Targets:

• Receptors »
  • Latest Pairings
  • 7TM Receptor List
  • NHR List
• Ion Channels »
  • VGIC List
  • LGIC List
• Enzymes »

• Ligand List
• Contributor List
• Help Page
• Citing the Database
• Linking to us
• Hot Topics 
• Subscribe

• Nomenclature Guidelines
• Terms and Symbols
• Publications
• About NC-IUPHAR
• About IUPHAR
• Useful links
• Privacy and Cookie Policy
• NC-IUPHAR newsletter

Visit our sister site

Funded by:

Sponsors:

We thank past major sponsors UNESCO and Incyte

2D Structure

Calculated Physico-chemical Properties Hydrogen bond acceptors 5 Hydrogen bond donors 3 Rotatable bonds 12 Topological polar surface area 94.83 Molecular weight 352.22 XLogP 2.9 No. Lipinski's rules broken 1 Molecular properties generated using the CDK

Natural/Endogenous Targets Target DB page DP1 receptor View in IUPHAR-DB View in GRAC DP2 receptor View in IUPHAR-DB View in GRAC EP1 receptor View in IUPHAR-DB View in GRAC EP2 receptor View in IUPHAR-DB View in GRAC EP3 receptor View in IUPHAR-DB View in GRAC EP4 receptor View in IUPHAR-DB View in GRAC FP receptor View in IUPHAR-DB View in GRAC IP1 receptor View in IUPHAR-DB View in GRAC TP receptor View in IUPHAR-DB View in GRAC Selectivity data from IUPHAR-DB Selectivity at human GPCRs Key to terms and symbols Click column headers to sort Target Type Action Affinity Units Concentration range (M) Reference EP4 receptor Agonist Full agonist 8.7 – 9.0 pKi - 13-14 DP1 receptor Agonist Full agonist 7.8 – 9.2 pKi - 1-3,5 DP2 receptor Agonist Full agonist 7.6 – 8.6 pKi - 8-9 FP receptor Agonist Full agonist 7.7 pKi - 15 EP2 receptor Agonist Full agonist 5.0 pKi - 13 EP1 receptor Agonist Full agonist 4.7 pKi - 12 EP4 receptor Agonist Full agonist 8.77 pEC50 - 16 Selectivity at mouse GPCRs Key to terms and symbols Click column headers to sort Target Type Action Affinity Units Concentration range (M) Reference DP1 receptor Agonist Full agonist 7.7 pKi - 4 DP2 receptor Agonist Full agonist 7.4 – 7.5 pKi - 7,10 FP receptor Agonist Full agonist 7.3 pKi - 4 EP3 receptor Agonist Full agonist 6.55 pKi - 4 Selectivity at rat GPCRs Key to terms and symbols Click column headers to sort Target Type Action Affinity Units Concentration range (M) Reference DP1 receptor Agonist Full agonist 7.6 pKi - 1 EP3 receptor (EP3α isoform) Agonist Full agonist 5.9 – 8.89 pKi - 11 EP4 receptor Agonist Full agonist 5.9 pKi - 11 EP2 receptor Agonist Full agonist 5.3 pKi - 11 EP1 receptor Agonist Full agonist 5.2 pKi - 11 EP3 receptor (EP3α isoform) Agonist Full agonist 7.89 pEC50 - 11 DP2 receptor Agonist Full agonist 8.2 pIC50 - 6 Selectivity data from the Guide to Receptors and Channels (GRAC), 5th Edition. Rank order of potency at human receptors (unless otherwise stated) Description Rank order of potency Reference Rank order of potency at EP1 receptor PGE2 > PGF2α, PGI2 > PGD2, thromboxane A2 Rank order of potency at DP2 receptor PGD2 >> PGF2α, PGE2 > PGI2, thromboxane A2 Rank order of potency at DP1 receptor PGD2 >> PGE2 > PGF2α > PGI2, thromboxane A2 Rank order of potency at TP receptor thromboxane A2 = PGH2 >> PGD2, PGE2, PGF2α, PGI2 Rank order of potency at IP1 receptor PGI2 >> PGD2, PGE2, PGF2α > thromboxane A2 Rank order of potency at FP receptor PGF2α > PGD2 > PGE2 > PGI2, thromboxane A2 Rank order of potency at EP4 receptor PGE2 > PGF2α, PGI2 > PGD2, thromboxane A2 Rank order of potency at EP3 receptor PGE2 > PGF2α, PGI2 > PGD2, thromboxane A2 Rank order of potency at EP2 receptor PGE2 > PGF2α, PGI2 > PGD2, thromboxane A2 Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data. For more details please contact: curators@iuphar-db.org

Contact us | Print | Back to top | Help