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oxoglutarate receptor

Family: Oxoglutarate receptor

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Agonists
Transduction Mechanisms
Tissue Distribution
Expression Datasets
Gene Expression and Pathophysiology
Biologically Significant Variants
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 337 13q32.2 OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1
Mouse 7 337 14 E4 Oxgr1 oxoglutarate (alpha-ketoglutarate) receptor 1
Rat 7 337 15q24 Oxgr1 oxoglutarate (alpha-ketoglutarate) receptor 1
Previous and Unofficial Names
oxoglutarate (alpha-ketoglutarate) receptor 1
GPR99
GPR80
P2RY15
P2Y15
LOC239283
MGC119206
MGC119207
MGC119208
OXGR1
Alpha-ketoglutarate receptor 1
G-protein coupled receptor 80
P2Y-like GPCR
G-protein coupled receptor 99
P2Y-like nucleotide receptor
P2Y purinoceptor 15
2-oxoglutarate receptor 1
G protein-coupled receptor 99
G protein-coupled receptor 80
Gm299
Database Links
ChEMBL Target 12241 (Rn)
Ensembl ENSG00000165621 (Hs), ENSMUSG00000044819 (Mm), ENSRNOG00000037884 (Rn)
Entrez Gene 27199 (Hs), 239283 (Mm), 290493 (Rn)
GeneCards OXGR1 (Hs)
GenitoUrinary Development Molecular Anatomy Project Oxgr1 (Mm)
HomoloGene 25878 (Hs)
Human Protein Reference Database 06082 (Hs)
InterPro Q96P68 (Hs), Q6IYF8 (Mm), Q6Y1R5 (Rn)
KEGG Gene hsa:27199 (Hs), mmu:239283 (Mm), rno:290493 (Rn)
OMIM 606922 (Hs)
PharmGKB Gene PA28924 (Hs)
Protein Ontology (PRO) PRO:000001097 (Hs)
RefSeq Nucleotide NM_080818 (Hs), NM_001001490 (Mm), NM_207588 (Rn)
RefSeq Protein NP_543008 (Hs), NP_001001490 (Mm), NP_997471 (Rn)
TreeFam ENSG00000165621 (Hs), ENSMUSG00000044819 (Mm), ENSRNOG00000037884 (Rn)
UniGene Hs. 352218 (Hs)
UniProt Q96P68 (Hs), Q6IYF8 (Mm), Q6Y1R5 (Rn)
Wikipedia oxoglutarate receptor
Oxoglutarate receptor
Search for 3D structures on the PDB
Search by keyword: Oxoglutarate receptor oxoglutarate receptor Search by accession number: Q6Y1R5, Q96P68, Q6IYF8
Natural/Endogenous Ligand(s)
α-ketoglutaric acid
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[3H]LTE4 Mm Agonist 8.6 pKd 4
α-ketoglutaric acid Hs Full agonist 4.16 – 4.49 pEC50 2
View species-specific agonist tables
Agonist Comments
It was reported that OXGR1 responded to adenosine monophosphate (AMP) and adenosine [3]. However, this claim has been retracted [1].
Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
References:  2
Tissue Distribution
Kidney and placenta
Species:  Human
Technique:  Northern blot
References:  7
Trachea, salivary glands, kidney, fetal brain and lung showed the highest expression levels among the tissues examined.
Species:  Human
Technique:  RT-PCR
References:  3
Mast cells
Species:  Human
Technique:  Microarray analysis
References:  3
Kidney, testis and smooth muscle
Species:  Mouse
Technique:  RT-PCR
References:  2
Distal tubules in the cortical region of kidney
Species:  Mouse
Technique:  in situ hybridisation
References:  2
Tissue Distribution Comments
No transcripts of OXGR1 were detected by Northern blot analysis in human brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus and pons tissues [5].
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Gene Expression and Pathophysiology Comments
DNA hypermethylation of OXGR1 is found to occur frequently in hepatocellular carcinoma [6]. It is also shown that restoration of the OXGR1 expression enhanced the sensitivity of hepatoma cell lines to anticancer drugs, 5-fluorouracil and doxorubicin [6].
Biologically Significant Variants
R63G
SNP accession:  rs9300380 
Type:  Naturally occurring SNPs.
Species:  Human
References: 
Available Assays
DiscoveRx PathHunter® CHO-K1 OXGR1 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0693C2
DiscoveRx PathHunter® eXpress OXGR1 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0693E2CP1

REFERENCES

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1. Abbracchio, M. P., Burnstock, G., Boeynaems, J. M., Barnard, E. A., Boyer, J. L., Kennedy, C., Miras-Portugal, M. T., King, B. F., Gachet, C., Jacobson, K. A. and Weisman, G. A. (2005) The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor. Trends Pharmacol Sci, 26: 8-9. [PMID:15629198]

2. He, W., Miao, F. J., Lin, D. C., Schwandner, R. T., Wang, Z., Gao, J., Chen, J. L., Tian, H. and Ling, L. (2004) Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. Nature, 429: 188-193. [PMID:15141213]

3. Inbe, H; Watanabe, S; Miyawaki, M; Tanabe, E; Encinas, JA. (2004) Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine. J. Biol. Chem., 279 (19): 19790-9. [PMID:15001573]

4. Kanaoka, Y; Maekawa, A and Austen, KF. (2013) Identification of GPR99 as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4. The Journal of Biological Chemistry, .

5. Lee, D. K., Nguyen, T., Lynch, K. R., Cheng, R., Vanti, W. B., Arkhitko, O., Lewis, T., Evans, J. F., George, S. R. and O'Dowd, B. F. (2001) Discovery and mapping of ten novel G protein-coupled receptor genes. Gene, 275: 83-91. [PMID:11574155]

6. Lu, CY; Hsieh, SY; Lu, YJ; Wu, CS; Chen, LC; Lo, SJ; Wu, CT; Chou, MY; Huang, TH; Chang, YS. (2009) Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma. Genes Chromosomes Cancer, 48 (12): 1057-68. [PMID:19760608]

7. Wittenberger, T; Hellebrand, S; Munck, A; Kreienkamp, HJ; Schaller, HC; Hampe, W. (2002) GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors. BMC Genomics, 3: 17. [PMID:12098360]

To cite this database page, please use the following:

Wen Chiy Liew.
Oxoglutarate receptor: oxoglutarate receptor. Last modified on 18/03/2013. Accessed on 23/05/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=162.


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