Ligand Id: 2330
Ligand name clotrimazole

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 17.82
Molecular weight 344.11
XLogP 8.56
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands

Selectivity data from IUPHAR-DB

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPM2 Pore Blocker Antagonist - - 3x10-6 - 3x10-5 5
TRPM4 Gating inhibitor Antagonist - - 1x10-6 - 1x10-5 6
KCa3.1 Pore Blocker Inhibition 6.41 – 7.62 (median: 7.16) pKd - 1-4
Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Pregnane X receptor Agonist Agonist - - - 8
Constitutive androstane receptor Antagonist Antagonist 6.16 pIC50 - 7

Selectivity data from the Guide to Receptors and Channels (GRAC), 5th Edition.

Selectivity at human targets (unless otherwise stated)
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
TRPM2 Channel blocker - - - -
TRPM4 Channel blocker - - - -
TRPM8 Channel blocker - - - -

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
For more details please contact: curators@iuphar-db.org

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