IUPHAR DATABASE | 5A. Fushi tarazu F1-like receptors

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Liver receptor homolog-1

Systematic Nomenclature: NR5A2

Family: 5A. Fushi tarazu F1-like receptors

Contents:

Gene and Protein Information

Previous and Unofficial Names

Database Links

Selected 3D Structures

Physiological Consequences of Altering Gene Expression

Phenotypes, Alleles and Disease Models

Biologically Significant Variants

References

Gene and Protein Information
Species	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	541	1q32.1	NR5A2	nuclear receptor subfamily 5, group A, member 2	8
Mouse	560	1 78.0cM	Nr5a2	nuclear receptor subfamily 5, group A, member 2	18
Rat	560	13q13	Nr5a2	nuclear receptor subfamily 5, group A, member 2	9

Previous and Unofficial Names
LRH-1
FTZ-F1β
hB1F
FTZ-F1
hB1F-2
B1F2
Liver receptor homologue 1
α1-fetoprotein transcription factor
hepatocytic transcription factor
B1-binding factor
CYP7A promoter-binding factor
FTF
FTZ-F1beta
liver receptor homolog-1
FTZ-F1 beta
FTZ-F1 beta2 protein
fetoprotein transcription factor
liver receptor homolog 1
nuclear receptor subfamily 5 group A member 2
nuclear receptor subfamily 5, group A, member 2
D1Ertd308e
AU020803

Previous and Unofficial Names

LRH-1

FTZ-F1β

hB1F

FTZ-F1

hB1F-2

B1F2

Liver receptor homologue 1

α1-fetoprotein transcription factor

hepatocytic transcription factor

B1-binding factor

CYP7A promoter-binding factor

FTF

FTZ-F1beta

liver receptor homolog-1

FTZ-F1 beta

FTZ-F1 beta2 protein

fetoprotein transcription factor

liver receptor homolog 1

nuclear receptor subfamily 5 group A member 2

nuclear receptor subfamily 5, group A, member 2

D1Ertd308e

AU020803

Database Links
ChEMBL Target	100827 (Hs)
Ensembl	ENSG00000116833 (Hs), ENSMUSG00000026398 (Mm), ENSRNOG00000000653 (Rn)
Entrez Gene	2494 (Hs), 26424 (Mm), 60349 (Rn)
GeneCards	NR5A2 (Hs)
GenitoUrinary Development Molecular Anatomy Project	Nr5a2 (Mm)
HomoloGene	20827 (Hs)
Human Protein Reference Database	06830 (Hs)
InterPro	O00482 (Hs), P45448 (Mm), Q9QWM1 (Rn)
KEGG Gene	hsa:2494 (Hs), mmu:26424 (Mm), rno:60349 (Rn)
NURSA Receptor	5A2
OMIM	604453 (Hs)
PharmGKB Gene	PA31765 (Hs)
PhosphoSitePlus	O00482 (Hs), P45448 (Mm), Q9QWM1 (Rn)
RefSeq Nucleotide	NM_003822 (Hs), NM_001159769 (Mm), NM_030676 (Mm), NM_021742 (Rn)
RefSeq Protein	NP_003813 (Hs), NP_995582 (Hs), NP_109601 (Mm), NP_068510 (Rn)
TreeFam	ENSG00000116833 (Hs), ENSMUSG00000026398 (Mm), ENSRNOG00000000653 (Rn)
UniProt	O00482 (Hs), P45448 (Mm), Q9QWM1 (Rn)
	Orphan nuclear receptors

Selected 3D Structures

Image of receptor 3D structure from RCSB PDB

Description:	LRH-1 Ligand Binding Domain
PDB Id:	1PK5
Resolution:	2.4Å
Species:	Human
References:	21

Search for other structures on the PDB

Search by keyword: Liver receptor homolog-1

Search by accession number: O00482, Q9QWM1, P45448

Natural/Endogenous Ligand(s)
Comments: Orphan

DNA Binding

Structure:	Monomer
HRE core sequence:	YCA AGG YCR
Response element:	Half site

DNA Binding Comments

In the NR5A subfamily, specificity of DNA binding is dictated by the Ftz-F1 box, which is a stretch of 26 amino acids at the C terminus of the DBD.

Co-binding Partners
Name	Interaction	Effect	Reference
DAX1	Physical, Functional	Inhibition of LRH-1 dependent transactivation.	21
SHP	Physical, Functional	Inhibition of LRH-1 dependent transactivation.	14,21
Beta catenin	Physical, Functional	DNA binding and LRH-1 interacts with the armadillo repeats of beta-catenin. Beta catenin:LRH-1 complex formation enhance LRH-1 dependent transcriptional activation of the Cyclin E1 gene and beta catenin dependent activation of the Cyclin D1 gene.	2

Main Co-regulators
Name	Activity	Specific	Ligand dependent	AF-2 dependent	Comments	References
NCOA1	Co-activator	No	No	Yes		28
NCOA3	Co-activator	No	No	Yes		17
EP300	Co-activator	No	No	Yes		27
EID1	Co-activator	No	No	No	MBF-1 interacts with the Ftz-F1 box of LRH-1 and not with the AF-2. MBF-1 does not possess any of the classical histone modifying activities such as histone acetyl- or methyl transferase activities, linked to chromatin remodeling, but interacts in vitro with the transcription factor IID complex	3
PROX1	Co-repressor	No	No	No	Prox1 interacts with both the ligand binding domain (LBD) and the DNA binding domain (DBD) of hLRH-1. Gel shift assays reveal that Prox1 impairs the binding of hLRH-1 to the promoter of human cyp7a1 gene	20,25
SNW1	Co-activator	No	No	No	NCOA62 interacts and selectively activates LRH-1 in cell transfections assays. The SNW domain is required. (personal expert communication)

Main Target Genes
Name	Species	Effect	Technique	Comments	References
ABCG5	Human	Activated	Transient transfection, EMSA, Other	LRH-1 activates the ABCG5/ABCG8 intergenic promoter	7
CYP11A1	Human	Activated	Transient transfection, EMSA		11
APOA1	Human	Activated	ChIP, Transient transfection, EMSA, Other	Activation of Apolipoprotein A-1 was shown in all species examined	5
Ccne1	Mouse	Activated			2
STAR	Human	Activated	Transient transfection, EMSA	shown in all species	12
ABCG8	Human	Activated	Transient transfection, EMSA, Other	LRH-1 activates the ABCG5/ABCG8 intergenic promoter	7

Tissue Distribution

adult mammal tissues (endodermal; liver, pancreas, intestine) and species-specific in (pre-adipocyte ovarial, placenta, adrenal and testis)

Species:	Human
Technique:	Northern, In situ, Western, Immunohistology
References:	1,4,6,8,10,13,15,22,24,26

Physiological Consequences of Altering Gene Expression

LRH-1 Knock-out Mice: LRH-1 -/- embryos die at E6.5–7.5, with features typical of visceral endoderm dysfunction. LRH-1 +/- adult mice are hypocholesterolemic, and express liver FTF at about 40% of the normal level. Haplo insufficiency of LRH-1 blunts intestinal tumorigenesis in the ApcMin/+ mice, a genetic model of intestinal cancer. Lrh-1+/- mice are protected against the formation of aberrant crypt foci in the colon of mice exposed to the carcinogen azoxymethane.

Species:	Mouse
Tissue:
Technique:	Knockout
References:	2,19,23

Phenotypes, Alleles and Disease Models

Mouse data from MGI

Click here to show/hide data

Allele	Composition & genetic background	Accession	Phenotype Id	Phenotype	Reference
Nr5a2^tm1Bel	Nr5a2^tm1Bel/Nr5a2^tm1Bel involves: 129/Sv * C57BL/6 * SJL	MGI:1346834	MP:0005029	abnormal amnion morphology	PMID: 15014077
Nr5a2^tm1Lex	Nr5a2^tm1Lex/Nr5a2^tm1Lex involves: 129	MGI:1346834	MP:0005029	abnormal amnion morphology	PMID: 15831456
Nr5a2^tm1Sakl\|Tg(Alb-cre)21Mgn	Nr5a2^tm1Sakl/Nr5a2^tm1Sakl,Tg(Alb-cre)21Mgn/0 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA	MGI:1346834 MGI:2176226	MP:0004773	abnormal bile composition	PMID: 18323469
Nr5a2⁺\|Nr5a2^tm1Bel	Nr5a2^tm1Bel/Nr5a2⁺ involves: 129/Sv * C57BL/6 * SJL	MGI:1346834	MP:0004774	abnormal bile salt level	PMID: 14766742
Alb⁺\|Alb^{tm1(cre/ERT2)Mtz}\|Nr5a2^tm2Sjns	Alb^{tm1(cre/ERT2)Mtz}/Alb⁺,Nr5a2^tm2Sjns/Nr5a2^tm2Sjns involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL	MGI:1346834 MGI:87991	MP:0004774	abnormal bile salt level	PMID: 17908794
Nr5a2⁺\|Nr5a2^tm1Auw	Nr5a2^tm1Auw/Nr5a2⁺ involves: 129P2/OlaHsd	MGI:1346834	MP:0000495	abnormal colon morphology	PMID: 17670946
Nr5a2⁺\|Nr5a2^tm1Auw	Nr5a2^tm1Auw/Nr5a2⁺ involves: 129P2/OlaHsd * C57BL/6J	MGI:1346834	MP:0000490	abnormal crypts of Lieberkuhn morphology	PMID: 15327767
Nr5a2⁺\|Nr5a2^tm1Auw	Nr5a2^tm1Auw/Nr5a2⁺ involves: 129P2/OlaHsd	MGI:1346834	MP:0000490	abnormal crypts of Lieberkuhn morphology	PMID: 17670946
Nr5a2^tm1Bel	Nr5a2^tm1Bel/Nr5a2^tm1Bel involves: 129/Sv * C57BL/6 * SJL	MGI:1346834	MP:0001675	abnormal ectoderm development	PMID: 15014077
Nr5a2^tm1Lex	Nr5a2^tm1Lex/Nr5a2^tm1Lex involves: 129	MGI:1346834	MP:0001675	abnormal ectoderm development	PMID: 15831456
Nr5a2^tm1Lex	Nr5a2^tm1Lex/Nr5a2^tm1Lex involves: 129	MGI:1346834	MP:0001672	abnormal embryogenesis/ development	PMID: 15831456
Nr5a2^tm1Lex	Nr5a2^tm1Lex/Nr5a2^tm1Lex involves: 129	MGI:1346834	MP:0001685	abnormal endoderm development	PMID: 15831456
Alb⁺\|Alb^{tm1(cre/ERT2)Mtz}\|Nr5a2^tm2Sjns	Alb^{tm1(cre/ERT2)Mtz}/Alb⁺,Nr5a2^tm2Sjns/Nr5a2^tm2Sjns involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL	MGI:1346834 MGI:87991	MP:0003868	abnormal feces composition	PMID: 17908794
Alb⁺\|Alb^{tm1(cre/ERT2)Mtz}\|Nr5a2^tm2Sjns	Alb^{tm1(cre/ERT2)Mtz}/Alb⁺,Nr5a2^tm2Sjns/Nr5a2^tm2Sjns involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL	MGI:1346834 MGI:87991	MP:0005342	abnormal lipid absorption	PMID: 17908794
Nr5a2^tm1Bel	Nr5a2^tm1Bel/Nr5a2^tm1Bel involves: 129/Sv * C57BL/6 * SJL	MGI:1346834	MP:0001680	abnormal mesoderm development	PMID: 15014077
Nr5a2⁺\|Nr5a2^tm1Bel	Nr5a2^tm1Bel/Nr5a2⁺ involves: 129/Sv * C57BL/6 * SJL	MGI:1346834	MP:0009661	abnormal pregnancy	PMID: 17409375
Nr5a2^tm1Bel	Nr5a2^tm1Bel/Nr5a2^tm1Bel involves: 129/Sv * C57BL/6 * SJL	MGI:1346834	MP:0001674	abnormal triploblastic development	PMID: 15014077
Nr5a2⁺\|Nr5a2^tm1Auw	Nr5a2^tm1Auw/Nr5a2⁺ involves: 129P2/OlaHsd	MGI:1346834	MP:0001652	colonic necrosis	PMID: 17670946
Nr5a2^tm1Sjns\|Tg(Vil-cre/ERT2)23Syr	Nr5a2^tm1Sjns/Nr5a2^tm1Sjns,Tg(Vil-cre/ERT2)23Syr/? involves: 129/Sv * C57BL/6 * DBA/2 * SJL	MGI:1346834 MGI:3053810	MP:0001652	colonic necrosis	PMID: 17670946
Nr5a2^tm1Sakl\|Tg(Alb-cre)21Mgn	Nr5a2^tm1Sakl/Nr5a2^tm1Sakl,Tg(Alb-cre)21Mgn/0 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA	MGI:1346834 MGI:2176226	MP:0005632	decreased circulating aspartate transaminase level	PMID: 18323469
Nr5a2^tm1Sakl\|Tg(Vil-cre)997Gum	Nr5a2^tm1Sakl/Nr5a2^tm1Sakl,Tg(Vil-cre)997Gum/0 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL	MGI:1346834 MGI:2446957	MP:0005632	decreased circulating aspartate transaminase level	PMID: 18323469
Nr5a2⁺\|Nr5a2^tm1Bel	Nr5a2^tm1Bel/Nr5a2⁺ involves: 129/Sv * C57BL/6 * SJL	MGI:1346834	MP:0005179	decreased circulating cholesterol level	PMID: 15014077
Nr5a2^tm1Sakl\|Tg(Alb-cre)21Mgn	Nr5a2^tm1Sakl/Nr5a2^tm1Sakl,Tg(Alb-cre)21Mgn/0 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA	MGI:1346834 MGI:2176226	MP:0005179	decreased circulating cholesterol level	PMID: 18323469
Nr5a2^tm1Sakl\|Tg(Vil-cre)997Gum	Nr5a2^tm1Sakl/Nr5a2^tm1Sakl,Tg(Vil-cre)997Gum/0 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL	MGI:1346834 MGI:2446957	MP:0005179	decreased circulating cholesterol level	PMID: 18323469
Nr5a2⁺\|Nr5a2^tm1Bel	Nr5a2^tm1Bel/Nr5a2⁺ involves: 129/Sv * C57BL/6 * SJL	MGI:1346834	MP:0005185	decreased circulating progesterone level	PMID: 17409375
Nr5a2⁺\|Nr5a2^tm1Auw	Nr5a2^tm1Auw/Nr5a2⁺ involves: C57BL/6J	MGI:1346834	MP:0002780	decreased circulating testosterone level	PMID: 17289919
Nr5a2^tm1Lex	Nr5a2^tm1Lex/Nr5a2^tm1Lex involves: 129	MGI:1346834	MP:0001698	decreased embryo size	PMID: 15831456
Nr5a2⁺\|Nr5a2^tm1Auw	Nr5a2^tm1Auw/Nr5a2⁺ involves: C57BL/6J	MGI:1346834	MP:0004929	decreased epididymis weight	PMID: 17289919
Nr5a2⁺\|Nr5a2^tm1Auw	Nr5a2^tm1Auw/Nr5a2⁺ involves: C57BL/6J	MGI:1346834	MP:0004910	decreased seminal vesicle weight	PMID: 17289919
Nr5a2⁺\|Nr5a2^tm1Auw	Nr5a2^tm1Auw/Nr5a2⁺ involves: 129P2/OlaHsd	MGI:1346834	MP:0001785	edema	PMID: 17670946
Nr5a2^tm1Bel	Nr5a2^tm1Bel/Nr5a2^tm1Bel involves: 129/Sv * C57BL/6 * SJL	MGI:1346834	MP:0006205	embryonic lethality before somite formation	PMID: 15014077
Nr5a2^tm1Lex	Nr5a2^tm1Lex/Nr5a2^tm1Lex involves: 129	MGI:1346834	MP:0006207	embryonic lethality during organogenesis	PMID: 15831456
Alb⁺\|Alb^{tm1(cre/ERT2)Mtz}\|Nr5a2^tm2Sjns	Alb^{tm1(cre/ERT2)Mtz}/Alb⁺,Nr5a2^tm2Sjns/Nr5a2^tm2Sjns involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL	MGI:1346834 MGI:87991	MP:0004789	increased bile salt level	PMID: 17908794
Nr5a2⁺\|Nr5a2^tm1Auw	Nr5a2^tm1Auw/Nr5a2⁺ involves: 129P2/OlaHsd	MGI:1346834	MP:0008537	increased susceptibility to induced colitis	PMID: 17670946
Nr5a2^tm1Sjns\|Tg(Vil-cre/ERT2)23Syr	Nr5a2^tm1Sjns/Nr5a2^tm1Sjns,Tg(Vil-cre/ERT2)23Syr/? involves: 129/Sv * C57BL/6 * DBA/2 * SJL	MGI:1346834 MGI:3053810	MP:0008537	increased susceptibility to induced colitis	PMID: 17670946
Nr5a2⁺\|Nr5a2^tm1Bel	Nr5a2^tm1Bel/Nr5a2⁺ involves: 129/Sv * C57BL/6 * SJL	MGI:1346834	MP:0004904	increased uterus weight	PMID: 17409375
Nr5a2^tm1Auw	Nr5a2^tm1Auw/Nr5a2^tm1Auw involves: 129P2/OlaHsd * C57BL/6J	MGI:1346834	MP:0002080	prenatal lethality	PMID: 15327767
Nr5a2⁺\|Nr5a2^tm1Lex	Nr5a2^tm1Lex/Nr5a2⁺ involves: 129	MGI:1346834	MP:0002080	prenatal lethality	PMID: 15831456
Nr5a2⁺\|Nr5a2^tm1Bel	Nr5a2^tm1Bel/Nr5a2⁺ involves: 129/Sv * C57BL/6 * SJL	MGI:1346834	MP:0001923	reduced female fertility	PMID: 17409375

Biologically Significant Variants

LRH-1v1: identical to the most abundant isoform of LRH-1 with a larger A/B domain

Protein accession:	NP_995582
Amino acids:	541
Type:	Splice variant
Species:	Human
References:	8,16

LRH-1v2: smallest isoform, contains deletion within the D and E domains, caused by another alternative splicing event in exon 5, and cannot activate transcription although the transcription factors involved have not yet been identified.

Protein accession:	NP_003813
Amino acids:	495
Type:	Splice variant
Species:	Human
References:	16,29

REFERENCES

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1. Boerboom, D; Pilon, N; Behdjani, R; Silversides, DW; Sirois, J. (2000) Expression and regulation of transcripts encoding two members of the NR5A nuclear receptor subfamily of orphan nuclear receptors, steroidogenic factor-1 and NR5A2, in equine ovarian cells during the ovulatory process. Endocrinology, 141 (12): 4647-56. [PMID:11108279]

2. Botrugno, OA; Fayard, E; Annicotte, JS; Haby, C; Brennan, T; Wendling, O; Tanaka, T; Kodama, T; Thomas, W; Auwerx, J; Schoonjans, K. (2004) Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation. Mol. Cell, 15 (4): 499-509. [PMID:15327767]

3. Brendel, C; Gelman, L; Auwerx, J. (2002) Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism. Mol. Endocrinol., 16 (6): 1367-77. [PMID:12040021]

4. Clyne, CD; Speed, CJ; Zhou, J; Simpson, ER. (2002) Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes. J. Biol. Chem., 277 (23): 20591-7. [PMID:11927588]

5. Delerive, P; Galardi, CM; Bisi, JE; Nicodeme, E; Goodwin, B. (2004) Identification of liver receptor homolog-1 as a novel regulator of apolipoprotein AI gene transcription. Mol. Endocrinol., 18 (10): 2378-87. [PMID:15218078]

6. Fahmi, AI; Patel, M; Stevens, EB; Fowden, AL; John, JE; Lee, K; Pinnock, R; Morgan, K; Jackson, AP; Vandenberg, JI. (2001) The sodium channel beta-subunit SCN3b modulates the kinetics of SCN5a and is expressed heterogeneously in sheep heart. J. Physiol. (Lond.), 537 (Pt 3): 693-700. [PMID:11744748]

7. Freeman, LA; Kennedy, A; Wu, J; Bark, S; Remaley, AT; Santamarina-Fojo, S; Brewer, HB. (2004) The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter. J. Lipid Res., 45 (7): 1197-206. [PMID:15121760]

8. Galarneau, L; Drouin, R; Bélanger, L. (1998) Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization. Cytogenet. Cell Genet., 82 (3-4): 269-70. [PMID:9858833]

9. Galarneau, L; Paré, JF; Allard, D; Hamel, D; Levesque, L; Tugwood, JD; Green, S; Bélanger, L. (1996) The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family. Mol. Cell. Biol., 16 (7): 3853-65. [PMID:8668203]

10. Hinshelwood, MM; Repa, JJ; Shelton, JM; Richardson, JA; Mangelsdorf, DJ; Mendelson, CR. (2003) Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function. Mol. Cell. Endocrinol., 207 (1-2): 39-45. [PMID:12972182]

11. Kim, JW; Havelock, JC; Carr, BR; Attia, GR. (2005) The orphan nuclear receptor, liver receptor homolog-1, regulates cholesterol side-chain cleavage cytochrome p450 enzyme in human granulosa cells. J. Clin. Endocrinol. Metab., 90 (3): 1678-85. [PMID:15613430]

12. Kim, JW; Peng, N; Rainey, WE; Carr, BR; Attia, GR. (2004) Liver receptor homolog-1 regulates the expression of steroidogenic acute regulatory protein in human granulosa cells. J. Clin. Endocrinol. Metab., 89 (6): 3042-7. [PMID:15181096]

13. Li, M; Xie, YH; Kong, YY; Wu, X; Zhu, L; Wang, Y. (1998) Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus. J. Biol. Chem., 273 (44): 29022-31. [PMID:9786908]

14. Li, Y; Choi, M; Suino, K; Kovach, A; Daugherty, J; Kliewer, SA; Xu, HE. (2005) Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner. Proc. Natl. Acad. Sci. U.S.A., 102 (27): 9505-10. [PMID:15976031]

15. Liu, DL; Liu, WZ; Li, QL; Wang, HM; Qian, D; Treuter, E; Zhu, C. (2003) Expression and functional analysis of liver receptor homologue 1 as a potential steroidogenic factor in rat ovary. Biol. Reprod., 69 (2): 508-17. [PMID:12672674]

16. Nitta, M; Ku, S; Brown, C; Okamoto, AY; Shan, B. (1999) CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene. Proc. Natl. Acad. Sci. U.S.A., 96 (12): 6660-5. [PMID:10359768]

17. Ortlund, EA; Lee, Y; Solomon, IH; Hager, JM; Safi, R; Choi, Y; Guan, Z; Tripathy, A; Raetz, CR; McDonnell, DP; Moore, DD; Redinbo, MR. (2005) Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nat. Struct. Mol. Biol., 12 (4): 357-63. [PMID:15723037]

18. Pare, JF; Roy, S; Galarneau, L; Belanger, L. (2001) The mouse fetoprotein transcription factor (FTF) gene promoter is regulated by three GATA elements with tandem E box and Nkx motifs, and FTF in turn activates the Hnf3beta, Hnf4alpha, and Hnf1alpha gene promoters. J. Biol. Chem., 276 (16): 13136-44. [PMID:11145965]

19. Paré, JF; Malenfant, D; Courtemanche, C; Jacob-Wagner, M; Roy, S; Allard, D; Bélanger, L. (2004) The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element. J. Biol. Chem., 279 (20): 21206-16. [PMID:15014077]

20. Qin, J; Gao, DM; Jiang, QF; Zhou, Q; Kong, YY; Wang, Y; Xie, YH. (2004) Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene. Mol. Endocrinol., 18 (10): 2424-39. [PMID:15205472]

21. Sablin, EP; Krylova, IN; Fletterick, RJ; Ingraham, HA. (2003) Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1. Mol. Cell, 11 (6): 1575-85. [PMID:12820970]

22. Schoonjans, K; Annicotte, JS; Huby, T; Botrugno, OA; Fayard, E; Ueda, Y; Chapman, J; Auwerx, J. (2002) Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I. EMBO Rep., 3 (12): 1181-7. [PMID:12446566]

23. Schoonjans, K; Dubuquoy, L; Mebis, J; Fayard, E; Wendling, O; Haby, C; Geboes, K; Auwerx, J. (2005) Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation. Proc. Natl. Acad. Sci. U.S.A., 102 (6): 2058-62. [PMID:15684064]

24. Sirianni, R; Seely, JB; Attia, G; Stocco, DM; Carr, BR; Pezzi, V; Rainey, WE. (2002) Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes. J. Endocrinol., 174 (3): R13-7. [PMID:12208674]

25. Steffensen, KR; Holter, E; Båvner, A; Nilsson, M; Pelto-Huikko, M; Tomarev, S; Treuter, E. (2004) Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue. EMBO Rep., 5 (6): 613-9. [PMID:15143342]

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27. Weck, J; Mayo, KE. (2006) Switching of NR5A proteins associated with the inhibin alpha-subunit gene promoter after activation of the gene in granulosa cells. Mol. Endocrinol., 20 (5): 1090-103. [PMID:16423880]

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To cite this database page, please use the following:

5A. Fushi tarazu F1-like receptors: Liver receptor homolog-1. Last modified on 01/03/2012. Accessed on 19/06/2013. IUPHAR database (IUPHAR-DB), http://iuphar-db.org/DATABASE/ObjectDisplayForward?00objectId=633.