YJ; Tsai, WF; Chen, CC; Sun, WH. (2007) Nociceptors of dorsal root ganglion express proton-sensing G-protein-coupled receptors. Mol. Cell. Neurosci., 36 (2): 195-210. [PMID:17720533]

7. Huang, WC; Swietach, P; Vaughan-Jones, RD; Ansorge, O; Glitsch, MD. (2008) Extracellular acidification elicits spatially and temporally distinct Ca2+ signals. Curr. Biol., 18 (10): 781-5. [PMID:18485712]

8. Ichimonji, I; Tomura, H; Mogi, C; Sato, K; Aoki, H; Hisada, T; Dobashi, K; Ishizuka, T; Mori, M; Okajima, F. (2010) Extracellular acidification stimulates IL-6 production and Ca(2+) mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol., 299 (4): L567-77. [PMID:20656891]

9. Jin, Y; Damaj, BB; Maghazachi, AA. (2005) Human resting CD16-, CD16+ and IL-2-, IL-12-, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor. Eur. J. Immunol., 35 (9): 2699-708. [PMID:16078278]

10. Komarova, SV; Pereverzev, A; Shum, JW; Sims, SM; Dixon, SJ. (2005) Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Proc. Natl. Acad. Sci. U.S.A., 102 (7): 2643-8. [PMID:15695591]

11. Krieger, NS; Bushinsky, DA. (2011) Pharmacological inhibition of intracellular calcium release blocks acid-induced bone resorption. Am. J. Physiol. Renal Physiol., 300 (1): F91-7. [PMID:21048027]

12. LaTulippe, E; Satagopan, J; Smith, A; Scher, H; Scardino, P; Reuter, V; Gerald, WL. (2002) Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease. Cancer Res., 62 (15): 4499-506. [PMID:12154061]

13. Li, H; Wang, D; Singh, LS; Berk, M; Tan, H; Zhao, Z; Steinmetz, R; Kirmani, K; Wei, G; Xu, Y. (2009) Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1. PLoS ONE, 4 (5): e5705. [PMID:19479052]

14. Liu, JP; Komachi, M; Tomura, H; Mogi, C; Damirin, A; Tobo, M; Takano, M; Nochi, H; Tamoto, K; Sato, K; Okajima, F. (2010) Ovarian cancer G protein-coupled receptor 1-dependent and -independent vascular actions to acidic pH in human aortic smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol., 299 (3): H731-42. [PMID:20622109]

15. Ludwig, MG; Vanek, M; Guerini, D; Gasser, JA; Jones, CE; Junker, U; Hofstetter, H; Wolf, RM; Seuwen, K. (2003) Proton-sensing G-protein-coupled receptors. Nature, 425 (6953): 93-8. [PMID:12955148]

16. Matsuzaki, S; Ishizuka, T; Yamada, H; Kamide, Y; Hisada, T; Ichimonji, I; Aoki, H; Yatomi, M; Komachi, M; Tsurumaki, H; et al.. (2011) Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells. Biochem. Biophys. Res. Commun., 413 (4): 499-503. [PMID:21907704]

17. Mogi, C; Tobo, M; Tomura, H; Murata, N; He, XD; Sato, K; Kimura, T; Ishizuka, T; Sasaki, T; Sato, T; Kihara, Y; Ishii, S; Harada, A; Okajima, F. (2009) Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages. J. Immunol., 182 (5): 3243-51. [PMID:19234222]

18. Mogi, C; Tomura, H; Tobo, M; Wang, JQ; Damirin, A; Kon, J; Komachi, M; Hashimoto, K; Sato, K; Okajima, F. (2005) Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation. J. Pharmacol. Sci., 99 (2): 160-7. [PMID:16210776]

19. Mohebbi, N; Benabbas, C; Vidal, S; Daryadel, A; Bourgeois, S; Velic, A; Ludwig, MG; Seuwen, K; Wagner, CA. (2012) The proton-activated G protein coupled receptor OGR1 acutely regulates the activity of epithelial proton transport proteins. Cell. Physiol. Biochem., 29 (3-4): 313-24. [PMID:22508039]

20. Murata, N; Mogi, C; Tobo, M; Nakakura, T; Sato, K; Tomura, H; Okajima, F. (2009) Inhibition of superoxide anion production by extracellular acidification in neutrophils. Cell. Immunol., 259 (1): 21-6. [PMID:19539899]

21. Pereverzev, A; Komarova, SV; Korcok, J; Armstrong, S; Tremblay, GB; Dixon, SJ; Sims, SM. (2008) Extracellular acidification enhances osteoclast survival through an NFAT-independent, protein kinase C-dependent pathway. Bone, 42 (1): 150-61. [PMID:17964236]

22. Ren, J; Zhang, L. (2011) Effects of ovarian cancer G protein coupled receptor 1 on the proliferation, migration, and adhesion of human ovarian cancer cells. Chin. Med. J., 124 (9): 1327-32. [PMID:21740742]

23. Russell, JL; Goetsch, SC; Aguilar, HR; Coe, H; Luo, X; Liu, N; van Rooij, E; Frantz, DE; Schneider, JW. (2012) Regulated expression of pH sensing G Protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease. ACS Chem. Biol., 7 (6): 1077-83. [PMID:22462679]

24. Saxena, H; Deshpande, DA; Tiegs, BC; Yan, H; Battafarano, RJ; Burrows, WM; Damera, G; Panettieri, RA; Dubose, TD; An, SS; et al.. (2012) The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH. Br. J. Pharmacol., 166 (3): 981-90. [PMID:22145625]

25. Seuwen, K; Ludwig, MG; Wolf, RM. (2006) Receptors for protons or lipid messengers or both?. J. Recept. Signal Transduct. Res., 26 (5-6): 599-610. [PMID:17118800]

26. Tomura, H; Mogi, C; Sato, K; Okajima, F. (2005) Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: a novel type of multi-functional receptors. Cell. Signal., 17 (12): 1466-76. [PMID:16014326]

27. Tomura, H; Wang, JQ; Komachi, M; Damirin, A; Mogi, C; Tobo, M; Kon, J; Misawa, N; Sato, K; Okajima, F. (2005) Prostaglandin I(2) production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells. J. Biol. Chem., 280 (41): 34458-64. [PMID:16087674]

28. Tomura, H; Wang, JQ; Liu, JP; Komachi, M; Damirin, A; Mogi, C; Tobo, M; Nochi, H; Tamoto, K; Im, DS; Sato, K; Okajima, F. (2008) Cyclooxygenase-2 expression and prostaglandin E2 production in response to acidic pH through OGR1 in a human osteoblastic cell line. J. Bone Miner. Res., 23 (7): 1129-39. [PMID:18302504]

29. Wang, JQ; Kon, J; Mogi, C; Tobo, M; Damirin, A; Sato, K; Komachi, M; Malchinkhuu, E; Murata, N; Kimura, T; Kuwabara, A; Wakamatsu, K; Koizumi, H; Uede, T; Tsujimoto, G; Kurose, H; Sato, T; Harada, A; Misawa, N; Tomura, H; Okajima, F. (2004) TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor. J. Biol. Chem., 279 (44): 45626-33. [PMID:15326175]

30. Xu, Y. (2002) Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction. Biochim. Biophys. Acta, 1582 (1-3): 81-8. [PMID:12069813]

31. Xu, Y., Zhu, K., Hong, G., Wu, W., Baudhuin, L. M., Xiao, Y. and Damron, D. S. (2000) Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. Nat Cell Biol, 2: 261-267. [PMID:10806476]

32. Xu, Y., Zhu, K., Hong, G., Wu, W., Baudhuin, L.M., Xiao, Y. and Damron, D.S. (2006) Retraction of:
Xu Y, Zhu K, Hong G, Wu W, Baudhuin LM, Xiao Y, Damron DS.(2000) Nat Cell Biol. 2(5):261-7. Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. Nat Cell Biol, 8: 299-. [PMID:16508674]

33. Xu, Y; Casey, G. (1996) Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14. Genomics, 35 (2): 397-402. [PMID:8661159]

34. Yang, M; Mailhot, G; Birnbaum, MJ; MacKay, CA; Mason-Savas, A; Odgren, PR. (2006) Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis. J. Biol. Chem., 281 (33): 23598-605. [PMID:16787916]

35. Zaslavsky, A; Singh, LS; Tan, H; Ding, H; Liang, Z; Xu, Y. (2006) Homo- and hetero-dimerization of LPA/S1P receptors, OGR1 and GPR4. Biochim. Biophys. Acta, 1761 (10): 1200-12. [PMID:17023202]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: GPR68. Last modified on 02/11/2012. Accessed on 19/06/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=114.


Contact us | Print | Back to top | Help