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GPR37L1

Family: Class A Orphans

This receptor has a proposed ligand; see the Latest Pairings page for more information.

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Tissue Distribution
Expression Datasets
Physiological Consequences of Altering Gene Expression
Phenotypes, Alleles and Disease Models
Biologically Significant Variants
General Comments
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 481 1q32.1 GPR37L1 G protein-coupled receptor 37 like 1 5
Mouse 7 481 1 E4 Gpr37l1 G protein-coupled receptor 37-like 1 3
Rat 7 481 13q13 Gpr37l1 G protein-coupled receptor 37-like 1
Previous and Unofficial Names
G-protein coupled receptor 37-like 1
D0Kist8
CAG-18
ETBR-LP-2
GPR37L1
ET(B)R-LP-2
ETBRLP2
G protein-coupled receptor 37 like 1
endothelin B receptor-like protein 2
G-protein coupled receptor CNS2
AW047233
Database Links
ChEMBL Target 101369 (Hs)
Ensembl ENSG00000170075 (Hs), ENSMUSG00000026424 (Mm), ENSRNOG00000006237 (Rn)
Entrez Gene 9283 (Hs), 171469 (Mm), 252939 (Rn)
GeneCards GPR37L1 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr37l1 (Mm)
HomoloGene 3500 (Hs)
Human Protein Reference Database 13603 (Hs)
InterPro O60883 (Hs), Q99JG2 (Mm), Q9QYC5 (Rn)
KEGG Gene hsa:9283 (Hs), mmu:171469 (Mm), rno:252939 (Rn)
PharmGKB Gene PA28883 (Hs)
PhosphoSitePlus O60883 (Hs), Q99JG2 (Mm), Q9QYC5 (Rn)
Protein Ontology (PRO) PRO:000001112 (Hs)
RefSeq Nucleotide NM_004767 (Hs), NM_134438 (Mm), NM_145784 (Rn)
RefSeq Protein NP_004758 (Hs), NP_602320 (Mm), NP_665727 (Rn)
TreeFam ENSG00000170075 (Hs), ENSMUSG00000026424 (Mm), ENSRNOG00000006237 (Rn)
UniGene Hs. 132049 (Hs)
UniProt O60883 (Hs), Q99JG2 (Mm), Q9QYC5 (Rn)
Wikipedia GPR37L1
Orphan and other 7TM receptors
Tissue Distribution
Cerebellum, cortex, medulla, spinal cord, putamen, occipital, frontal, temporal lobes
Species:  Human
Technique:  Northern blot.
References:  6
Highly expressed in cerebellar Bergmann glia of the Purkinje cell layer, internal capsule fibers of the caudate putamen and in temporal cortex
Species:  Human
Technique:  in situ hybridisation
References:  6
Muscle-myenteric nerve layer of gastrointestinal tract
Species:  Mouse
Technique:  RT-PCR
References:  1
Tissue Distribution Comments
No transcripts of GPR37L1 were detected in peripheral tissues such as heart, placenta, lung, liver, skeletal muscle, kidney and pancreas when examined by Northen blot [6].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Consequences of Altering Gene Expression
Mice with GPR37L1 knockout show high blood pressure and high heart weight/ body weight (HW/BW).
Species:  Mouse
Tissue:  Heart
Technique:  knockout by gene targeting in embryonic stem cells
References:  4
Overexpression of GPR37L1 induces apoptosis of cardiomyocytes.
Species:  Mouse
Tissue:  Cardiomyocytes
Technique:  Gene overexpression
References:  4
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr37l1tm1Lex Gpr37l1tm1Lex/Gpr37l1tm1Lex
involves: 129S5/SvEvBrd * C57BL/6J		 MGI:1928503  MP:0002169 no abnormal phenotype detected
Biologically Significant Variants
P81A
SNP accession:  rs3795594 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
D90G
SNP accession:  rs3795595 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
General Comments
It is shown that folic acid supplementation decreased the expression of GPR37L1 in a dose-dependent manner [2].
Available Assays
DiscoveRx PathHunter® CHO-K1 GPR37L1 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0378C2A
DiscoveRx PathHunter® eXpress GPR37L1 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0378E2ACP1

REFERENCES

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1. Ito, J; Ito, M; Nambu, H; Fujikawa, T; Tanaka, K; Iwaasa, H; Tokita, S. (2009) Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice. Cell Tissue Res., 338 (2): 257-69. [PMID:19763624]

2. Junaid, MA; Kuizon, S; Cardona, J; Azher, T; Murakami, N; Pullarkat, RK; Brown, WT. (2011) Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem. Biophys. Res. Commun., 412 (4): 688-92. [PMID:21867686]

3. Kim, SJ; Shon, BH; Kang, JH; Hahm, KS; Yoo, OJ; Park, YS; Lee, KK. (1997) Cloning of novel trinucleotide-repeat (CAG) containing genes in mouse brain. Biochem. Biophys. Res. Commun., 240 (1): 239-43. [PMID:9367917]

4. Min, KD; Asakura, M; Liao, Y; Nakamaru, K; Okazaki, H; Takahashi, T; Fujimoto, K; Ito, S; Takahashi, A; Asanuma, H; Yamazaki, S; Minamino, T; Sanada, S; Seguchi, O; Nakano, A; Ando, Y; Otsuka, T; Furukawa, H; Isomura, T; Takashima, S; Mochizuki, N; Kitakaze, M. (2010) Identification of genes related to heart failure using global gene expression profiling of human failing myocardium. Biochem. Biophys. Res. Commun., 393 (1): 55-60. [PMID:20100464]

5. Valdenaire, O., Giller, T., Breu, V., Gottowik, J. and Kilpatrick, G. (1997) A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor. Biochim Biophys Acta., 1352: 129-132. [PMID:9199241]

6. Valdenaire, O; Giller, T; Breu, V; Ardati, A; Schweizer, A; Richards, JG. (1998) A new family of orphan G protein-coupled receptors predominantly expressed in the brain. FEBS Lett., 424 (3): 193-6. [PMID:9539149]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: GPR37L1. Last modified on 02/11/2012. Accessed on 19/06/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=104.


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