Ligand Id: 294
Ligand name acetylcholine

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 26.3
Molecular weight 146.12
XLogP -0.1
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands
Natural/Endogenous Targets
Target DB page
M1 receptor View in IUPHAR-DB
View in GRAC
M2 receptor View in IUPHAR-DB
View in GRAC
M3 receptor View in IUPHAR-DB
View in GRAC
M4 receptor View in IUPHAR-DB
View in GRAC
M5 receptor View in IUPHAR-DB
View in GRAC
Transporters
Transporter DB page EC number Reaction Reference
Vesicular acetylcholine transporter View in GRAC 1-2

Selectivity data from IUPHAR-DB

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
M5 receptor Agonist Full agonist 6.1 pKi - 4
M2 receptor Agonist Full agonist 4.3 – 6.5 pKi - 3-6
M4 receptor Agonist Full agonist 4.5 – 5.6 pKi - 3-5
M3 receptor Agonist Full agonist 4.5 – 5.4 pKi - 3-5
M1 receptor Agonist Full agonist 4.3 – 4.9 pKi - 3,5
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
M2 receptor Agonist Full agonist 6.4 pKi - 6
M3 receptor Agonist Full agonist 5.6 pKi - 4
M1 receptor Agonist Full agonist 5.0 pKi - 4

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
For more details please contact: curators@iuphar-db.org

Contact us | Print | Back to top | Help